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The Biochemical Basis of Long-Term Memory

Published online by Cambridge University Press:  17 March 2009

Richard B. Roberts  and
Louis B. Flexner
Richard B. Roberts
Affiliation:
Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, D.C.
Louis B. Flexner
Affiliation:
Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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Extract

Learning and memory are important elements of our daily lives, familiar to all through introspection. Yet the mechanisms underlying these processes are still for the most part unknown. Here are problems which combine a maximum of intrinsic and practical interest with a minimum of actual knowledge and understanding. Years of our lives are dedicated to the formation of certain long-term memories and behaviour patterns, yet we have only rudimentary notions of how such ‘schooling’ is best accomplished. There is no certainty in any aspect of the process. We are not sure whether relatively few cells or millions participate in a memory trace; whether these cells change as a whole, or whether the changes are limited to synaptic regions. In fact, we cannot be certain whether the changes are confined to the neurones or whether the glia also participate.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 2 , Issue 2 , May 1969 , pp. 135 - 173
Copyright
Copyright © Cambridge University Press 1969

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References

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