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Mieux connaître le devenir biologiquedes futurs matériaux nucléaires,une nécessité pour maintenirun bon niveau de radioprotection

Published online by Cambridge University Press:  19 September 2007

H. Métivier
Affiliation:
2 allée des Hautes Futaies, 91450 Soisy-sur-Seine, France
R. Guillaumont
Affiliation:
Membre de l'Académie des sciences, 7 rue E. Branly, 91120 Palaiseau, France
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Abstract

Un important programme de recherches, appelé « Generation IV », est actuellement développé au niveau international pour préparer les réacteurs du futur et leurs « cycle de combustible ». Son objectif est de satisfaire les besoins croissants en énergie électrique dans le cadre d'un développement durable. L'un des aspects majeurs de ce programme est la recherche et le développement de nouveaux matériaux nucléaires fissiles/fertiles. Malheureusement, on s'aperçoit aujourd'hui que, pour de nombreux composés candidats pour développer ces matériaux, il n'existe pas de données radiotoxicologiques permettant au médecin du travail d'évaluer le risque réel en cas de contamination et de prescrire un traitement de décontamination adapté. Il conviendrait donc de relancer d'urgence les études de poste où sont, ou bien seront, mis en œuvre ces composés ou matériaux. L'expérience passée a montré que la prévision en matière de radioprotection était difficile et qu'une validation expérimentale du comportement des éléments lourds radiotoxiques ou toxiques in vitro et in vivo était nécessaire.

Type
Research Article
Copyright
© EDP Sciences, 2007

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References

Allen, M.D., Briant, J.K., Moss, O.R., Rossignol, E.J., Malhum, D.D., Morgan, L.G., Ryan, J.L., Turcotte, R.P. (1981) Dissolution characteristics of LMFBR fuel-sodium aerosols, Health Phys. 40, 183-193. CrossRef
André, S., Métivier, H., Lantenois, G., Boyer, M., Nolibé, D., Masse, R. (1987) Beryllium metal solubility in the lung, comparison of metal and hot-pressed forms by in-vivo and in vitro dissolution bioassays, Human Toxicol. 6, 233-240. CrossRef
André, S., Métivier, H., Auget, D., Lantenois, G., Boyer, M., Masse, R. (1989a) Lung dissolution of uranium tetrafluoride in rats and baboons. Comparison with dissolution by alveolar macrophages in culture and chemical dissolution, Human Toxicol. 8, 11-119. CrossRef
André, S., Métivier, H., Auget, D., Lantenois, G., Boyer, M., Masse, R. (1989b) Assesment of uranium tetrafluoride dissolution in the lung by in vivo and in vitro methods, Rad. Prot. Dosim. 26, 75-81. CrossRef
Ansoborlo, E., Claraz, M., Hengé-Napoli, M.H., Métivier, H., Garden, J., Cheynet, M.C. (1995) Etude de l'exposition industrielle à des aérosols d'uranium dans le procédé d'enrichissement par Laser - Méthodes et Résultats, Radioprotection 30, 13-24. CrossRef
Ansoborlo, E., Chazel, V., Hengé-Napoli, M.H., Pihet, P. Rannou, A., Bailey, M.R., Stradling, N. (2002) Determination of the physical and chemical properties, biokinetics, and dose coefficients of uranium compounds handled huclear fuel fabrication in France, Health Phys. 82, 279-289. CrossRef
Bailey, M.R., Kreyling, W.G., André, S., Batchelor, A., Collier, C.G., Drosselmeyer, E., Ferron, G.A., Foster, P., Haider, B., Hodgson, A., Masse, R., Métivier, H., Morgan, A., Müller, H.L., Patrick, G., Pearman, I., Pickering, S., Ramsden, D., Strirling, C., Talbot, R.J. (1989) An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles part I: objectives and summary results, J. Aerosol Sci. 20, 169-188. CrossRef
Bair W.J., Park J.F. (1968) Comparative deposition of four types of plutonium dioxides inhaled bu dogs, In Proceedings of the 1st international congress of radiation protection, Rome, September 5-10, 1966. Pergamon Press, Oxford–New-York.
