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Free energy cost and accuracy in branched selection processes of biosynthesis

Published online by Cambridge University Press:  17 March 2009

Clas Blomberg
Clas Blomberg
Affiliation:
Research Group for Theoretical Biophysics, Royal Institute of Technology, S-10044, Stockholm
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Extract

Selection in biochemical synthesis processes is a very important task: processes as protein or nucleic acid synthesis must be very accurate although the cell abounds with closely related molecules which, intuitively, should be difficult to distinguish. The mechanisms of selection and the underlying processes have been extensively studied in the last years, and the ideas have been developed into mathematical models to visualize the potentials of recognition and error correction. There are several aspects on this, the main aspect of the present work being the important fact that the cell must pay for the increased accuracy in terms of available free energy: processes are driven from equilibrium, and do away with appreciable dissipation.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 16 , Issue 4 , November 1983 , pp. 415 - 519
Copyright
Copyright © Cambridge University Press 1983

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