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Heterosexual spread of HIV infection

Published online by Cambridge University Press:  02 March 2009

Pamela Stratton  and
Nancy J Alexander
Pamela Stratton
Affiliation:
Contraceptive Development Branch, National Institute of Child Health and Human Development, Bethesda, USA
Nancy J Alexander*
Affiliation:
Contraceptive Development Branch, National Institute of Child Health and Human Development, Bethesda, USA
*
Nancy J Alexander, Chief, Contraceptive Development Branch, NICHD/CPR/CDB, 6100 Executive Boulevard, Room 8B13, Bethesda, MD 20892, USA.
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Extract

Sexual transmission is the most common route of spread of human immunodeficiency virus (HIV), with heterosexual transmission of HIV infection accounting for 90% of those infected in 1992 and over 75% of the 10–12 million of those infected to date worldwide. Yet, heterosexual transmission is poorly understood. Since HIV can be transmitted from HIV-infected people who are asymptomatic as well as from those who have the acquired immunodeficiency syndrome (AIDS), we must better define the potential for transmission of HIV from HIV-infected individuals as well as the factors which influence the susceptibility of HIV-uninfected individuals.

Type
Articles
Information
Reproductive Medicine Review , Volume 3 , Issue 2 , July 1994 , pp. 113 - 136
Copyright
Copyright © Cambridge University Press 1994

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References

1 Global Programme on AIDS. The current global situation of the HIV/AIDS pandemic. Press Release. Geneva: World Health Organization, 07 1992.Google Scholar
2 May, RM, Anderson, RM, Blower, SM. The epidemiology and transmission dynamics of HIV-AIDS. Daedalus 1989; 118: 163–201.Google Scholar
3 Holmberg, SD, Stewart, JA, Gerber, AR et al. Prior herpes simplex virus type 2 infection as a risk factor for HIV infection. JAMA 1988; 259: 1048–50.CrossRefGoogle ScholarPubMed
4 Peterman, TA, Stoneburner, RL, Allen, JR, Jaffe, HW, Curran, JW. Risk of human immunodeficiency virus transmission from heterosexual adults with transfusion-associated infection. JAMA 1988; 259: 55–58.CrossRefGoogle Scholar
5 Lawrence, DN, Jason, JM, Holman, RC, Murphy, JJ. HIV transmission from hemophilic men to their heterosexual partners. In: Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Alan R Liss, 1990: 35–53.Google Scholar
6 Staskewski, S, Schieck, E, Rehmet, S, Helm, EB, Stille, W. HIV transmission from a male after only two sexual contacts. Lancet 1987; ii: 628.CrossRefGoogle Scholar
7 Johnson, A, Peterick, A, Davidson, S et al. Transmission of HIV to heterosexual partners of infected men and women. IVth International Conference on AIDS, Stockholm, 06, 1988. Abstract 4058.Google Scholar
8 Alexander, NJ. Sexual transmission of human immunodeficiency virus: virus entry into the male and female genital tract. Fertil Steril 1990; 54: 1–18.Google ScholarPubMed
9 Peterman, TA. Facilitators of HIV transmission during sexual contact. In: Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Wiley-Liss, 1990: 55–68.Google Scholar
10 Padian, N. Heterosexual transmission: infectivity and risks. In: Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Wiley-Liss 1990: 25–34.Google Scholar
11 De Cock, KM, Adjorlolo, G, Ekpini, E et al. Epidemiology and transmission of HIV-2 - Why there is no HIV-2 pandemic. JAMA 1993; 270: 2083–86.CrossRefGoogle ScholarPubMed
12 Werner, BG, Grady, GF. Accidental hepatitis B surface antigen positive inoculations: use of e antigen to estimate infectivity. Ann Intern Med 1982; 97: 367–69.CrossRefGoogle ScholarPubMed
13 Seef, LB, Wright, EC, Zimmermena, HJ et al. Type B hepatitis after needlestick exposure: prevention with hepatitis B immune globulin: final report of the Veterans Administration Cooperative Study. Ann Intern Med 1978; 88: 285–93.CrossRefGoogle Scholar
14 Nicolosi, A. Epidemiologia dell' AIDS e del l'infezione da HIV: incidenza, fattori di rischio, transmissione. In: Cazzullo, L, Gala, C, Riccio, M eds. AIDS, insidia biologic e disagio psyicosocial Torino. ETET, 1990: 7–29.Google Scholar
15 Miller, CJ, Alexander, NJ, Sutjipto, S et al. Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. J Virol 1989; 63: 4277–84.CrossRefGoogle ScholarPubMed
16 Pearce-Pratt, R, Phillips, DM. Studies of adhesion of lymphocytic cells: implications for sexual transmission of human immunodeficiency virus. Biol Reprod 1993; 48: 431–45.CrossRefGoogle ScholarPubMed
17 Tan, X, Pearce-Pratt, R, Phillips, DM. Productive infection of a cervical epithelial cell line with human immunodeficiency virus: implications for sexual transmission. J Virol 1993; 67: 6447–52.CrossRefGoogle ScholarPubMed
18 Asjo, B, Morfeldt-Mansoni, L, Albert, J et al. Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection. Lancet 1986; ii: 660–62.CrossRefGoogle Scholar
19 Evans, LA, McHugh, TM, Stites, DO et al. Differential ability of human immunodeficiency virus isolates to predirtively infect human cells. J Immunol 1987; 138: 3415–18.CrossRefGoogle ScholarPubMed
20 Tersmette, M, Lange, JMA, De Goede, REY et al. Association between biologic properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality. Lancet 1989; i: 983–85.CrossRefGoogle Scholar
21 Wolinsky, SM, Wike, CM, Korber, BTM et al. Selective transmission of human immunodeficiency virus type-1: variants from mothers to infants. Science 1992; 255: 1134–37.CrossRefGoogle ScholarPubMed