Bair, W.J., Métivier, H., Park, J.F. (1980) Comparison of early mortality in baboons and dogs after inhalation of 239PuO2, Radiat. Res. 82, 588-610. CrossRef
Bair, W.J., Park, J.F., Dagle, G.E., James, A.C. (1989) Overview of biological consequences of exposure to plutonium and higher actinides, Rad. Prot. Dosim. 26, 125-135. CrossRef
Breitenstein B.D., Durbin P.W., Goans R.E., Guilmette R., Russell J.J., Toohey R.E. (2007) The NCRP Radionuclide Dosimetry Models for Wounds, NCRP report, à paraître.
Carter, M.W. (1995) Is measurement of transportability class of inhaled material by in vitro dissolution satisfactory? Health Phys. 69, 549-552. CrossRef
CEA (2005) L'Energie nucléaire du futur: quelles recherches pour quels objectifs? Commissariat à l'énergie atomique, e-den, une monographie de la Direction de l'énergie nucléaire. CEA Saclay et Groupe Moniteur, Paris, ISBN 2-281-11307-8.
Chazel, V., Houpert, P., Ansoborlo, E. (1998) Effect of U3O8 specific surface area on in vitro dissolution, biokinetics, and dose coefficients, Rad. Prot. Dosim. 79, 39-42. CrossRef
Cooke, N., Holt, F.B. (1974) The solubility of some uranium compounds in simulated lung fluid, Health Phys. 27, 69-77. CrossRef
Diamond, G.L. (1989) Biological consequences of exposure to soluble forms of uranium, Radiat. Prot. Dosim. 26, 23-33. CrossRef
Dilley J.V. (1970) Effect of DTPA on inhaled 239PuF4 in beagles, Pacific Northwest Laboratory annual report for 1968 to the USAEC Division of biology and medicine, BNWL-1050, vol 1, part 1, p5.14-5.17.
Durbin, P. (1960) Metabolic characteristics within a chemical family, Health Phys. 2, 225-238. CrossRef
Durbin P. (1973) Metabolism and biological effects of the transplutonium elements, In Uranium, Plutonium Transplutonic Elements, H.C.Hodge, J.N.Stannard, J.B.Hursh (Eds). Springer-Verlag, Berlin, pp. 739-896.
Durbin (2006) Actinides in animals and man, 3339-3440.
Eidson A.F. (1994) The effect of solubility on inhaled uranium compound and clearance; a review, Health Phys. 45, 1023-1037.
Eidson, A.F., Mewhinney, J.A. (1983) In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuelss, Health Phys. 45, 1023-1037. CrossRef
Fleischer, R.L. (1975) On the "dissolution" of respirable PuO2 particles, Health Phys. 29, 69-73. CrossRef
Fleischer, R.L., Raabe, O.G. (1977) Fragmentation of respirable PuO2 in water by alpha decay - A mode of dissolution, Health Phys. 32, 253-257. CrossRef
Fleischer, R.L., Raabe, O.G. (1978) On the mechanisms of "dissolution" in liquids of PuO2 by alpha decay, Health Phys. 35, 545-548. CrossRef
Gamble J.L. (1967) Chemical anatomy, Physiology and pathology of extracellular fluid, 8th edn. Harvard University Press, pp. 4-11.
GLOBAL (2003) Proceedings of GLOBAL 2003, Atoms for Prosperity: Updating Eisenhower's Global Vision for Nuclear Energy, New Orleans, Louisiana, November 16-20, 2003. ISBN 0-89448-677-2
GLOBAL (2005) International conference GLOBAL 2005, Nuclear Energy Systems for future generation adn global sustainability, Tsukuba, Japan, October 9-13, 2005.
Guilmette, R.A., Griffith, W.C., Hickman, A.W. (1989) Intake assessment for workers who have inhaled 238Pu aerosols, Rad. Prot. Dosim. 53, 127-131. CrossRef
Hamilton J.G. (1948) Medical and Health Physics Quaterly Report, UCRL-41, University of Califonia, Radiation Laboratory, p. 15.
Hengé-Napoli, M.H., Ansoborlo, E., Donnadieu-Claraz, Berry J.P., Gibert R., Pradal B. (1994) Solubility and transferability of several industrial forms of uranium oxides, Rad. Prot. Dosim. 53, 157-161. CrossRef
ICRP Publication 66 (1994a) Human respiratory tract model for radiological protection, Ann. ICRP 24(1-3).
