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The prescribing of nonsteroidal anti-inflammatory drugs in the elderly

Published online by Cambridge University Press:  17 November 2008

R Goorah
Affiliation:
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
H Wynne*
Affiliation:
University of Newcastle upon Tyne, Newcastle upon Tyne, UK
*
H Wynne, King Edward Ward Offices, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NEl 4LP, UK.

Abstract

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Type
Occasional paper
Copyright
Copyright © Cambridge University Press 1995

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References

1Committee on Safety of Medicines. Update – nonsteroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions. BMJ 1986; 292: 614.Google Scholar
2Baum, C, Kennedy, DL, Forbes, MB. Utilisation of nonsteroidal anti-inflammatory drugs. Arthritis Rheum 1985; 28: 686–92.CrossRefGoogle Scholar
3Walt, R, Katschinski, B, Logan, R, Ashley, J, Langman, M. Rising frequency of ulcer perforations in elderly people in the United Kingdom. Lancet 1986; 8: 489–92.Google Scholar
4Collier, D St J, Pain, JA. Nonsteroidal antiinflammatory drugs and peptic ulcer perforations. Gui 1985; 26: 359–63.Google Scholar
5Sommerville, K, Faulkner, G, Langman, MJS. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986; i: 462–64.CrossRefGoogle Scholar
6Fries, JF, Williams, CA, Bloch, DA, Michel, BA. Nonsteroidal anti-inflammatory drug associated gastropathy: incidence and risk factor models. Am J Med 1991; 91: 213–22.CrossRefGoogle ScholarPubMed
7Griffin, MR, Piper, JM, Daugherty, JR, Snowden, M, Ray, WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257–63.CrossRefGoogle ScholarPubMed
8Castleden, CM, Pickles, H. Suspected adverse drug reactions in elderly patients reported to the Committee on Safety of Medicines. Br J Clin PHarmacol 1988; 26: 347–51.CrossRefGoogle Scholar
9Lawrence, JS, Bremner, JM, Bier, F. Osteoarthritis: prevalence in the population and relationship between symptoms and X-ray changes. Ann Rheum Res 1966; 25: 124.CrossRefGoogle ScholarPubMed
10Felson, DT, Naimark, A, Anderson, J, Kazis, L, Castelli, W, Meenan, RF. The prevalence of knee osteoarthritis in the elderly. Arthritis Rheum 1987; 30: 914–18.CrossRefGoogle ScholarPubMed
11Felson, DT, Anderson, JJ, Naimark, A, Kannel, W, Meenan, RF. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis. J Rheumatol 1990; 16: 1241–45.Google Scholar
12Dieppe, PA, Frankel, SJ, Toth, B. Is research into the treatment of osteoarthritis with nonsteroidal anti-inflammatory drugs misdirected? Lancet 1993; 341: 353–54.CrossRefGoogle ScholarPubMed
13Amadio, P, Cummings, DM. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Clin Ther Res 1983; 34: 5966.Google Scholar
14Bradley, JD, Brandt, KD, Katz, BP, Kalisinski, LA, Ryan, SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991; 325: 8791.CrossRefGoogle ScholarPubMed
15Parr, G, Darekar, B, Fletcher, A, Bulpitt, CJ. Joint pain and quality fo life: results of a randomised trial. Br J Clin Pharmacol 1989; 27: 235–42.CrossRefGoogle Scholar
16March, L, Irwig, L, Schwarz, J, Simpson, J, Chock, C, Brooks, P. n of 1 trials comparing a nonsteroidal antiinflammatory drug with paracetamol in osteoarthritis. BMJ 1994; 309: 1041–46.CrossRefGoogle ScholarPubMed
17Day, RO, Graham, GG, Williams, KM, Brookes, PM. Variability in response to NSAIDs. Fact or Fiction. Drugs 1988; 36: 643–51.Google Scholar
18Bloom, BS. Cost of treating arthritis and NSAID-related gastrointestinal side effects. Aliment Pharmacol Ther 1988; 2S: 131–39.Google Scholar
19Langman, MJS, Weil, J, Wainwright, P et al. Risks of bleeding peptic ulcer associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343: 1075–78.CrossRefGoogle Scholar
20Garcia-Rodriguez, LA, Jick, K. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343: 769–72.CrossRefGoogle Scholar
21Morgan, GJ, Poland, M, De Lapp, RE. Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen and piroxicam in the elderly. Am J Med 1993; 95 (suppl 2A): 195265.CrossRefGoogle ScholarPubMed
22Roth, SH, Tindall, EA, Jain, AK et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med 1993; 153: 2565–71.Google Scholar