22 Levy, JA. Human immunodeficiency viruses and the pathogenesis of AIDS. JAMA 1989; 261: 2997–3006.CrossRefGoogle ScholarPubMed
23 Vogt, MW, Witt, DJ, Craven, DE et al. Isolation patterns of human immunodeficiency virus from cervical secretions during the menstrual cycle of women at risk for the acquired immunodeficiency syndrome. Ann Intern Med 1987; 106: 380–82.CrossRefGoogle ScholarPubMed
24 Anderson, DJ, Wolff, H, Pudney, J et al. Presence of HIV in semen. In: Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Wiley-Liss, 1990: 167–80.Google Scholar
25 European Study Group on Heterosexual Transmission of HIV. Comparison of female-to-male and male-to-female transmission of HIV in 563 stable couples. Br Med J 1992; 304: 809–13.CrossRefGoogle Scholar
26 Saracco, A, Musicco, M, Nicolosi, A et al. Man-to-woman sexual transmission of HIV: Longitudinal study of 343 steady partners of infected men. J Acquir Immune Defic Syndr 1993; 6: 497–502.CrossRefGoogle ScholarPubMed
27 Seidlin, M, Vogler, M, Lee, E, Lee, YS, Dubin, N. Heterosexual transmission of HIV in a cohort of couples in New York City. AIDS 1993; 7: 1247–54.CrossRefGoogle Scholar
28 Ho, DD, Moudgil, T, Alam, M. Quantitation of human immunodeficiency virus type-1 in the blood of infected persons. N Engl J Med 1989; 321: 1621–25.CrossRefGoogle ScholarPubMed
29 Anderson, DJ, O'Brien, TR, Politch, JA et al. Effects of disease stage and zidovudine therapy on the detection of human immunodeficiency virus type-1 in semen. JAMA 1992; 267: 2769–74.CrossRefGoogle Scholar
30 Oxtoby, MJ. Human immunodeficiency virus and other viruses in human milk: placing the issues in broader perspective. Pediatr Infect Dis J 1988; 7: 825–35.CrossRefGoogle ScholarPubMed
31 Hamed, KA, Winters, MA, Holodny, M, Katzenstein, DA, Merigan, TC. Detection of human immunodeficiency virus type-1 in semen: effects of disease stage and nucleoside therapy. J Infect Dis 1993; 167: 798–802.CrossRefGoogle ScholarPubMed
32 O'Shea, S, Cordery, M, Barrett, WY et al. HIV excretion patterns and specific antibody responses in body fluids. J Med Virol 1990; 31: 291–96.CrossRefGoogle ScholarPubMed
33 Miller, CJ, Alexander, NJ, Vogel, P, Anderson, J, Marx, PA. Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques. J Med Primatol 1992; 21: 64–68.CrossRefGoogle Scholar
34 Pudney, J, Anderson, DJ. Orchitis and human immunodeficiency virus type-1 infected cells in reproductive tissues from men with acquired immune deficiency syndrome. Am J Pathol 1991; 139: 149–60.Google ScholarPubMed
35 Alexander, NJ, Anderson, DJ. Immunological factors in reproductive fitness. In: Austin, CR, Short, RV eds. Reproduction in mammals (Book 4, Reproductive fitness.), second edition. Cambridge: Cambridge University Press, 1984: 176–209.Google Scholar
36 Anderson, DJ, Politch, JA, Martinex, A et al. White blood cells and HIV-1 in semen from vasectomised seropositive men. Lancet 1991; 338: 573–74.CrossRefGoogle ScholarPubMed
37 Olsen, GP, Shields, JW. Seminal lymphocytes, plasma and AIDS. Nature 1984; 309: 116.CrossRefGoogle Scholar
38 Van Voorhis, BJ, Matinez, A, Mayer, K, Anderson, DJ. Detection of human immunodeficiency virus type-1 in semen from seropositive men using culture and polymerase chain reaction deoxyribonucleic acid amplification techniques. Fertil Steril 1991; 55: 588–94.CrossRefGoogle ScholarPubMed
39 Ashida, ER, Scofield, VL. Lymphocyte major histocompatibility complex-encoded class II structures may act as sperm receptors. Proc Natl Acad Sci USA 1987; 84: 3394–95.CrossRefGoogle ScholarPubMed
40 Voeller, B, Anderson, DJ. pH and related factors in the urogenital tract and rectum that affect HIV-1 transmission. Mariposa Occasional Paper # 16. New York: The Mariposa Education and Research Foundation, 1988: 1–12.Google Scholar
41 Bagasra, O, Freund, M, Widermann, J, Harley, G. Interaction of human immunodeficiency virus with human sperm in vitro. J Acquir Immun Defic Syndr 1988; 1: 431–35.Google ScholarPubMed
42 Mermin, JH, Holodniy, M, Katzenstein, DA, Merigan, TC. Detection of human immunodeficiency virus DNA and RNA in semen by the polymerase chain reaction. J Infect Dis 1991; 164: 769–72.CrossRefGoogle ScholarPubMed
43 Semprini, AE, Levi-Setti, P, Bozzo, M et al. Insemination of HIV-negative women with processed semen of HIV-positive partners. Lancet 1992; 340: 1317–19.CrossRefGoogle ScholarPubMed
44 Stewart, GJ, Cunningham, AL, Driscol, GL et al. Transmission of human T-cell lymphotropic virus type-III (HTL VIII) by artificial insemination by donor. Lancet 1985; ii: 581.CrossRefGoogle Scholar
45 Miller, CJ, Vogel, P, Alexander, NJ et al. Localization of SIV in the genital tract of chronically infected female rhesus macaques. Am J Path 1992; 141: 655–60.Google ScholarPubMed
46 Pomerantz, RJ, de la Monte, SM, Donegan, SP et al. Human immunodeficiency virus (HIV) infection of the uterine cervix. Ann Intern Med 1988; 108: 321–27.CrossRefGoogle ScholarPubMed
47 Van de Perre, P, de Clercq, A, Cogniaux-Leclerc, J et al. Detection of HIV p17 antigen in lymphocytes but not epithelial cells from cervicovaginal secretions of women seropositive for HIV: implications for heterosexual transmission of virus. Genitourin Med 1988; 64: 30–33.Google ScholarPubMed
48 Clemetson, DBA, Moss, GB, Willerford, DM et al. Detection of HIV DNA in cervical and vaginal secretions: prevalence and correlates among women in Nairobi, Kenya. JAMA 1993; 269: 2860–64.CrossRefGoogle ScholarPubMed
