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Human lifespan: what determines the intrinsic length of human lives?

Published online by Cambridge University Press:  01 March 2011

David JM Crosse
David JM Crosse*
Affiliation:
Stirling Royal Infirmary, Scotland, UK
*
Address for correspondence: Dr David Crosse, NHS Forth Valley, Stirling Road, Larbert FK5 4WR, Scotland. Email: [email protected]
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Summary

Humans have an intrinsic lifespan of approximately 120 years. Classic evolutionary theories of ageing explain the limit as a response to inevitable cellular damage. The theories share the notion that natural selection acts less strongly to purge deleterious genes that are expressed after reproduction. Reproduction schedules are influenced by a species' ecology and so it is ecological factors which explain interspecies variation in lifespan. Human ecology has favoured the selection of an unusually large brain that both confers advantages that promote longevity and requires longevity to make it a worthwhile investment. The relatively long human lifespan therefore co-evolved with the large human brain.

Keywords

lifespanageingevolution
Type
Biological gerontology
Information
Reviews in Clinical Gerontology , Volume 21 , Issue 3 , August 2011 , pp. 193 - 200
Copyright
Copyright © Cambridge University Press 2011

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References

1Abrams, PA. Mortality and lifespan. Nature 2004; 431: 1048–49.CrossRefGoogle ScholarPubMed
2de Magalhães, JP, Budovsky, A, Lehmann, G, Costa, J, Li, Y, Fraifeld, V, Church, GM. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell 2009; 8: 65–72.CrossRefGoogle ScholarPubMed
3Vijg, J, Campisi, J. Puzzles, promises and a cure for ageing. Nature 2008; 454: 1065–71.Google Scholar
4Partridge, L, Gems, D. Mechanisms of ageing: public or private? Nat Rev Genet 2002; 3: 165–75.CrossRefGoogle ScholarPubMed
5Beckman, KB, Ames, BN. The free radical theory of aging matures. Physiol Rev 1998; 78: 547–81.CrossRefGoogle ScholarPubMed
6Partridge, L. The new biology of ageing. Phil Trans R Soc Lond B Biol Sci 2010; 365: 147–54.CrossRefGoogle ScholarPubMed
7Peto, R, Doll, R. There is no such thing as aging. BMJ 1997; 315: 1030.CrossRefGoogle ScholarPubMed
8Krause, K-H. Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 2007; 42: 256–62.Google Scholar
9Harman, D. Aging: a theory on free radical radiation chemistry. J Gerontol 1956; 11: 298–300.Google Scholar
10Dowling, DK, Simmons, LW. Reactive oxygen species as universal constraints in life-history evolution. Proc R Soc Lond B Biol Sci 2009; 276: 1737–45.Google ScholarPubMed
11Sahin, E, DePinho, RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010; 464: 520–28.CrossRefGoogle ScholarPubMed
12St Laurent, G, Hammell, N, McCaffrey, TA. A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev 2010; 131: 299–305.Google Scholar
13Kenyon, CJ. The genetics of ageing. Nature 2010; 464: 504–12.Google Scholar
14Weismann, A. Collected essays on heredity and kindred biological problems. Oxford: Clarendon Press, 1889.Google Scholar
15Rose, MR, Burke, MK, Shahrestani, P, Mueller, LD. Evolution of ageing since Darwin. J Genet 2008; 87: 363–71.CrossRefGoogle ScholarPubMed
16Medawar, PB. An Unsolved Problem in Biology. London: Lewis, 1952.Google Scholar
17Williams, GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 11: 398–411.Google Scholar
18Kirkwood, TBL. Evolution of ageing. Nature 1977; 270: 301–4.CrossRefGoogle ScholarPubMed
19Haldane, JBS. New Paths in Genetics. London: Allen & Unwin, 1941.Google Scholar
20Hamilton, WD. The moulding of senescence by natural selection. J Theor Biol 1966; 12: 12–45.CrossRefGoogle ScholarPubMed
