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The structure of serum lipoproteins as analysed by X-ray small-angle scattering

Published online by Cambridge University Press:  17 March 2009

Peter laggner  and
Karl W. MÜller
Peter laggner
Affiliation:
Institut für Rontgenfeinstrukturforschung der Österreichischen Akademie der Wissenschaften und des Forschungszentrums Graz, Steyrergasse 17, Graz, Austria
Karl W. MÜller
Affiliation:
Institut für Rontgenfeinstrukturforschung der Österreichischen Akademie der Wissenschaften und des Forschungszentrums Graz, Steyrergasse 17, Graz, Austria
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Extract

Serum lipoproteins are the macromolecular lipid–protein complexes, soluble in aqueous environment, which act as transport vehicles for polar and apolar lipids in the bloodstream. The growing multidisciplinary interest in these systems stems on the one hand from the fact that their physiological functions are intimately related to the pathways of lipid metabolism and catabolism, and on the other hand from their macromolecular nature which renders them accessible to a large variety of experimental approaches for the study of the physical and chemical principles of lipid-protein interaction.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 11 , Issue 3 , August 1978 , pp. 371 - 425
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Alaupovic, P. (1972). Classification system of plasma lipoproteins. In Protides of the Biological Fluids (ed. Peeters, H.), pp. 9–19. Oxford: Pergamon Press.CrossRefGoogle Scholar
Anderson, D. W., Nichols, A. V., Pan, S. S. & Lindgren, F. T. (1977). Particle distribution of human serum high density lipoproteins. Biochim. biophys. Acta 493, 55–68.CrossRefGoogle ScholarPubMed
Assmann, G. & Brewer, H. B. (1974). A molecular model of high density lipoproteins. Proc. natn. Acad. Sci. U.S.A. 71, 1534–1538.CrossRefGoogle ScholarPubMed
Atkinson, D., Davis, M. A. F. & Leslie, R. B. (1974) The structure of high density lipoprotein (HDL3) from porcine plasma. Proc. R. Soc. Lond. B 186, 165–180.Google ScholarPubMed
Atkinson, D., Smith, H. M., Dickson, J. & Austin, J. P. (1976). Interaction of apoprotein from porcine high-density lipoprotein with dimyristoyllecithin. I. The structure of the complexes. Eur. J. Biochem. 64, 541–547.CrossRefGoogle Scholar
Atkinson, D., Deckelbaum, R. J., Small, D. M. & Shipley, G. G. (1977). Structure of human plasma low-density lipoproteins: molecular organization of the central core. Proc. natn. Acad. Sd. U.S.A. 74, 1042–1046.CrossRefGoogle ScholarPubMed
Camejo, G., Colaccico, G. & Rapport, M. M. (1968). Lipid monolayers: Interactions with the apoprotein of high density plasma lipoprotein. J. Lipid Res. 9, 562–569.CrossRefGoogle ScholarPubMed
Craven, B. M. & De, Tirra G. T. (1976). Cholesteryl myristate: structure of the crystalline and mesophases. J. Chem. Soc. Perkin Trans. 27, 814–822.CrossRefGoogle Scholar
Debye, P. (1915). Zerstreuung von Rontgenstrahlen. Ann. Physik 46, 809–823.CrossRefGoogle Scholar
Deckelbaum, R. J., Shipley, G. G., Small, D. M., Lees, R. S. & George, P. K. (1975). Thermal transitions in human plasma LDL. Science, N. Y. 190, 392–394.CrossRefGoogle Scholar
Deckelbaum, R. J., Shipley, G. G. & Small, D. M. (1977). Structure and interactions of lipids in human plasma low density lipoproteins. J. biol. Chem. 252, 744–754.CrossRefGoogle ScholarPubMed