49 Miller, CJ, Vogel, P, Alexander, NJ et al. Pathology and localization of SIV in the reproductive tract of chronically infected male rhesus macaques. Lab Invest 1994; 70: 256–62.Google ScholarPubMed
50 Wagner, G. Vaginal transudation. In: Beller, FK, Schumacher, GFB eds. The biology of the fluids of the female genital tract. Amsterdam: Elsevier, 1979: 75–90.Google Scholar
51 Thompson, LA, Tomlinson, MJ, Barrati, CL et al. Positive immunoselection: a method of isolating leukocytes from leukocytic reacted human cervical mucus samples. Am J Reprod Immunol 1991; 26: 58–61.CrossRefGoogle ScholarPubMed
52 Alexander, NJ, Anderson, DJ. Immunology of semen. Fertil Steril 1987; 47: 192–205.Google ScholarPubMed
53 Lo Caputo, S, Angarano, G, Maggi, P, Federico, M, Buccoliero, G, Pastore, G. Efficacy of therapy with zidovudine in preventing heterosexual transmission of HIV. Second International Symposium on AIDS and Reproduction. Nice, France, 6–8 05 1993.Google Scholar
54 Krieger, JN, Coombs, RW, Collier, AC et al. Recovery of human immunodefieincy virus type-1 from semen: minimal impact of stage of infection and current antiviral chemotherapy. J Infect Dis 1991; 163: 386–88.CrossRefGoogle ScholarPubMed
55 Wainberg, MA, Beaulieu, R, Tsoukas, C, Thomas, R. Detection of zidovudine-resistant variants of HIV-1 in genital fluids. AIDS 1993; 7: 433–34.CrossRefGoogle ScholarPubMed
56 Klenerman P. Heterosexual transmission of HIV-1 variants coding for loss of sensitivity to zidovudine. Brighton Workshop, Brighton, UK, 09 1993. Abstract 33.Google Scholar
57 Wofsy, CB, Cohen, JB, Hauer, LB et al. Isolation of AIDS-associated retrovirus from genital secretions of women with antibodies to the virus. Lancet 1986; i: 527–29.CrossRefGoogle Scholar
58 Bagasra, O, Freund, M. In vitro and in vivo studies of HIV-1 and human sperm. In: Alexander, NJ, Gabelnick, HL, Spieler, J eds. The heterosexual transmission of AIDS. New York: Wiley-Liss, 1990: 155–65.Google Scholar
59 Henin, Y, Mandelbrot, L, Henrion, R et al. Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women. J Acquir Immune Defic Syndr 1993; 6: 72–75.Google ScholarPubMed
60 Zagury, D, Bernard, J, Leibowitch, J et al. HTLV-III in cells cultured from semen of two patients with AIDS. Science 1984; 226: 449–51.CrossRefGoogle ScholarPubMed
61 Ho, DD, Schooley, RT, Rota, TR, Kaplan, JC, Flynn, T. HTLV-III in semen and blood of a healthy homosexual man. Science 1984; 226: 451–53.CrossRefGoogle ScholarPubMed
62 Schaffner, CP, Plescia, OJ, Pontani, D et al. Anti-viral activity of amphotericin B methyl ester: Inhibition of HTLV-III replication in cell culture. Biochem Pharmacol 1986; 35: 4110–13.CrossRefGoogle ScholarPubMed
63 Brooks Jackson, J, Coombs, RW, Sannerud, K et al. Rapid and sensitive viral culture method for human immunodeficiency virus type-1. J Clin Micro 1988; 26: 1416–18.CrossRefGoogle Scholar
64 Lillo, FB, Cao, Y, Concedi, DR, Varnier, OE. Improved detection of serum HIV p24 antigen after acid dissociation of immune complexes. AIDS 1993; 7: 1331–36.CrossRefGoogle ScholarPubMed
65 Chin, J. Epidemiology: Current and future dimensions of the HIV/AIDS pandemic in women and children. Lancet 1990; 336: 221–24.CrossRefGoogle Scholar
66 Centers for Disease Control and Prevention. Acquired Immunodeficiency Syndrome, 1992. MMWR 1993; 42: 547–57.Google Scholar
67 Guinan, ME, Hardy, A. Epidemiology of AIDS in women in the United States. JAMA 1987; 257: 2039–42.CrossRefGoogle ScholarPubMed
68 Centers for Disease Control and Prevention HIV/AIDS Surveillance Report, 1993; 5(3): 1–18.Google Scholar
69 Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Alan R Liss, 1990.Google Scholar
70 Allen, JR. Heterosexual transmission of human immunodeficiency virus (HIV) in the United States. Bull N Y Acad Med 1988; 64: 464–79.Google ScholarPubMed
71 Cates, W, Stone, KM. Family planning, sexually transmitted diseases and contraceptive choice: a literature update — Part I. Family Plann Perspect 1992; 24: 75–84.CrossRefGoogle Scholar
72 Padian, N. Heterosexual transmission of acquired immunodeficiency syndrome: International perspectives and national projections. Rev Infect Dis 1987; 9: 947–60.CrossRefGoogle ScholarPubMed
73 Hunt, MM. Sexual behavior in the 1970s. Chicago, IL: Playboy Press, 1974.Google Scholar
74 Bolling, DR. Prevalence, goals and complications of heterosexual anal intercourse in a gynecologic population. J Reprod Med 1977; 19: 120–24.Google Scholar
75 Bolling, DR. Heterosexual anal intercourse: a review and survey of prevalence, denial and patterns in an OB/GYN population. University of Texas Health Science Center at San Antonio, Texas (unpublished report), 1988.Google Scholar
76 Bolling, DR, Voeller, B. AIDS and heterosexual anal intercourse. JAMA 1987; 258: 474.Google ScholarPubMed
77 Reinisch, JM, Sanders, SA, Ziemba-Davis, M. Self-labeled sexual orientation and sexual behavior: considerations for STD-related biomedical research and education. Pers Behav Med (in press).Google Scholar
78 Evans, BA, McLean, KA, Dawson, SG et al. Trends in sexual behaviours and risk factors for HIV infection among homosexual men, 1984–7. Br Med J 1989; 298: 215–18.CrossRefGoogle ScholarPubMed
79 van Griensven, GJP, de Vroome, EMM, Goudsmit, J, Coutinho, RA. Changes in sexual behaviour and the fall in incidence of HIV infection among homosexual men. Br Med J 1989; 298: 218–21.CrossRefGoogle ScholarPubMed
