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Modélisation de la décorporation du Pu/am par le dtpa

Published online by Cambridge University Press:  09 December 2009

P. Fritsch ,
A.-L. Sérandour ,
O. Grémy ,
B. Le Gall ,
G. Phan ,
N. Tsapis ,
E. Fattal ,
H. Benech ,
J.-R. Deverre  and
N. Blanchin
...Show all authors
P. Fritsch
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, 91680 Bruyères-le-Châtel, France.
A.-L. Sérandour
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, 91680 Bruyères-le-Châtel, France.
O. Grémy
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, 91680 Bruyères-le-Châtel, France.
B. Le Gall
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, 91680 Bruyères-le-Châtel, France.
G. Phan
Affiliation:
CEA/DSV/iBITEC/SPI, 91191 Gif-sur-Yvette, France.
N. Tsapis
Affiliation:
Université Paris-Sud, UMR CNRS 8612, 92296 Châtenay-Malabry, France.
E. Fattal
Affiliation:
Université Paris-Sud, UMR CNRS 8612, 92296 Châtenay-Malabry, France.
H. Benech
Affiliation:
CEA/DSV/iBITEC/SPI, 91191 Gif-sur-Yvette, France.
J.-R. Deverre
Affiliation:
CEA/DSV/i2BM/SHFJ, 91401 Orsay, France.
N. Blanchin
Affiliation:
CEA/SMT Cadarache, 13108 Saint-Paul-lez-Durance, France.
L. Grappin
Affiliation:
CEA/SMT Cadarache, 13108 Saint-Paul-lez-Durance, France.
E. Blanchardon
Affiliation:
IRSN/DRPH/SDI/LEDI, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
B. Breustedt
Affiliation:
FZK/GmbH, PO Box 3640, 76021 Karlsruhe, Allemagne.
J.-L. Poncy
Affiliation:
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, 91680 Bruyères-le-Châtel, France.
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Abstract

Un nouvel outil a été développé pour optimiser l’efficacité des traitements par le DTPA après blessure, sur la base d’une réduction de la dose efficace engagée. Les simulations montrent, notamment, que pour du 239Pu modérément soluble (type M), des traitements précoces (24 i.v.) étalées sur 4 mois permettent une réduction d’un tiers de la dose, alors que leur prolongement sur 5 ans, avec un intervalle de 2 semaines, peut diminuer la dose d’un facteur 5. En revanche, pour des composés peu solubles (type S), l’efficacité des traitements précoces est négligeable et un gain dosimétrique d’un facteur 3 n’est atteint que pour des traitements effectués 2 fois par mois durant 50 ans. Certaines des hypothèses retenues pour la modélisation ont été validées par les résultats d’expérimentations animales récemment publiés. Enfin, la structure d’un nouveau modèle applicable à la fois au Pu et à l’Am est rapportée, structure tenant compte de la décorporation urinaire et fécale de ces actinides et qui pourrait être adapté à différentes posologies et formes galéniques de DTPA.

Keywords

DTPAplutoniumamericiuminhalationwound
Type
Research Article
Information
Radioprotection , Volume 44 , Issue 4 , October 2009 , pp. 431 - 446
Copyright
© EDP Sciences, 2009

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