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Perspective de la plate-forme NEMOSIS dans lecadre d’une réduction de doses en imagerie

Published online by Cambridge University Press:  09 November 2012

R. Laurent ,
R. Gschwind ,
M. Salomon ,
J. Henriet  and
L. Makovicka
R. Laurent
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
R. Gschwind
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
M. Salomon
Affiliation:
AND/DISC/FEMTO-ST, UMR 6174 CNRS, Université de Franche-Comté, BP 527, 90016 Belfort Cedex, France
J. Henriet
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
L. Makovicka
Affiliation:
IRMA/LCPR-AC/Chrono-Environnement, UMR 6249 CNRS, Université de Franche-Comté, BP 71427, 25211 Montbéliard Cedex, France
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Abstract

L’acquisition du mouvement est de plus en plus souventeffectuée pour améliorer la balistique des traitements en radiothérapieexterne. Cependant, elle est source d’une exposition supplémentairepour le patient. Le développement de la plate-forme de simulationnumérique NEMOSIS (NEural NEtwork MOtion SImulation System)ouvre la voie à l’optimisation de la dose en imagerie. Elle permetde générer un mouvement pulmonaire localisé et personnalisé à partirdu modèle 3D du patient. Pour 3 patients test, 5 à 6 points anatomiquesont été simulés puis comparés aux tracés du radiothérapeute. Dansle cas le plus défavorable, les résultats ont montré une précisionmoyennée sur l’ensemble des points d’un patient et sur toutes lesphases d’environ 3 mm avec une incertitude élargie de tracé égaleà 1,5 mm (intervalle de confiance de 95 %) et une incertitude maximalede phase atteignant 6,53 mm. Une autre étude comparant les GTV (Gross Tumor Volume) d’un radiothérapeute et ceuxcalculés par NEMOSIS a été également menée. Un indice de Dice stipulant unecorrespondance minimale de 0,80 a été calculé entre les deux typesde volumes. Ces résultats font de NEMOSIS un outil très prometteuren tant qu’alternative aux imageries irradiantes.

Keywords

lung motionnumerical simulationdose optimizationimaging
Type
Research Article
Information
Radioprotection , Volume 47 , Issue 4 , October 2012 , pp. 599 - 617
Copyright
© EDP Sciences, 2012

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