80 Padian, NS. Prostitute women and AIDS: epidemiology. AIDS 1988; 2: 415–19.CrossRefGoogle ScholarPubMed
81 Rosenblum, L, Darrow, W, Witte, J et al. Sexual practices in the transmission of hepatitis B virus and prevalence of hepatitis delta virus infection in female prostitutes in the United States. JAMA 1992; 267: 2477–81.CrossRefGoogle ScholarPubMed
82 Voeller, B. AIDS and heterosexual anal intercourse. Arch Sex Behav 1991; 20: 233–76.CrossRefGoogle ScholarPubMed
83 Moyer, MP, Huot, RI, Ramirez, A Jr et al. Infection of human gastrointestinal cells by HIV-1. AIDS Res Hum Retroviruses 1990; 12: 1409–15.CrossRefGoogle Scholar
84 Mathijs, JM, Hing, M, Grierson, J et al. HIV infection of rectal mucosa. Lancet 1988; i: 1111.CrossRefGoogle Scholar
85 Amerongen, HM, Weltzin, R, Farnet, CM et al. Transepithelial transport of HIV-1 by intestinal M cells: a mechanism of transmission of AIDS. J Acquir Immune Defic Syndr 1991; 4: 760–65.Google ScholarPubMed
86 Lehner, T, Brookes, R, Panagiotidi, C et al. T- and B-cell functions and epitope expression nonhuman primates immunized with simian immunodeficiency virus antigen by the rectal route. Proc Natl Acad Sci USA 1993; 90: 8638–42.CrossRefGoogle ScholarPubMed
87 Moore, BE, Flaitz, CM, Coppenhaver, DH et al. HIV recovery from saliva before and after dental treatment: inhibitors may have critical role in viral inactivation. J Am Dent Assoc 1993; 124: 67–74.CrossRefGoogle ScholarPubMed
88 Piazza, M, Chirianni, A, Liuzzi, G et al. [HIV-1 proviral DNA sequences in the saliva of patients with HIV infection]. Boll Soc Ital Biol Sper 1992; 68: 475–81.Google ScholarPubMed
89 Goopman, JE, Salahuddin, SZ, Sarngadharan, MG et al. HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk of AIDS. Science 1984; 226: 447–49.CrossRefGoogle Scholar
90 Samuel, MC, Hessol, N, Shiboski, S et al. Factors associated with human immunodeficiency virus seroconversion in homosexual men in three San Francisco cohort studies, 1984–1989. J Acquir Immune Defic Syndr 1993; 6: 303–12.Google ScholarPubMed
91 Jennings, M, Lerche, N, Tillery, S et al. Infection with simian immunodeficiency virus (SIV) via conjunctival and oral mucosae in a newborn rhesus macaque. Vth International Conference on AIDS, Montreal, Canada, 1989 (abstract).Google Scholar
92 Stoltenberg, JL, Osborn, JB, Pihlstrom, BL et al. Prevalence of periodontal disease in a health maintenance organization and comparisons to the national survey of oral health. J Peridontal 1993; 64: 853–58.Google Scholar
93 Platzner, W, Poisel, S, Hafez, ESE. Functional anatomy of the human vagina. In: Hafez, ESE, Evans, TN eds. Human reproductive medicine: the human vagina. New York: North-Holland Publishing Company, 1978: 39–54.Google Scholar
94 Burgos, MH, Roig de Vargas-Linares CD. Ultrastructure of the vaginal mucosa. In: Hafez, ESE, Evans, TN eds. Human reproductive medicine: the human vagina. New York: North-Holland Publishing Company, 1978: 63–93.Google Scholar
95 Miller, CJ, McGhee, JR, Gardner, MB. Mucosal immunity, HIV transmission, and AIDS. Lab Invest 1993; 68: 129–45.Google ScholarPubMed
96 Goldacre, MJ, Loudon, N, Watt, B et al. Epidemiology and clinical significance of cervical erosion in women attending a family planning clinic. Br Med J 1978; 17: 747–50.Google Scholar
97 Holmes, KK, Kriess, J. Heterosexual transmission of human immunodeficiency virus: overview of a neglected aspect of the AIDS epidemic. J Acquir Immune Defic Syndr 1988; 1: 602–10.Google ScholarPubMed
98 Moss, GB, Clemetson, D, D'Costa, L et al. Association of cervical ectopy with heterosexual transmission of human immunodeficiency virus: results of a study of couples in Nairobi, Kenya. J Infect Dis 1991; 164: 588–91.CrossRefGoogle ScholarPubMed
99 Louv, WC, Austin, H, Perlman, J, Alexander, WJ. Oral contraceptive use and the risk of chylamydial and gonococcal infections. Am J Obstet Gynecol 1989; 160: 396–402.CrossRefGoogle ScholarPubMed
100 Blum, M, Gilerovitch, M, Menaim, J, Appelbaum, T. The correlation between chlamydial antigen, antibody, vaginal colonization and contraceptive method in young, unmarried women. Adv Contracept 1990; 6: 41–45.CrossRefGoogle ScholarPubMed
101 Paavonen, J, Stevens, CE, Wolner-Hanssen, P et al. Colposcopic manifestations of cervical and vaginal infections. Obstet Gynecol Surv 1988; 43: 1048–50.CrossRefGoogle ScholarPubMed
102 Roddy, RE, Cordero, M, Cordero, C, Fortney, JA. A dosing study of nonoxynol-9 and genital irritation. Int J STD AIDS 1993; 4: 165–70.CrossRefGoogle ScholarPubMed
103 Bernstein, GS, Nakamura, RM, Frezieres, R, Coulson, AH, Walsh, T. Vaginal trauma related to use of contraceptive diaphragms. Relevance to transmission of HIV. IXth International Conference on AIDS, Berlin, 7–11 06 1993 (poster).Google Scholar
104 Holmberg, SD, Horsburgh, CR, Ward, JW, Jaffe, HW. Biologic factors in the sexual transmission of human immunodeficiency virus. J Infect Dis 1989; 160: 116–25.CrossRefGoogle ScholarPubMed
105 Edwards, JNT, Morris, HB. Langerhans cells and lymphocyte subsets in the female genital tract. Br J Obstet Gynaecol 1985; 92: 973–82.CrossRefGoogle ScholarPubMed
106 Bjercke, S-, Scott, H, Braathen, LR, Thorsby, E. HLA-DR-expressing Langerhans-like cells in vaginal and cervical epithelium. Acta Obstet Gynecol Scand 1983; 62: 585–89.CrossRefGoogle ScholarPubMed