ICRP Publication 67 (1994b) Age-dependent doses to members of the public from intake of radionuclides: Part 2 Ingestion dose coefficients, Ann. ICRP 23(3/4).
ICRP Publication 68 (1995a) Dose coefficients for intakes of radionuclides by workers, Ann. ICRP 24(4).
ICRP Publication 69 (1995b) Age-dependent doses to members of the public from intake of radionuclides: Part 3 Ingestion dose coefficients, Ann. ICRP 25(1).
ICRP Publication 100 (2007) Human alimentary tract model for radiological protection, Ann. ICRP 36(1-2).
Kanapilly, G.M., Raabe, O.G., Goh, C.H.T., Chimenti, R.H. (1973) Measurement of in vitro dissolution of aerosol particles by comparisons to in vivo dissolution in the lower respiratory tract after inhalation. Health Phys. 24, 497-507. CrossRef
Lanz H., Scott K.G., Crowley J., Hamilton J.G. (1946) The metabolism of Thorium, Protactinium and Neptunim in the rat, USAEC MDDC-648 (CH-3606)
Lataillade, G., Verry, M., Rateau, G., Métivier, H., Masse, R. (1995) translocation of plutonium from rat and monkey lung after inhalation of industrial plutonium oxide and mixed uranium and plutonium oxide, Int. J. Radiat Biol. 67, 3,373-380. CrossRef
Lirsac, P.N., Nolibé, D., Métivier, H. (1989) Immobilization of alveolar macrophages for measurement of in vitro dissolution of aerosols particles, Int. J. Radiat. Biol. 56, 1011-1021. CrossRef
Mc Donald, K.E., Dilley, J.V., Sanders, C.L., Mahaffey, J.A. (1979) The influence of DTPA on the metabolism of inhaled 239PuF4 in Beagles, Health Phys. 36, 632-635
Masse, R., Métivier, H. (1990) Intérêt du primate pour l'évaluation de la pathologie pulmonaire, Pathol. Biol. 8, 193-196.
Masse R., Métivier H., Guillaumont R. (1973) Fixation osseuse des terres rares et des éléments transuraniens. Colloques Internationaux CNRS N° 30, « Physico-chimie et cristallographie des apatites d'intérêt biologique », 10-15 septembre 1973, pp. 441-450.
Métivier, H. (1976) Devenir biologique des mélanges d'aérosols d'oxyde de sodium et de plutonium, Radioprotection 11, 271-278 CrossRef
Métivier, H. (1979) Devenir biologique des transuraniens inhalés, Radioprotection 14, 19-39. CrossRef
Métivier, H. (1989) Physico-chimie et devenir biologique des radioéléments de l'industrie nucléaire, Revue Générale Nucléaire 4, 314-317. CrossRef
Métivier, H., Masse, R. (1986) Données nouvelles sur la biologie des actinides - Conséquences en matière de radioprotection, Journal of the Less Common Metals 122, 475-485. CrossRef
Métivier H., Masse R., Nénot J.C., Nolibé D., Lafuma J. (1976) Etude expérimentale de la contamination par un mélange issu de la combustion du sodium en présence d'oxyde de plutonium, IAEA-SR-6/37, pp. 107-117.
Métivier, H et al. (1980) Experimental study of respiratory contamination by a mixed oxide aerosols formed from the combustion of a plutonium magnesium alloy, Health Phys. 38, 769-776. CrossRef
Métivier, H., Masse, R., Lafuma, J. (1983) Metabolism of plutonium introduced as tri-n-butylphosphate complex in the rat and removal attempts by DTPA, Health Phys. 44, 623-634. CrossRef
Métivier, H., Piechowski, J., Duserre, C., Rateau, G., Legendre, N., Menoux, B., Masse, R. (1989) Biological behaviour of plutonium inhaled by baboons as plutonium n-tributylphosphate complex. Comparison with ICRP models, Rad. Prot. Dosim. 26, 287-291. CrossRef
Mewhinney J.A., Muggenburg B.A., McClellan R.O., Miglio J.J. (1976) The effect of varying physical and chemical characteristics of inhaled plutonium aerosols on metabolism and excretion, In Diagnosis and Treatment of Incorporated Radionuclides, IAEA, Vienna, pp. 87-97.