Fisher, W. R., Hammond, M. G. & Warmke, G. L. (1972). Measurements of the molecular weight variability of plasma low density lipoproteins among normals and subjects with hyper-β-lipoproteinemia. Demonstration of macromolecular heterogeneity. Biochemistry, N. Y. II, 519–525.CrossRefGoogle Scholar
Forte, T. M., Nichols, A. V., Gong, E. L., Lux, S. & Levy, R. I. (1971). Electron microscopy on reassembly of plasma high-density apoprotein with various lipids. Biochim. biophys. Acta 248, 381–386.Google Scholar
Forte, T. & Nichols, A. V. (1972). Application of electron microscopy to the study of plasma lipoprotein structure. Adv. Lipid Res. 10, 1–41.Google Scholar
Glatter, O. (1977 a). A method for the evaluation of small-angle scattering data. J. app1. Crystallogr. 10, 415–421.CrossRefGoogle Scholar
Glatter, O. (1977 b). Data evaluation in small angle scattering: calculation of the radial electron density distribution by means of indirect Fourier transformation. Acta phys. austriaca 47, 83–102.Google Scholar
Glatter, O. (1978). Interpretation of real space information from small- angle scattering experiment. J. appi. Crystallogr. (in the Press).Google Scholar
Greville, T. N. E. (1969). In Theory and Applications of Spline Functions. New York: Academic Press.Google Scholar
Guinier, A. & Fournet, G. (1955). In Small Angle Scattering of X-rays. New York, London: John Wiley & Sons.Google Scholar
Hamilton, R. L., Havel, R. J., Kane, J. P., Blaurock, A. E. & Sata, T. (1971). Cholestasis: lamellar structure of the abnormal human serum lipoprotein. Science, N.Y. 172, 475–478.Google Scholar
Hey, M. J., Clough, J. M. & Taylor, D. J. (1976). Ion effects on macromolecules in aqueous solution. Nature. Lond. 262, 807–809.Google Scholar
Jackson, R. L., Bajer, H. N., Taunon, O. D., Smith, L. C., Garner, C. W. & Gotto, A. M., JR. (1973). A comparison of the major apolipoprotein from pig and human high density lipoproteins. J. biol. Chem. 248, 2639–2644.Google Scholar
Jackson, R. L., Morrisett, J. D. & Gorro, A. M., JR. (1976). Lipoprotein structure and metabolism. Physiol. Rev. 56, 259–316.Google Scholar
Kostner, G. & Alaupovic, P. (1972). Studies of the composition and structure of plasma lipoproteins. Separation and quantification of the lipoprotein families occurring in the high density lipoproteins of human plasma. Biochemistry, N.Y. II, 3419–3428.CrossRefGoogle Scholar
Kostner, G. M. & Holasek, A.The separation of human serum high density lipoproteins by hydroxyapitite colunm chromatography. Evidence for the presence of discrete subfractions. Biochim. biophys. Acta 488, 417–431.CrossRefGoogle Scholar
Kratky, .O (1958). Neues Verfahren zur Herstellung von blendungsstreuungsfreien Rontgenkleinwinkelaufnahmen. IV. Z. Elektrochem. 62, 66–73.Google Scholar
Kratky, O. (1963). X-ray small angle scattering with substances of biological interest in diluted solutions. Frog. Biophys. biophys. Chem. 13, 105–173.Google ScholarPubMed
Kratky, O. & Pilz, I. (1972). Recent advances and applications of diffuse X-ray small-angle scattering on biopolymers in dilute solutions. Qt. Rev. Biophys. 5, 485–537.Google Scholar
