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CEA-EXPO: A facility exposure matrixto assess passed exposure to chemical carcinogens and radionuclides of nuclear workers

Published online by Cambridge University Press:  17 June 2005

M. Telle-Lamberton ,
P. Bouville ,
D. Bergot ,
M. Gagneau ,
S. Marot ,
J. M. Giraud  and
J. M. Gelas
M. Telle-Lamberton
Affiliation:
IRSN/DRPH/SRBE/LEPID, B.P. 17, 92262 Fontenay-aux-Roses Cedex, France Present address: Institut de Veille Sanitaire, Département Santé Travail, 12 rue du Val d’Osne, 94415 St Maurice Cedex, France
P. Bouville
Affiliation:
IRSN/DRPH/SRBE/LEPID, B.P. 17, 92262 Fontenay-aux-Roses Cedex, France
D. Bergot
Affiliation:
IRSN/DRPH/SRBE/LEPID, B.P. 17, 92262 Fontenay-aux-Roses Cedex, France
M. Gagneau
Affiliation:
IRSN/DRPH/SRBE/LEPID, B.P. 17, 92262 Fontenay-aux-Roses Cedex, France
S. Marot
Affiliation:
IRSN/DRPH/SRBE/LEPID, B.P. 17, 92262 Fontenay-aux-Roses Cedex, France
J. M. Giraud
Affiliation:
CEA, 31-33 rue de la Fédération, 75752 Paris Cedex 15, France
J. M. Gelas
Affiliation:
COGEMA, 2 rue Paul Dautier, B.P. 4, 78141 Vélizy-Villacoublay Cedex, France
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Abstract

A “Facility-Exposure Matrix” (FEM) is proposed to assess exposure to chemical carcinogens and radionuclides in a cohort of nuclear workers. Exposures are to be attributed in the following way: a worker reports to an administrative unit and/or is monitored for exposure to ionising radiation in a specific workplace. These units are connected with a list of facilities for which exposure is assessed through a group of experts. The entire process of the FEM applied in one of the nuclear centres included in the study shows that the FEM is feasible: exposure durations as well as groups of correlated exposures are presented but have to be considered as possible rather than positive exposures. Considering the number of facilities to assess (330), ways to simplify the method are proposed: (i) the list of exposures will be restricted to 18 chemical products retained from an extensive bibliography study; (ii) for each of the following classes of facilities: nuclear reactors, fuel fabrication, high-activity laboratories and radiation chemistry, accelerators and irradiators, waste treatment, biology, reprocessing, fusion, occupational exposure will be deduced from the information already gathered by the initial method. Besides taking into account confusion factors in the low doses epidemiological study of nuclear workers, the matrix should help in the assessment of internal contamination and chemical exposures in the nuclear industry.

Keywords

job exposure matrixchemical exposurenuclear workersepidemiology
Type
Other
Information
Radioprotection , Volume 40 , Issue 2 , April 2005 , pp. 173 - 189
Copyright
© EDP Sciences, 2005