107 Morris, HHB, Gatter, KC, Stein, H, Mason, DY. Langerhans cells in human cervical epithelium: An immunohistologic study. Br J Obstet Gynaecol 1983; 90: 321–27.CrossRefGoogle Scholar
108 Parr, MB, Kepple, L, Parr, EL. Antigen recognition in the female reproductive tract: II: endocytosis of horseradish peroxidase by Langerhans cells in murine vaginal epithelium. Biol Reprod 1991; 45: 261–65.CrossRefGoogle ScholarPubMed
109 Gomez, E, Ortiz, V, Saint-Martin, B et al. Hormonal regulation of the secretory IgA (sIgA) system: estradiol- and progesterone-induced changes in sIgA in parotid saliva along the menstrual cycle. Amer J Reprod Immunol 1993; 29: 219–23.CrossRefGoogle ScholarPubMed
110 Parr, EL, Parr, MB. A comparison of antibody titers in mouse uterine fluid after immunization by several routes, and the effects of the uterus on antibody titers in vaginal fluids. J Repro Fertil 1990; 9: 619–25.CrossRefGoogle Scholar
111 Jalanti, R, Isliker, H. Immunoglobulins in human cervico-vaginal secretions. Int Arch Aller Appl Immunol 1977; 53: 402–409.CrossRefGoogle ScholarPubMed
112 Kutteh, WH, Kutteh, C, Blackwell, RE et al. Secretory immune system of the female reproductive tract. II: Local immune system in normal and infected fallopian tube. Fertil Steril 1990; 54: 51–55.CrossRefGoogle ScholarPubMed
113 Chippenfield, EJ, Evans, BA. The influence of local infection on immunoglobulin formation in the human endocervix. Clin Exp Immunol 1972; 11: 219–33.Google Scholar
114 Merriman, H, Woods, S, Winter, C et al. Secretory IgA antibody in cervicovaginal secretions from women with genital infection due to herpes simplex virus. J Infect Dis 1984; 149: 505–10.CrossRefGoogle ScholarPubMed
115 Cunningham, DS, Fulgham, DL, Rayl, DL, Hansen, KA, Alexander, NJ. Antisperm antibodies to sperm surface antigens in women with genital tract infection. Am J Obstet Gynecol 1991; 164: 791–96.CrossRefGoogle ScholarPubMed
116 Ogra, PL, Ogra, SS. Local antibody response to polio vaccine in the human female genital tract. J Immunol 1973; 110: 1307–11.CrossRefGoogle Scholar
117 Miller, CJ, Alexander, NJ, McChesney, MB. Vaccines to prevent sexually transmitted diseases: the challenge of generating protective immunity at genital mucosal surfaces. In: Ada, G ed. Vaccination strategies to control infections. Austin, TX: RG Landes, 1994: 193–212.Google Scholar
118 Kang, CY, Nara, P, Chamat, S et al. Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans. Proc Natl Acad Sci USA 1991; 88: 6171–75.CrossRefGoogle ScholarPubMed
119 Bolognesi, DP. Do antibodies enhance the infection of cells by HIV? Nature 1989; 340: 431.CrossRefGoogle ScholarPubMed
120 Wagner, G and Levin, RJ. Vaginal fluid. In: Hafez, ESE, Evans, TN eds. Human reproductive medicine: the human vagina. New York: North-Holland, 1978: 121–37.Google Scholar
121 Bergh, PA. Vaginal changes with aging. In: Breen, JL ed. The gynecologist and the older patient. Rockville, MD: Aspen, 1988: 299–311.Google Scholar
122 Rebar, RW. Practical evaluation of hormonal status. In: Yen, SSC, Jaffe, RB eds. Reproductive endocrinology – physiology, pathophysiology and clinical management. Philadelphia: WB Saunders, 1986: 683–733.Google Scholar
123 Moghissi, KS. Cyclic changes of cervical mucus in normal and progestin-treated women. Fertil Steril 1966; 17: 63–75.CrossRefGoogle ScholarPubMed
124 Wolf, DP, Blasco, L, Khan, MA, Litt, M. Human cervical mucus V. Oral contraceptives and mucus rheologic properties. Fertil Steril 1979; 32: 166–69.CrossRefGoogle ScholarPubMed
125 Nugent, RP, Krohn, MA, Hillier, SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol 1991; 29: 297–301.CrossRefGoogle ScholarPubMed
126 Larsen, B, Galask, RP. Vaginal microbial flora: Composition and influences of host physiology. Ann Inter Med 1982; 96: 926–30.CrossRefGoogle ScholarPubMed
127 Larsen, B. Vaginal Flora in Health and Disease. Clin Obstet Gynecol 1993; 36: 107–121.CrossRefGoogle ScholarPubMed
128 McGroaty, JA, Tomeczek, L, Pond, DG, Reid, G, Bruce, AW. Hydrogen peroxide production by Lactobacillus species: correlation with susceptibility to the spermicidal compound nonoxynol-9. J Infect Dis 1992; 165: 1142–44.CrossRefGoogle Scholar
129 Bartlett, JF, Onderdonk, AB, Drude, E et al. Quantitative bacteriology of the vaginal flora. J Infect Dis 1977; 136: 271–77.CrossRefGoogle ScholarPubMed
130 Ongradi, J, Ceccherini-Nelli, L, Pistell, M, Spector, S, Bendinelli, M. Acid sensitivity of cell-free and cell-associated HIV-1: clinical implications. AIDS Res Hum Retroviruses 1990; 6: 1433–36.CrossRefGoogle ScholarPubMed
131 Rogosa, M, Sharpe, ME. Species differentiation of human vaginal lactobacilli. J Gen Microbiol 1960; 23: 197–202.CrossRefGoogle ScholarPubMed
132 Eschenbach, DA, Davick, PR, Williams, BL et al. Prevalence of hydrogen peroxide-producin. Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol 1989; 27: 251–56.CrossRefGoogle ScholarPubMed
133 Larsen, B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993; 36: 107–21.CrossRefGoogle ScholarPubMed
134 Lang, WR. Vaginal acidity and pH: a review. Obstet Gynecol Surv 1955; 10: 546–55.CrossRefGoogle ScholarPubMed
135 Semmens, JR, Tsai, CC, Semmens, EC, Loadholt, CB. Effects of estrogen therapy on vaginal physiology during menopause. Obstet Gynecol 1985; 66: 15–18.Google Scholar
136 Kistner, RW. Physiology of the vagina. In: Hafez, ESE, Evans, TN eds. Human reproductive medicine: the human vagina. New York: North-Holland, 1978: 109–20.Google Scholar