23Laporte, JR, Carne, X, Vidal, X. Upper gastrointestinal bleeding in relation to previous use of analgesics and NSAIDs. Lancet 1991; 337: 8589.Google Scholar
24Patrono, C, Dunn, MJ. The clinical significance of inhibition of renal prostaglandin synthesis. Kidney Int 1987; 32: 112.CrossRefGoogle ScholarPubMed
25Stillman, MT, Schlesinger, PA. Nonsteroidal anti-inflammatory drug nephrotoxicity: should we be concerned? Arch Intern Med 1990; 150: 268–70.Google Scholar
26McCallion, J, McLaren, B, Belch, JJF, Erwin, L. Effects of fenbufen and indomethacin on renal function and prostaglandin synthesis in elderly patients. J Clin Exp Gerontol 1989; 11: 97105.Google Scholar
27Wilkieson, CA, Erwin, L, Belch, JJF. Effects of nabumetone and indomethacin on renal function and serum prostaglandin synthesis. J Clin Exp Gerontol 1992; 14: 5763.Google Scholar
28Ritter, MA, Gioe, TJ. The effect of indomethacin on para-articular ectopie ossification following total hip arthroplasty. Clin Orthop 1982; 167: 113–17.Google Scholar
29Rashad, S, Revell, P, Hemingway, A et al. Effects of NSAIDs on the course of osteoarthritis. Lancet 1989; ii: 519–22.CrossRefGoogle Scholar
30Palmoski, MJ, Brandt, KD. Effects of some nonsteroidal anti-inflammatory drugs on prosteoglycan metabolism and organisation in canine articular cartilage. Arthritis Rheum 1983; 23: 1010–20.CrossRefGoogle Scholar
31Wynne, HA, Rawlins, MD. Are systemic levels of NSAIDs relevant to acute upper gastrointestinal haemorrhage? Eur J Clin Pharmacol 1993; 44: 309–13.CrossRefGoogle ScholarPubMed
32Hazes, JMW, Wilman, AJ. Review of UK data on the rheumatic diseases – 2. Rheumatoid arthritis. Br J Rheumatol 1990; 29: 310–12.CrossRefGoogle Scholar
33Capell, HA, Rennie, JAN, Rooney, PJ et al. Patient compliance: a novel method of testing NSAID in RA. J Rheumatol 1979; 6: 584–92.Google Scholar
34Woodhouse, KW, Wynne, H. The pharmacokinetics of nonsteroidal anti-inflammatory drugs in the elderly. Clin Pharmacokinet 1987; 12: 111–22.CrossRefGoogle ScholarPubMed
35Graham, D, Jaszewski, R, Stromatt, S, Brown, J. Treatment of NSAID induced gastric ulcer with misoprostol. Gastroenterology 1990; 98: A52.Google Scholar
36Ballinger, AB, Kumar, PJ, Scott, DL. Misoprostol in the prevention of gastroduodenal damage in rheumatology. Ann Rheum Dis 1992; 51: 1089–93.CrossRefGoogle ScholarPubMed
37Agrawal, NM, Dajani, EZ. Prevention and treatment of ulcers induced by nonsteroidal anti-inflammatory drugs. J Assoc Acad Minor Phys 1992; 3: 142–48.Google ScholarPubMed
38Hawkey, CJ. Nonsteroidal anti-inflammatory drugs and peptic ulcers. BMJ 1990; 300: 278–84.Google Scholar
39Roth, SH, Bennett, RE, Mitchell, CS, Hartman, RJ. Cimetidine therapy in NSAID gastropathy-double blind long term evaluation. Arch Intern Med 1987; 147: 1798–810.Google Scholar
40Graham, DY, Agrawal, N, Roth, SH. Prevention of NSAID-induced gastric ulcer with synthetic prostaglandin, misoprostol – a multicentre double blind, placebo controlled trial. Lancet 1988; ii: 1277–281.CrossRefGoogle Scholar
41Pullar, T, Capell, HA, Millar, A, Brooks, RG. Alternative Medicine: cost and subjective benefit in rheumatoid arthritis. BMJ 1982; 285: 1629–31.Google Scholar
42Mazzuca, SA. Does patient education in chronic disease have therapeutic value? J Chronic Dis 1982; 35: 521–29.CrossRefGoogle ScholarPubMed
43Wynne, H, Campbell, M. Pharmacoeconomics of NSAIDs. Pharmacoeconomics 1993; 31: 107–23.CrossRefGoogle Scholar
44Andersson, S, Fredin, H, Lindbery, H, Sanzen, L, Westlin, N. Ibuprofen and compression bandage treatment of ankle sprains. Acta Orthop Scand 1983; 54: 322–25.CrossRefGoogle ScholarPubMed
45Diebschlag, W, Nocker, W, Bullingham, R. A double-blind study of the efficacy of topical ketorolac tromathamine gel in the treatment of ankle sprain in comparison to placebo and etofenamate. J Clin Pharmacol 1990; 30: 8289.CrossRefGoogle ScholarPubMed
46Akermark, C, Forsskahl, B. Topical indomethacin in overuse injuries in athletes. Int J Sports Med 1990; 11: 393–96.Google ScholarPubMed
47Goodwin, JS, Regan, M. Cognitive dysfunction associated with naproxen and ibuprofen in the elderly. Arthritis Rheum 1982; 25: 1013–14.CrossRefGoogle ScholarPubMed