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Interaction uranium-cellule cible : exemple de la transformation de particules d'UO4 dans le macrophage alvéolaire

Published online by Cambridge University Press:  17 June 2005

M. H. Hengé-Napoli ,
E. Ansoborlo ,
V. Chazel ,
R. Gibert ,
P. Houpert ,
F. Paquet  and
L. Zhang
M. H. Hengé-Napoli
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
E. Ansoborlo
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
V. Chazel
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
R. Gibert
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
P. Houpert
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
F. Paquet
Affiliation:
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
L. Zhang
Affiliation:
CNRS, Université de Paris XI, Laboratoire de Physique des Solides, F-91405 Orsay Cedex
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Abstract

Interactions between uranium and target cells: Example of UO4 particle transformation within alveolar macrophages.Interactions between uranium and target cells: examples of UO4 particle transformation within alveolar macrophages. 
The understanding of the mechanisms involved in the in vivo dissolution of inhaled particles is necessary to improve the model for determining the parameters. With that perspective, theintracellular transformation of UO4 particles has been investigated. Indeed, very few is known about this compound encountered in the nuclear fuel cycle. After instillation of UO4 particles in rats,alveolar macrophages and lung tissues have been observed. The particles break up very quickly in ultrafine particles and in some cases, this mechanism is accompanied by the formation of uranylphosphate needles. This phenomenon takes place at very early stage, i.e., within the first 24 hours after the instillation. Particles phagocytised by macrophages in vitro have been observed afterinclusion of the cells directly on the culture dish. These observations have confirmed the corrosive action exerted by the macrophages on the UO4 particles.

Keywords

uranium oxidebiological effectslungs, rodent
Type
Research Article
Information
Radioprotection , Volume 32 , Issue 5 , December 1997 , pp. 625 - 636
Copyright
© EDP Sciences, 1997

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