137 Hill, JA, Anderson, DJ. Human vaginal leukocytes and the effects of vaginal fluid on lymphocyte and macrophage defense functions. Am J Obstet Gynecol 1992; 166: 720–26.CrossRefGoogle ScholarPubMed
138 Larsen, B, Galask, RP. Vaginal microbial flora: composition and influences of host physiology. Ann Intern Med 1982; 96: 926–30.CrossRefGoogle ScholarPubMed
139 Raudrant, D, Frappart, L, De Haas, P, Thoulaons, JM, Charvet, F. Study of the vaginal mucous membrane following tampon utilization: aspect on colposcopy, scanning electron microscopy and transmission electron microscopy. Eur J Obstet Gynecol Reprod Biol 1989; 31: 53–65.CrossRefGoogle ScholarPubMed
140 Webster, A, Lee, CA, Cook, DG et al. Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet 1989; ii: 63–66.CrossRefGoogle Scholar
141 Pudney, J, Oneta, M, Mayer, K, Seage, G, Anderson, D. Pre-ejaculatory fluid as a potential vector for sexual transmission of HIV-1. Lancet 1992; 340: 1470.CrossRefGoogle ScholarPubMed
142 Musicco, M, Nicolosi, A, Saracco, A, Lazzarin, A. The role of contraceptives in HIV sexual transmission. Second International Symposium on AIDS and Reproduction. Nice, France, 6–8 05 1993.Google Scholar
143 Fox, CA, Meldrum, SJ, Watson, BW. Continuous measurement by radio-telemetry of vaginal pH during human coitus. J Reprod Fert 1973; 33: 69–75.CrossRefGoogle ScholarPubMed
144 Katz, DF, Dunmire, EN. Cervical mucus. Problems and opportunities for drug delivery via the vagina and cervix. Adv Drug Deliv Rev 1993; 11: 385–401.CrossRefGoogle Scholar
145 Saxena, S, Jha, P, Farooq, A. Purification and characterization of an immunosuppressive factor from normal human seminal plasma. J Reprod Immunol 1988; 13: 133–46.CrossRefGoogle ScholarPubMed
146 Tarter, TH, Cunningham-Rundles, S, Koide, SS. Suppression of natural killer cell activity by human seminal plasma in vitro: identification 19-OH-PGE as the suppressor factor. J Immunol 1986; 136: 2862–67.CrossRefGoogle ScholarPubMed
147 Liang, ZG, Kamada, M, Koide, SS. Binding of a specific subclass of immunoglobulins by a human seminal plasma component. Andrologia 1993; 25: 279–82.CrossRefGoogle ScholarPubMed
148 Laga, M, Manoka, A, Kivuvu, M, Malele, B, Piot, P. Nonulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 1993; 7: 95–102.CrossRefGoogle ScholarPubMed
149 Plummer, FA, Simonsen, JN, Cameron, DW et al. Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J Infect Dis 1991; 163: 233–39.CrossRefGoogle ScholarPubMed
150 Latif, AS, Katzenstein, DA, Bassett, MT et al. Genital ulcers and transmission of HIV among couples in Zimbabwe. AIDS 1989; 3: 519–23.Google ScholarPubMed
151 European Working Group on HIV Infection in Female Prostitutes. HIV infection in European female sex workers: epidemiological link with use of petroleum-based lubricants. AIDS 1993; 7: 401–408.CrossRefGoogle Scholar
152 Kreiss, JK, Koech, D, Plummer, FA et al. AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa. N Engl J Med 1986; 314: 414–18.CrossRefGoogle ScholarPubMed
153 Cameron, DW, Simonsen, JN, D'Costa, LJ et al. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. Lancet 1989; ii: 403–407.CrossRefGoogle Scholar
154 Morelli, AE, Sananes, C, Di Paola, G, Paredes, A, Fainboi, L. Relationship between types of human papillomavirus and Langerhans' cells in cervical condyloma and intraepithelial neoplasia. Am J Clin Pathol 1993; 99: 200–206.CrossRefGoogle ScholarPubMed
155 Spinollo, A, Teni, P, Zappatore, R et al. Langerhans' cell counts and cervical intraepithelial neoplasia in women with human immunodeficiency virus infection. Gynecol Oncol 1993; 48: 210–13.CrossRefGoogle Scholar
156 Richart, RM, Wright, TC. Controversies in the management of low grade cervical intraepithelial neoplasia. Cancer 1993; 71: 1413–21.CrossRefGoogle ScholarPubMed
157 Stratton, P and Ciacco, KH. Cervical neoplasia in the patient with HIV infection. Curr Opin Obstet Gynecol 1994; 6: 86–91.CrossRefGoogle ScholarPubMed
158 Knuth, K, Amiji, M, Robinson, JR. Hydrogel delivery systems for vaginal and oral applications. Formulation and biological considerations. Adv Drug Deliv Rev 1993; 11: 137–67.CrossRefGoogle Scholar
159 Okamura, K, Furukawa, K, Nakakuki, M, Yamada, K, Suzuki, M. Natural killer cell activity during pregnancy. Am J Obstet Gynecol 1984; 149: 396–99.CrossRefGoogle ScholarPubMed
160 Gregory, CD, Shah, LP, Lee, H, Scott, IV, Golding, PR. Cytotoxic reactivity in human natural killer (NK) cells during normal pregnancy: a longitudinal study. J Clin Lab Immunol 1985; 18: 175–81.Google ScholarPubMed
161 Lee, H, Gregory, CD, Rees, GB, Scott, IV, Golding, PR. Cytotoxic activity and phenotypic analysis of natural killer cells in early normal human pregnancy. J Reprod Immunol 1987; 12: 35–47.CrossRefGoogle ScholarPubMed
162 Gregory, CD, Lee, H, Scott, IV, Golding, PR. Phenotypic heterogeneity and recycling capacity of natural killer cells in normal human pregnancy. J Reprod Immunol 1987; 11: 135–45.CrossRefGoogle ScholarPubMed
163 Szekeres, J, Fabian, G, Pacsa, AS, Pejtsik, B. Dialyzable serum factors alter cellular immunity in pregnancy. Experientia 1981; 37: 515–16.CrossRefGoogle Scholar
164 Szekeres, J, Csernus, V, Pejtsik, S, Emody, L, Pacsa, AS. Progesterone as an immunologic blocking factor in human pregnancy serum. J Reprod Immunol 1981; 3: 333–39.CrossRefGoogle ScholarPubMed