Kratky, O.Leopold, H. & Stabinger, H. (1973). The determination of the partial specific volume of proteins by the mechanical oscillator technique, in Methods in Enzymology 27, part D (ed. Hirs, C. W. H. and Timasheff, S. N.), pp. 98–110. New York, London: Academic Press.Google Scholar
Laggner, P., Kratky, O., Kostner, G., Sattler, J. & Holasek, A. (1972).Small angle X-ray scattering of LpA, the major lipoprotein family ofhuman plasma high density lipoprotein HDL3,. FEBS Lett. 27, 53–57.CrossRefGoogle Scholar
Laggner, P., Mülle, K., Kratky, O., Kostner, G. & Holasee, A. (1973). Studies on the structure of lipoprotein A of human high density lipoproteins HDL3: the spherically averaged electron density distribution. FEBS Lett. 33, 77–80.CrossRefGoogle ScholarPubMed
Laggner, P., Muller, K., Kratky, O., Kostner, G. & Holasek, A. (1976).X-ray small angle scattering on human plasma lipoproteins. J. Colloid Interface Sci. 55, 102–108.Google Scholar
Laggner, P. (1976). Physicochemical characterization of low density lipoproteins. In Low Density Lzoproteins (ed. Day, C. E. and Levy, R. S.), pp. 49–69. New York: Plenum Publishing Corporation.Google Scholar
Laggner, P., Degovics, G., Müller, K. W., Glatter, O., Kratky, O., Kostner, G. & Holasek, A. (1977 a). Molecular packing and fluidity of lipids in human serum low density lipoproteins. Hoppe Seyler's Z. Fhysiol. Chem. 358, 771–778.CrossRefGoogle ScholarPubMed
Laggner, P., Glatter, O, Müller, K., Kratky, O., Kostner, C. & Holasek, A. (1977 b). The lipid bilayer structure of the abnormal human plasma lipoprotein X: an X-ray small-angle scattering study. Eur. J. Biochem. 77, 165–171.CrossRefGoogle ScholarPubMed
Laggner, P. (1978 a). Structural principles in plasma lipoproteins. X-ray small angle scattering studies. In Protides of Biological Fluids. 25th Colloquium 1977 (ed. Peeters, H.), pp. 59–66. Oxford: Pergamon Press.Google Scholar
Laggner, P. (1978 b). Physicochemical characterization of high density lipoproteins. In High Density Lzpoproteins (ed. Day, C. and Levy, R. I.). New York: Plenum Press (in the Press).Google Scholar
Laggner, P., Goldstein, S. & Chapman, M. J. (1978). X-ray small angle scattering study on the structure of partially trypsin-digested human plasma low-density lipoprotein. Biochein. biophys. Res. Commun.(in the Press).Google Scholar
Laggner, P., Gotto, A. M. JR & Moiuuserr, J. D. (1978). Structure of dimyristoylphophatidylcholine vesicles and of the complex formed by their interaction with apolipoprotein C-Ill: X-ray small angle scattering studies. Submitted to Biochemistry, N.Y.Google Scholar
Lee, D. M. & Alaupovic, P. (1974). Physicochemical properties of low-density lipoproteins of normal human plasma. Evidence for the occurrence of lipoprotein B in associated and free forms. Biochem. J. 137, 155–167.CrossRefGoogle Scholar
Luzzati, V., Tardieu, A. & Taupin, D. (1972). A pattern recognition approach to the phase problem: application to the X-ray diffraction study of biological membranes and model systems. J. molec. Biol. 64, 269–286.CrossRefGoogle Scholar
Luzzati, V., Tardieu, A., Mateu, L. & Stuhrmann, H. B. (1976). Structure of human serum lipoproteins in solution. I. Theory and techniques of an X-ray scattering approach using solvents of variable density. J. molec. Biol. 101, 115–127.Google Scholar
Mateu, L., Tardieu, A., Luzzati, V., Aggeebeck, L. & Scanu, A. M. (1972). On the structure of human serum low density lipoprotein. J. molec. Biol. 70, 105–116.Google Scholar