Morgan, A., Black, A., Knight, D., Moores, S.R. (1988) The effect of firing temperature on the lung retention and translocation of Pu following the inhalation of 238PuO2 and 239PuO2 by CBA/H mice, Health Phys. 54, 301-310. CrossRef
Moody, J.C., Stradling, G.N., Britcher, A.R. (1994) Biokinetics of the industrial plutonium nitrate materials: implications for human exposure, Rad. Prot. Dosim. 53, 169-172. CrossRef
Neck, V., Altmeier, M., Müller, R., Bauer, A., Fanghanel, T., Kim, J.I. (2003) Solubility of cristallin thorium dioxide, Radiochim. Acta 91, 253-262. CrossRef
Nolibé, D., Duserre, C., Gil, I., Rateau, G., Métivier, H. (1989) Biological behaviour of plutonium given as a trilaurylamine complex. Comparison with plutonium-tributylphosphate, Rad. Prot. Dosim. 26, 303-306. CrossRef
OCDE (2004) NEA N° 5427, Pyrochemical separations in nuclear applications, A status report.
OCDE (2005) NEA N° 5419, Fuels and materials for transmutation, A status report.
OCDE (2006) NEA N° 6051, Besoins de recherche et développement pour les systèmes nucléaires actuels et futurs.
Ogawa T., Crawford D., Konings R.J.M., S. Pillon S., Schram R.P.C., Verwerft M., J. Wallenius J. (2005) State-of-art technology of fuels for burning minor actinides, An OECD/NEA study, Proceeding of Global 2005, Tsukuba, Japan, Oct. 9-13, Paper n° 316.
Pillon S. (2004) ouvrage collectif dirigé par S. Pillon, Synthèse sur les combustibles et cibles de transmutation, CEA/DEN/CAD/DEC/DIR04/002.
Poncy, J.L., Métivier, H., Dhilly, M., Verry, M., Masse, R. (1992) In vitro dissolution of uranium oxide by baboon alveolar macrophages, Env. Health Persp. 97, 127-130. CrossRef
Ralston L.G., Cohen N., Bjattacharyya M.H., Larsen R.P., Ayres L., Oldham R.D., Moretti E.S. (1986) The metabolism and gastrointestinal absorption of neptunium and protactinium in adult baboons, in Speciation of fission and activation products in the environment, R.A. Bulman, J.R. Cooper (Eds). Elsevier, Oxford, p. 191.
Ramounet, B., Rateau, G., Abram, M.C., Grillon, G., Ansoborlo, E., Bérard, P., Delforge, J., Fritsch, P. (2003) In vivo measurement of Pu dissolution parameters of MOX aerosols and related uncertainties in the values of the dose per unit of intake, Rad. Prot. Dosim. 105, 153-156. CrossRef
Rhoads, K., Killand, B.W., Mahaffey, J.A., Sanders, C.L. (1986) Lung clearance and translocation of 239Pu and 244Cm in rats following inhalation individually or as a mixed oxide, Health Phys. 51, 633-640. CrossRef
Sanders, C.L. (1972) Deposition patterns and the toxicity of transuranium elemenbts in lung, Health Phys. 22, 607-615. CrossRef
Sato, H., Yamada, Y., Ishigure, N., Nakano, T., Enomoto, H., Takahashi, S., Kubota, Y., Inaba, J. (1999) Retention, Excretion and Translocation of 239Pu in rats following inhalation of 239Pu02 calcined at 1150 and 400°C., J. Rad. Res. 40, 197-204. CrossRef
Stradling, G.N., Loveless, B.W., Ham, G.J., Smith, H. (1978) the biological solubility in the rat of plutonium present in mixed plutonium-sodium aerosols, Health Phys. 35, 229-235. CrossRef
Stradling, G.N., Stather, J.W., Gray, S.A., Moody, J.C., Bailey, M.R., Hodgson, A., Collier, C. (1987) Studies on the metabolic behaviour of industrial actinide-bearing aerosols after deposition in the rat lung: An experimental basis for interpretating chest monitoring data and assessing limits on intake for workers, Human Toxicology 6, 365-375. CrossRef
Thompson R.C. (1989) Life-span effects of ionizing radiation in the beagle dog, Pacific Northwest National Laboratory, Richland, WA 9352, pp. 31-57.
USDOE (2006) Report on basic reasearch needs for advanced nuclear energy systems, Office of basic energy sciences, USDOE, October 2006.