165 Szekeres-Bartho, J, Hadnagy, J, Pacsa, AS. The suppressive effects of progesterone on lymphocyte cytotoxicity: unique progesterone sensitivity of pregnancy lymphocytes. J Reprod Immunol 1985; 7: 121–28.CrossRefGoogle ScholarPubMed
166 Sukke, AN, Jones, DB, Wood, PJ. Hormonal modulation of human natural killer cell activity in vitro. J Reprod Immunol 1985; 7: 105–10.Google Scholar
167 Uksila, J. Human NK cell activity in not inhibited by pregnancy and cord serum factors and female steroid hormones in vitro. J Reprod Immunol 1985; 7 111–20.CrossRefGoogle Scholar
168 Teepe, AG, Allen, LB, Wordinger, RJ, Harris, EF. Effect of the estrous cycle on susceptibility of female mice to intravaginal inoculation of herpes simplex virus type 2 (HSV-2). Antiviral Res 1990; 14: 227–35.CrossRefGoogle ScholarPubMed
169 Richardson, JL, Illum, L. Routes of delivery: case studies – the vaginal route of peptide and protein drug delivery. Adv Drug Del Rev 1992; 8: 341–66.CrossRefGoogle Scholar
170 McGregor, JA, Hammill, HA. Contraception and sexually transmitted diseases: interactions and opportunities. Am J Obstet Gynecol 1993; 168: 2033–41.CrossRefGoogle ScholarPubMed
171 Tuffrey, M, Taylor-Robinson, D. Progesterone as a key factor in the development of a mouse model for genital tract infection with C. trachomatis. FEMS Microbiol Lett 1981; 12: 111–15.CrossRefGoogle Scholar
172 Rank, RG, White, HJ Jr, Pasley, JN, Barren, AL. Effect of estradiol on chlamydial genital infection of female guinea pigs. Infect Immunol 1982; 38: 699–705.CrossRefGoogle ScholarPubMed
173 Arya, LP, Mallinson, H, Goddard, AD. Epidemiological and clinical correlates of chlamydial infection of the cervix. Br J Vener Dis 1981; 57: 118–24.Google ScholarPubMed
174 Rank, RG, Barron, AI. Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections. Infect Immunol 1987; 55: 2317–19.CrossRefGoogle ScholarPubMed
175 Bose, Sk, Goswami, PC. Enhancement of adherence and growth of Chlamydia trachomatis by estrogen treatment of HeLa cells. Infect Immunol 1986; 53: 646–50.CrossRefGoogle ScholarPubMed
176 Maslow, AS, Davis, CH, Choong, J, Wyrick, PB. Estrogen enhances attachment of Chlamydia trachomatis to human endometrial cells in vitro. Am J Obstet Gynecol 1988; 159: 1006–14.CrossRefGoogle Scholar
177 Wolner-Hanssen, P, Svensson, L, Mardh, P-A, Westrom, L. Laparoscopic findings and contraceptive use in women with signs and symptoms suggestive of acute salpingitis. Obstet Gynecol 1985; 66: 233–38.Google ScholarPubMed
178 Wolner-Hanssen, P. Oral contraceptive use modifies the manifestations of pelvic inflammatory disease. Br J Obstet Gynaecol 1986; 93: 619–35.CrossRefGoogle ScholarPubMed
179 Moi, H. Prevalence of bacterial vaginosis and its association with gonadal infections, inflammation, and contraceptive methods in women attending sexually transmitted disease and primary health clinics. Int J STD AIDS 1990; 1: 86–94.CrossRefGoogle Scholar
180 Plummer, FA, Simonsen, JN, Cameron, DW et al. Cofactors in male-female sexual transmission of human immunodeficiency virus type-1. J Infect Dis 1991; 163: 233–39.CrossRefGoogle ScholarPubMed
181 Carael, M, Van de Perre, PH, Lepage, PH et al. Human immunodeficiency virus transmission among heterosexual couples in Central Africa. AIDS 1988; 2: 201–205.Google ScholarPubMed
182 European Study Group. Risk factors for male to female transmission of HIV. Br Med J 1989; 298: 411–15.CrossRefGoogle Scholar
183 Hira, SK, Kamanaga, J, Macuacua, R, Feldblum, PJ. Oral contraceptive use and HIV infection. Int J STD AIDS 1990; 1: 447–48.CrossRefGoogle ScholarPubMed
184 Simonsen, JN, Plummer, FA, Ngugi, EN et al. HIV infection among lower socioeconomic strata prostitutes in Nairobi. AIDS 1990; 4: 39–44.Google ScholarPubMed
185 Shoupe, D, Mishell, DR, Bopp, B, Fielding, M. The significance of bleeding patterns in Norplant implant users. Obstet Gynecol 1991; 77: 246–60.CrossRefGoogle ScholarPubMed
186 World Health Organization Task Force. A multicentered Phase III comparative clinical trial of depot-medroxyprogesterone acetate given three-monthly at doses of 100 mg or 150 mg: 1. Contraceptive efficacy and side effects. Contraception 1986; 34: 223–35.CrossRefGoogle Scholar
187 Roy, S. Nonbarrier contraceptives and vaginitis and vaginosis. Am J Obstet Gynecol 1991; 165: 1240–44.CrossRefGoogle ScholarPubMed
188 Grimes, DA, Cates, W Jr. Family planning and sexually transmitted diseases. In: Holmes, KK, Mardh, PA, Sparling, PF eds. Sexually transmitted diseases. Second edition. New York: McGraw-Hill, 1990: 1087–99.Google Scholar
189 Miller, CJ, Alexander, NJ, Gettie, A, Hendrickx, AG, Marx, PA. The effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques. Fert Steril 1992; 57: 1126–128.CrossRefGoogle ScholarPubMed
190 Zekeng, L, Feldblum, PJ, Oliver, RM, Kaptue, L. Barrier contraceptive use and HIV infection among high-risk women in Cameroon. AIDS 1993; 7: 725–31.CrossRefGoogle ScholarPubMed
191 Niruthisard, S, Roddy, RE, Chutivongse, S. The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa. Sex Transm Dis 1991; 18: 176–79.CrossRefGoogle ScholarPubMed
192 Kreiss, J, Ngugi, E, Holmes, KK et al. Efficacy of nonoxynol-9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. JAMA 1992; 268: 477–82.CrossRefGoogle ScholarPubMed
193 Rosenberg, MJ, Rojanapithayakom, W, Feldblum, PJ et al. Effect of the contraceptive sponge on chlamydial infection, gonorrhea, and candidiasis: a comparative clinical trial. JAMA 1987; 257: 2308–12.CrossRefGoogle ScholarPubMed