21Bonsall, MB. Longevity and ageing: appraising the evolutionary consequences of growing old. Phil Trans R Soc Lond B Biol Sci 2006; 361: 119–35.Google Scholar
22Bribiescas, RG, Ellison, PT. How hormones mediate trade-offs in human health and disease. In Stearns, SC, Koella, JC (eds), Evolution in Health and Disease, 2nd edn. Oxford: OUP, 2007; pp. 77–94.Google Scholar
23Partridge, L, Barton, NH. Optimality, mutation and the evolution of ageing. Nature 1993; 362: 305–11.CrossRefGoogle ScholarPubMed
24Rose, MR, Charlesworth, B. A test of evolutionary theories of senescence. Nature 1980; 287: 141–42.Google Scholar
25Promislow, D, Tatar, M, Khazaeli, AA, Curtsinger, JW. Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. Genetics 1996; 143: 839–48.CrossRefGoogle ScholarPubMed
26Shaw, F, Promislow, DE, Tatar, M, Hughes, KA, Geyer, CJ. Toward reconciling inferences concerning genetic variations in senescence in Drosophila melanogaster. Genetics 1999; 152: 553–66.CrossRefGoogle ScholarPubMed
27Hughes, KA, Charlesworth, B. A genetic analysis of senescence in Drosophila. Nature 1994; 367: 64–66.Google Scholar
28Hughes, KA, Alipaz, JA, Drnevich, JM, Reynolds, RM. A test of evolutionary theories of aging. Proc Natl Acad Sci USA 2002; 99: 14286–91.Google Scholar
29Westendorp, RGJ, Kirkwood, TBL. Human longevity at the cost of reproductive success. Nature 1998; 396: 743–46.Google Scholar
30Kirkwood, TBL, Rose, MR. Evolution of senescence. Phil Trans R Soc Lond B Biol Sci 1991; 332: 15–24.Google Scholar
31Stearns, SC, Ackermann, M, Doebeli, M, Kaiser, M. Experimental evolution of aging, growth, and reproduction in fruitflies. Proc Natl Acad Sci USA 2000; 97: 3309–13.CrossRefGoogle ScholarPubMed
32Keller, L, Genoud, M. Extraordinary lifespans in ants: a test of evolutionary theories of ageing. Nature 1997; 389: 958–60.Google Scholar
33Reznick, DN, Bryant, MJ, Roff, D, Ghalambor, GK, Ghalambor, DE. Effect of extrinsic mortality on the evolution of senescence in guppies. Nature 2004; 431: 1095–99.Google Scholar
34Bronikowski, AM, Promislow, DEL. Testing evolutionary theories of aging in wild populations. Trends Ecol Evol 2005; 20: 271–73.CrossRefGoogle ScholarPubMed
35Read, AF, Harvey, PH. Life-history differences among the eutherian radiations. J Zool Lond 1989; 219: 329–53.CrossRefGoogle Scholar
36Brunet-Rossinni, AK, Austad, SN. Ageing studies on bats: a review. Biogerontology 2004; 5: 211–22.Google Scholar
37Bourke, AFG, Franks, NR. Social Evolution in Ants. Princeton: Princeton University Press, 1995.Google Scholar
38Sherman, PW, Jarvis, JUM. Extraordinary life spans of naked mole rats. J Zool Lond 2002; 258: 307–11.Google Scholar
39Crozier, RH. Be social, live longer. Nature 1997; 389: 906–7.CrossRefGoogle Scholar
40Rose, MR, Mueller, LD. Evolution of human lifespan: past, future, and present. Am J Hum Biol 1998; 10: 409–20.Google Scholar
41Charlesworth, B. Evolution in Age-Structured Populations. Cambridge: CUP, 1980.Google Scholar
42Hawkes, K, O'Connell, JF, Blurton Jones, NG, Alvarez, H, Charnov, EL. Grandmothering, menopause, and the evolution of human life histories. Proc Natl Acad Sci USA 1998; 95: 1336–39.CrossRefGoogle ScholarPubMed
43Cant, MA, Johnstone, RA. Reproductive conflict and the separation of reproductive generations in humans. Proc Natl Acad Sci USA 2008; 105: 5332–36.Google Scholar
44Lee, RD. Rethinking the evolutionary theory of aging: transfers, not births, shape senescence in social species. Proc Natl Acad Sci USA 2003; 100: 9637–42.Google Scholar
45Kaplan, HS, Robson, AJ. The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers. Proc Natl Acad Sci USA 2002; 99: 10221–26.Google Scholar