Mateu, L., Kirchhausen, T. & Camejo, G. (1977). A low temperature structural transition in human serum low density lipoproteins. Biochim. biophys. Acta 487, 243–245.Google Scholar
Mering, J. & Tchoubar, D. (1968). Interpretation de la diffusion centrale des rayons X par les Systèmes Poreux. I. J. appi. Crystallogr. 1, 153–165.CrossRefGoogle Scholar
Mittelbach, P. (1968). Zur Röntgenkleinwinkelstreuung verdüunter kolloider Systeme. VIII. Diskussion des Streuverhaltens regelmäβiger Korper und Methoden zur Bestimmung von Gröβe und Form kolloider Teilchen. Acta phys. austriaca 19, 53–102.Google Scholar
Morrisett, J. D., Jackson, R. L. & Gottro, A. M., JR. (1977 a). Lipoproteins: structure and function. A. Rev. Biochem. 44, 183–207.Google Scholar
Morrisett, J. D., Jackson, R. L. & Gotto, A. M., JR (1977 a). Lipid-protein interactions in the plasma lipoproteins. Biochim. biophys. Acta 472, 93–133.Google Scholar
Müller, K., Laggner, P., Kratky, O., Kostner, G., Holasek, A. & Glatter, O. (1974). X-ray small angle scattering of human plasma high density lipoprotein LpA from I-IDL3: application of a new evaluation method. FEBS Lett. 40, 213–218.CrossRefGoogle ScholarPubMed
Müller, K., Laggner, P., Glatter, O. & Kostner, G. (1978). The structure of human-plasma low-density lipoprotein 13. An X-ray small angle scattering study. Eur. J. Biochem. 82, 73–90.Google Scholar
Patsch, J. R., Sailer, S., Braunsteiner, H. & Forte, T. (1976). Elektronenoptische Charakterisierung menschlicher Plasmalipoproteine nach Isolierung mitteIstonaler Ultrazentrifugation. Dt. med. Wschr. 101, 1607–1610.Google Scholar
Pessen, H., Kumosinski, T. F. & Timasheff, S. N. (1973). Small-angle X-ray scattering. In Methods in Enzymology, part 9 (ed. Hirs, C. H. W. and Timasheff, S. N.), pp. 151–209. New York, London: Academic Press.Google Scholar
Porod, G. (1948). Die Abhängigkeit der Röntgen-Kleinwinkelstreuung von Form und Gröβe der kolloiden Teilchen in verdunnten Systemen. IV. Acta phys. austriaca 2, 255–292.Google Scholar
Porod, G. (1951). Die Rontgenkleinwinkelstreuung von dichtgepackten kolloiden Systemen: I. Kolloid. Zeitschrzft 124, 83–114.Google Scholar
Pilz, I. Small angle X-ray scattering. In Physical Principle and Techniques of Protein Chemistry, part C (ed. Leach, S. L.), pp. 141–243. New York, London: Academic Press.Google Scholar
Quarfordt, S. H., Oelschlager, M., Krigbaum, W. R., Nathans, A. M. & Hilderman, H. L. (1972). Liquid crystalline lipid in the plasma of humans with biliary obstruction. J. din. Invest. 51, 1979–1988.Google Scholar
Ritter, M. C. & Scanu, A. M. (1977). Role of apolipoprotein A-1 in the structure of human serum high density lipoproteins. Reconstitution studies. J. biol. Chem. 252, I208–1216.CrossRefGoogle ScholarPubMed
Scanu, A. M. & Wisdom, C. (1972). Serum lipoproteins. Structure and function. Ann. Rev. Biochem. 41, 703–730.Google Scholar
Scanu, A. M. (1972). Structural studies on serum lipoproteins. Biochim. biophys. Acta 265, 471–507.CrossRefGoogle Scholar
Scanu, A. M., Edelstein, C. & Keim, P. (1975). Serum lipoproteins. In The Plasma Proteins, vol. 1 (ed. Putnam, F. W.), pp. 317–391. New York: Academic Press.Google Scholar
Schelten, J. & Hossfeld, F. (1971). Application of spline functions to the correction of resolution errors in small angle scattering. J. appl. Crystallogr. 4, 210–223.Google Scholar