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References

Ahrens, W., Jockel, K.H., Brochard, P., Bolm-Audorff, U., Grossgarten, K., Iwatsubo, Y., Orlowski, E., Pohlabeln, H., Berrino, F. (1993) Retrospective assessment of asbestos exposure – I. Case-control analysis in a study of lung cancer: efficiency of job-specific questionnaires and job exposure matrices, Int. J. Epidemiol. 22, S83–S95. CrossRef
Baysson, H., Laurier, D., Tirmarche, M., Valenty, M., Giraud, J.M. (2000) Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards, Occup. Environ. Med. 57, 188-194. CrossRef
Beral, V., Fraser, P., Carpenter, L., Booth, M., Brown, A., Rose, G. (1988) Mortality of employees of the Atomic Weapons Establishment, 1951-82, Br. Med. J. 297, 757-770. CrossRef
Bouyer, J., Hemon, D. (1993) Comparison of three methods of estimating odds ratios from a job exposure matrix in occupational case-control studies, Am. J. Epidemiol. 137, 472-481. CrossRef
Bouyer, J., Hemon, D. (1994) Job exposure matrices, Rev. Epidemiol. Sant. Publ. 42, 235-245.
Burstyn, I. (2004) Principal Component Analysis is a powerful instrument in occupational hygiene inquiries, Ann. Occup. Hyg. 48, 655-661.
Cardis, E., Gilbert, E.S., Carpenter, L., Howe, G., Kato, I., Armstrong, B.K., Beral, V., Cowper, G., Douglas, A., Fix, J., et al. (1995) Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries, Radiat. Res. 142, 117-132. CrossRef
Carpenter, L., Higgins, C., Douglas, A., Fraser, P., Beral, V., Smith, P. (1994) Combined analysis of mortality in three United Kingdom nuclear industry workforces, 1946-1988, Radiat. Res. 138, 224-238. CrossRef
Goldberg, M., Kromhout, H., Guenel, P., Fletcher, A.C., Gerin, M., Glass, D.C., Heederik, D., Kauppinen, T., Ponti, A. (1993) Job exposure matrices in industry, Int. J. Epidemiol. 22, S10-S15. CrossRef
Gribbin, M.A., Weeks, J.L., Howe, G.R. (1993) Cancer mortality (1956-1985) among male employees of Atomic Energy of Canada Limited with respect to occupational exposure to external low- linear-energy-transfer ionizing radiation, Radiat. Res. 133, 375-380. CrossRef
Guenel, P., Nicolau, J., Imbernon, E., Warret, G., Goldberg, M. (1993) Design of a job exposure matrix on electric and magnetic fields: selection of an efficient job classification for workers in thermoelectric power production plants, Int. J. Epidemiol. 22, S16-S21. CrossRef
Heineman, E.F., Cocco, P., Gomez, M.R., Dosemeci, M., Stewart, P.A., Hayes, R.B., Zahm, S.H., Thomas, T.L., Blair, A. (1994) Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer, Am. J. Ind. Med. 26, 155-169. CrossRef
IARC (1998) IARC monographs on the evaluation of carcinogenic riks to humans, List of IARC evaluations.
Imbernon, E., Goldberg, M., Bonenfant, S., Chevalier, A., Guenel, P., Vatre, R., Dehaye, J. (1995) Occupational respiratory cancer and exposure to asbestos: a case- control study in a cohort of workers in the electricity and gas industry, Am. J. Ind. Med. 28, 339-352. CrossRef
Iwasaki, T., Murata, M., Ohshima, S. (2003) Second analysis of mortality of nuclear industry workers in Japan, 1986-1997, Radiat. Res. 159, 228-38. CrossRef
Jéjati, H., Laurier, D., Tirmarche, M., Valenty, M., Giraud, J. (1998) Étude de cohorte en milieu professionnel: utilisation des fiches de nuisances et de la mémoire collective afin de reconstituer des expositions multiples., Rev. Méd. Trav. 25, 51.
Kauppinen, T., Partanen, T. (1988) Use of plant- and period-specific job-exposure matrices in studies on occupational cancer, Scand. J. Work. Environ. Health 14, 161-167. CrossRef
Kelsh, M.A., Kheifets, L., Smith, R. (2000) The impact of work environment, utility, and sampling design on occupational magnetic field exposure summaries, Am. Industr. Hyg. Ass. J. 61, 174-182.
Moulin, J.J., Romazini, S., Lasfargues, G., Peltier, A., Bozec, C., Deguerry, P., Pellet, F., Wild, P., Perdrix, A. (1997) Development of a job-exposure matrix in the heavy-metal industry in France, Rev. Epidemiol. Sant. Publ. 45, 41-51.
Muirhead, C.R., Goodill, A.A., Haylock, R.G., Vokes, J., Little, M.P., Jackson, D.A., O'Hagan, J.A., Thomas, J.M., Kendall, G.M., Silk, T.J., Bingham, D., Berridge, G.L. (1999) Occupational radiation exposure and mortality: second analysis of the National Registry for Radiation Workers, J. Radiol. Prot. 19, 3-26. CrossRef
Omar, R.Z., Barber, J.A., Smith, P.G. (1999) Cancer mortality and morbidity among plutonium workers at the Sellafield plant of British Nuclear Fuels, Br. J. Cancer. 79, 1288-1301. CrossRef
Orlowski, E., Pohlabeln, H., Berrino, F., Ahrens, W., Bolm-Audorff, U., Grossgarten, K., Iwatsubo, Y., Jockel, K.H., Brochard, P. (1993) Retrospective assessment of asbestos exposure – II. At the job level: complementarity of job-specific questionnaire and job exposure matrices, Int. J. Epidemiol. 22, S96-S105. CrossRef
Ritz, B. (1999) Radiation exposure and cancer mortality in uranium processing workers, Epidemiology 10, 531-538. CrossRef
Ritz, B., Morgenstern, H., Froines, J., Young, B.B. (1999) Effects of exposure to external ionizing radiation on cancer mortality in nuclear workers monitored for radiation at Rocketdyne/Atomics International, Am. J. Ind. Med. 35, 21-31. 3.0.CO;2-X>CrossRef
Ruttenber, A.J., McCrea, J.S., Wade, T.D., Schonbeck, M.F., LaMontagne, A.D., Van Dyke, M.V., Martyny, J.W. (2001) Integrating workplace exposure databases for occupational medicine services and epidemiologic studies at a former nuclear weapons facility, Appl. Occup. Environ. Hyg. 16, 192-200. CrossRef
Saporta G. (1990) Probabilités, analyse des données et statistique. Paris, Éditions Technip.
Stengel, B., Pisani, P., Limasset, J.C., Bouyer, J., Berrino, F., Hemon, D. (1993) Retrospective evaluation of occupational exposure to organic solvents: questionnaire and job exposure matrix, Int. J. Epidemiol. 22, S72-S82. CrossRef
Straus A. (1996) Pré-étude concernant l’INB 57 (communication personnelle).
Telle M.A., Bergot D., Bard D. (1996) Effects of protracted exposures to low doses of ionising radiations: reconstructing exposures of the French Atomic Energy Commission (CEA) workforce, 9th International Congress on Radiation Protection, 14-16 May 1996, Vienne.
Telle-Lamberton M., Samson E., Caër S., Bergot D., Bard D., Bermann F., Gélas J.M., Giraud J.M., Hill C., Hubert P., Néron M.O., Quesne B., Tirmarche M. (2004) External radiation exposure and cancer mortality among French CEA and COGEMA workers. EPICOH – Seventeenth Symposium on Epidemiology in Occupational Health. Melbourne, Australia, October, Occup. Environ. Med. 61, e18.
Wiggs, L.D., Cox-DeVore, C.A., Wilkinson, G.S., Reyes, M. (1991) Mortality among workers exposed to external ionizing radiation at a nuclear facility in Ohio, J. Occup. Med. 33, 632-637.
Zablotska, L.B., Ashmore, J.P., Howe, G.R. (2004) Analysis of mortality among Canadian nuclear power industry workers after chronic low-dose exposure to ionizing radiation, Radiat. Res. 161, 633-641. CrossRef