194 Klebanoff, SJ. Effects of the spermicidal agent nonoxynol-9 on vaginal microbial flora. J Infect Dis 1992; 165: 19–25.CrossRefGoogle ScholarPubMed
195 Hooton, TM, Hillier, S, Johnson, C, Roberts, PL, Stamm, WE. Escherichia coli bacteriuria and contraceptive method. JAMA 1991; 265: 64–69.CrossRefGoogle ScholarPubMed
196 Mench, TR, Whaley, KJ, Mandrell, TD et al. The cat/feline immunodeficiency virus model for transmucosal transmission of AIDS: nonoxynol-9 contraceptive jelly blocks transmission by an infected cell inoculum. AIDS 1993; 7: 797–802.CrossRefGoogle Scholar
197 Roy, S. Nonbarrier contraceptives and vaginitis and vaginosis. Am J Obstet Gynecol 1991; 165: 1240–44.CrossRefGoogle ScholarPubMed
198 Tietze, C, Lewit, S. Evaluation of intrauterine devices: Ninth progress report of the Cooperative Statistical Program. Stud Family Plann 1970; 55: 1–40.CrossRefGoogle Scholar
199 Mishell, DR, Bell, JH, Good, RG, Moyer, DL. The intrauterine device: a bacteriologie study of the endometrial cavity. Am J Obstet Gynecol 1966; 96: 119–26.CrossRefGoogle Scholar
200 Farley, TMM, Rosenberg, MJ, Rowe, P, Chen, J-H, Meirik, O. Intrauterine devices and pelvic inflammatory disease: an international perspective. Lancet 1992; 339: 785–88.CrossRefGoogle ScholarPubMed
201 Stratton, P, Alexander, NJ. Prevention of sexually transmitted infections. Physical and chemical barrier methods. Infect Dis Clin North Am 1993; 7: 841–59.CrossRefGoogle ScholarPubMed
202 Carey, RF, Herman, WA, Retta, SM et al. Effectiveness of condoms as a barrier to human immunodeficiency virus-sized particles under conditions of simulated use. Sex Transm Dis 1992; 19: 230–34.CrossRefGoogle ScholarPubMed
203 Judson, FN, Ehret, JM, Bodin, GF et al. In vitro evaluations of condoms with and without nonoxynol-9 as physical and chemical barriers against chlamydia trachomatis, herpes simplex virus type-2 and human immunodeficiency virus. Sex Transm Dis 1989; 16: 51–56.CrossRefGoogle ScholarPubMed
204 Minuk, GY, Bohme, CE, Bowen, TJ. Condoms and hepatitis B virus infection. Ann Intern Med 1986; 104: 584.CrossRefGoogle ScholarPubMed
205 Minuk, GY, Bohme, CE, Bowen, TJ, Hoar, DI, Cassol, S. Condoms and the prevention of AIDS [letter]. JAMA 1986; 256: 1443.CrossRefGoogle Scholar
206 Conant, MA, Spicer, DW, Smith, CD. Herpes simplex virus transmission: condom studies. Sex Transm Dis 1984: 11: 94–95.CrossRefGoogle ScholarPubMed
207 Free, MJ, Hutchings, J. Condom quality management. In: Alexander, NJ, Gabelnick, HL, Spieler, JM eds. Heterosexual transmission of AIDS. New York: Wiley-Liss, 1990: 379–97.Google Scholar
208 Russell-Brown, P, Piedrahita, C, Foldesy, R et al. Comparison of condom breakage during human use with performance in laboratory testing. Contraception 1992; 45: 429–37.CrossRefGoogle ScholarPubMed
209 Drew, L, Blair, M, Miner, RC, Conant, M. Evaluation of the virus permeability of a new condom for women. Sex Transm Dis 1992; 19: 230–34.Google Scholar
210 Update: barrier protection against HIV infection and other sexually transmitted diseases. MMWR 1993; 42: 589–91, 597.Google Scholar
211 Weller, SC. A meta-analysis of condom effectiveness in reducing sexually transmitted HIV. Soc Sci Med 1993; 36: 1635–44.CrossRefGoogle ScholarPubMed
212 Stone, KM, Grimes, DA, Magder, LS. Personal protection against sexually transmitted diseases. Am J Obstet Gynecol 1986; 115: 180–88.CrossRefGoogle Scholar
213 Bounds, W, Guillebaud, J, Newman, GB. Female condom (FemidomTM): a clinical study of its use-effectiveness and patient acceptability. Br J Fam Plan 1992; 18: 36–41.Google Scholar
214 Soper, DE, Brockwell, NJ, Dalton, HP. Evaluation of the effects of a female condom on the female lower genital tract. Contraception 1991; 44: 21–29.CrossRefGoogle ScholarPubMed
215 Greenblatt, RM, Lukehart, SL, Plummer, FA et al. Genital ulceration as a risk factor for human immunodeficiency virus infection. AIDS 1988; 2: 47–50.CrossRefGoogle ScholarPubMed
216 Simonsen, JN, Cameron, DW, Gakinya, MN et al. Human immunodeficiency virus infection among men with sexually transmitted diseases. Experience from a center in Africa. N Engl J Med 1988; 319: 274–78.CrossRefGoogle ScholarPubMed
217 Handsfield, HH. Gonorrhea and uncomplicated gonococcal infection. In: Holmes, KK, Mardh, PA, Sparling, PF, Wiesner, PJ eds. Sexually transmitted diseases. New York: McGraw Hill, 1984: 205–17.Google Scholar
218 Hart, G. Factors influencing venereal infection in a war environment. Br J Vener Dis 1974; 50: 68–72.Google Scholar
219 Hooper, RR, Reynolds, GH, Jones, OG et al. Cohort study of venereal disease. I. The risk of gonorrhea transmission from infected women to men. Am J Epidemial 1978; 108: 136–44.CrossRefGoogle ScholarPubMed
220 Belec, L, Georges, AJ, Steenman, G, Martin, PMV. Antibodies to human immunodeficiency virus in vaginal secretions of heterosexual women. J Infect Dis 1989; 160: 385–91.CrossRefGoogle ScholarPubMed
221 Kutteh, WH, Hatch, KD, Blackwell, RE, Mestecky, J. Secretory immune system of the female reproductive tract. I. Immunoglobulin and secretory component containing cells. Obstet Gynecol 1988; 71: 56–60.Google ScholarPubMed
222 Lu, X-S, Belec, L, Pillot, J. Anti-gp 160 IgG and IgA antibodies associated with a large increase in total IgG in cervicovaginal secretions from human immunodeficiency virus type-1-infected women. J Infect Dis 1993; 167: 1189–92.CrossRefGoogle Scholar