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Growth hormone, aging and frailty

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  01 August 1999

Dr Finbarr C Martin  and
Dr Ian Sturgess
Dr Finbarr C Martin
Affiliation:
GKT School of Medicine, St. Thomas‘ Hospital, London, UK
Dr Ian Sturgess
Affiliation:
Kent and Canterbury Hospital, Canterbury, UK
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Abstract

Growth hormone and related growth factors are essential for normal childhood development, secretion rate then declining from early adulthood. Adults with growth hormone deficiency, e.g. after pituitary ablation, have many clinical features such as reduced muscle and bone mass which are also seen in healthy older people. In both cases, growth hormone treatment at least partly reverses these changes. This has led to the rather elegant notion that growth hormone decline may be responsible for age-related involution and death and raises the prospect of hormonal replacement therapy for aging and frailty.

Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 9 , Issue 3 , August 1999 , pp. 207 - 214
Copyright
© Cambridge University Press 1999

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