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Membrane fusion proteins of enveloped animal viruses

Published online by Cambridge University Press:  17 March 2009

Judith White ,
Margaret Kielian  and
Ari Helenius
Judith White
Affiliation:
Section of Cell Biology, Yale University School of Medicine, 333 Cedar Street, P. O. Box 3333, New Haven, Connecticut 06510
Margaret Kielian
Affiliation:
Section of Cell Biology, Yale University School of Medicine, 333 Cedar Street, P. O. Box 3333, New Haven, Connecticut 06510
Ari Helenius
Affiliation:
Section of Cell Biology, Yale University School of Medicine, 333 Cedar Street, P. O. Box 3333, New Haven, Connecticut 06510
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Extract

In a living cell membrane-bound compartments are continuously either separated or united through fusion reactions, and literally thousands of such reactions take place every minute. The formation of membrane vesicles from pre-existing membranes, and their fusion with specific acceptor membranes, constitute a prerequisite for the transport of most impermeant molecules and macromolecules into the cell by endocytosis, out of the cell by exocytosis, and between the cellular organelles (Palade, 1975; Silverstein, 1978; Evered & Collins, 1982). Less frequent, but equally crucial, are fusion events in fertilization, cell division, polykaryon formation, enucleation, etc. (for reviews see Poste & Nicholson, 1978). Although a great deal is known about the properties and consequences of individual forms of membrane fusion in cellular systems, and about fusion in artificial lipid membranes, the molecular basis for the reactions remain largely unclear.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 16 , Issue 2 , May 1983 , pp. 151 - 195
Copyright
Copyright © Cambridge University Press 1983

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