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DNA–carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7, 8-dihydrodiol 9, 10-epoxides studied by biochemical and biophysical techniques

Published online by Cambridge University Press:  17 March 2009

Astrid Gräslund  and
Bengt Jernström
Astrid Gräslund
Affiliation:
Department of Medical Biophysics, University of Umed, S-901 87 Umeå, Sweden
Bengt Jernström
Affiliation:
Department of Toxicology, Karolinska Institutet, S-104 01 Stockholm, Sweden
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Extract

Exposure to various chemicals, either due to occupation or lifestyle, is considered to be a major contributing factor to tumour formation in man (Higginson, 1969; Doll and Peto, 1981). An important and prevalent class of potent carcinogenic compounds present in he environment is polycyclic aromatic hydrocarbons (PAHs), which are found in various petroleum and combustion products derived from heat and power generation and motor vehicle exhausts (Baum, 1978). Furthermore, since PAHs are generally formed by pyrolysis of organic matters such as tobacco smoking and certain procedures of food preparation, the PAH exposure to humans is extensive.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 22 , Issue 3 , August 1989 , pp. 1 - 37
Copyright
Copyright © Cambridge University Press 1989

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