Schumaker, V. N. (1973). Hydrodynamic analysis of human low density lipoproteins. Acc. Chem. Res. 6, 398–403.CrossRefGoogle Scholar
Segrest, J. P. (1977). Amphipathic helixes and plasma lipoproteins. Thermodynamic and geometric considerations. Chem. Phys. Lipids 18, 7–22.CrossRefGoogle ScholarPubMed
Seidel, D. (1977). Studien zur Charaketerisierung und zum Stoffwechsel des Lipoprotein-X (Lp-X), des abnormen Lipoproteins der Cholestase. Kim. Wschr. 55, 611–623.Google Scholar
Shen, B. W., Scanu, A. M. & Kezdy, F. (1977). The structure of human serum lipoproteins inferred from compositional analysis. Proc. natn. Acad. Sci. U.S.A. 74, 837–841.CrossRefGoogle ScholarPubMed
Shipley, C. G., Atkinson, D. & Scanu, A. M. (1972). Small-angle X-ray scattering of human serum high-density lipoproteins. J. Supramol. Struct. 1, 98–104.Google Scholar
Stoffel, W., Zierenberg, O., Tungoal, B. & Schreiber, R. (1974). 13 nuclear magnetic resonance spectroscopic evidence for hydrophobic lipid-protein interactions in human serum highly-density lipoproteins. Proc. natn. Acad. Sci. U.S.A. 71, 3696–3700.Google Scholar
Stoffel, W., Därr, W. & Salm, K. P. (1977). Chemical proof of lipid. protein interactions by cross-linking photosensitive lipids to apoproteins. Intermolecular cross-linkage between high-density apolipoprotein A-I and lecithins and sphingomyelins. Hoppe Seyler's Z. Physiol. Chem. 358, 453–462.Google Scholar
Stuhrmann, H. B. & Kirste, R. G. (1965). Elimination der intrapartikulären Untergrundstreuung bei der Rontgenkleinwinkelstreuung an kompakten Teilchen (Proteinen). Z. phys. Chem. (Neue Folge) 46, 247–250.CrossRefGoogle Scholar
Stuhrmann, H. B. (1970). Ein neues Verfahren zur estimmung der Oberfiächenform und der inneren Stmktur von gelösten globulären Proteinen aus Röntgenkleinwinkelmessungen. Z. phys. Chem. (Neue Folge) 72, 177–184.CrossRefGoogle Scholar
Stuhrmann, H. B. (1974). Neutron small-angle scattering of biological macro-molecules in solution. J. appi. Crystallogr 7, 173–178.Google Scholar
Stuhrmann, H. B., Tardieu, A., Mateu, L., Sardet, C., Luzzati, V., Aggerbeck, L. & Scanu, A. M. (1975). Neutron scattering study of human serum low density lipoprotein. Proc. natn. Acad. Sci. U.S.A. 72, 2270–2Z73.CrossRefGoogle ScholarPubMed
Tanford, C. (1973). The Hydrophobic Effect: Formation of Micelles and Biological Membranes. New York: John Wiley & Sons.Google Scholar
Tardieu, A., Mateu, L., Sardet, C., Luzzati, V., Aggerbeck, L. & Scanu, A. M. (1976). Structure of human serum lipoproteins in solution. II. Small angle X-ray scattering study of HDL3 and LDL. J. molec. Biol. 101, 129–153.Google Scholar
Tardieu, A., Mateu, L., Sardet, C., Luzzati, V., Aggerbeck, L. & Scanu, A. M. (1976). Structure of human serum lipoproteins in solution. II. Small angle X-ray scattering study of HDL3 and LDL. Erratum. J. molec. Biol. 105, 459–460.Google Scholar
Timasheff, S. N., Lee, I. C., Pittz, E. P. & Tweedy, N. (1978). The interaction of tubulin and other proteins with structure-stabilizing solvents. Biochemistry, N.Y. (in the Press.)Google Scholar
Verdery, R. B. III & Nichols, A. V. (1975). Arrangement of lipids and protein in human serum high density lipoproteins. A proposed model. Chem. Phys. Lipids 14, 123–134.Google Scholar