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Serum carotenoids as biomarkers of fruit and vegetable consumption in the New York Women's Health Study

Published online by Cambridge University Press:  02 January 2007

Anne Linda Van Kappel ,
Jean-Paul Steghens ,
Anne Zeleniuch-Jacquotte ,
Véronique Chajès ,
Paolo Toniolo  and
Elio Riboli
Anne Linda Van Kappel*
Affiliation:
Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert-Thomas, F-69372 Lyon Cedex 08, France
Jean-Paul Steghens
Affiliation:
Laboratoire de Biochimie C, Hôpital Edouard Herriot, 5 place d'Arsonval, F-69437 Lyon Cedex 03, France
Anne Zeleniuch-Jacquotte
Affiliation:
Nelson Institute of Environmental Medicine, New York University School of Medicine, 650 First Avenue, 5th Floor, New York, NY 10016, USA Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Véronique Chajès
Affiliation:
Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert-Thomas, F-69372 Lyon Cedex 08, France
Paolo Toniolo
Affiliation:
Nelson Institute of Environmental Medicine, New York University School of Medicine, 650 First Avenue, 5th Floor, New York, NY 10016, USA Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA Division of Epidemiology, Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, Room NB 9E2, New York, NY 10016, USA
Elio Riboli
Affiliation:
Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert-Thomas, F-69372 Lyon Cedex 08, France
*
*Corresponding author: Email [email protected]
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Abstract

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Objective:

To investigate the usefulness of serum carotenoids as biomarkers of fruit and vegetable consumption.

Design:

Reproducibility study on three repeat measurements of serum carotenoids. Correlation analysis of carotenoids and dietary food intake, and regression analysis of potential predictive parameters for serum carotenoid levels.

Setting:

New York, USA.

Subjects:

Women participating in the New York Women's Health Study, a prospective study of sex hormones, diet and breast cancer. Forty-eight women with three repeat blood samples and 302 women having a blood sample and a dietary history questionnaire.

Results:

Serum carotenoid concentrations were highly reproducible between one- and two-year repeat samples. Estimated fruit and vegetable consumption was positively correlated with serum carotenoid concentrations but correlation coefficients were low. Consumption of fruit was predictive for serum levels of beta-carotene, alpha-carotene and beta-cryptoxanthin, while vegetable consumption was predictive for serum beta-carotene, lutein, zeaxanthin and lycopene. Serum concentrations of cholesterol and triglycerides were predictive for serum carotenoids but adjustment for their levels had little or no influence on the correlation between fruit and vegetable consumption and serum carotenoid concentrations.

Conclusions:

One single serum measurement of alpha-carotene, beta-carotene and lutein can accurately rank subjects according to their usual serum level. Serum concentrations, however, correlate only moderately with estimated dietary intake of fruits or vegetables and should therefore be used with caution as biomarkers of fruit and vegetable intake.

Keywords

CarotenoidsSerumReproducibilityConsumption of fruit and vegetables
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 3 , June 2001 , pp. 829 - 835
Copyright
Copyright © CABI Publishing 2001

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