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Preventive nutritional supplementation throughout the reproductive life cycle

Published online by Cambridge University Press:  01 April 2001

Joan Fernández-Ballart  and
Michelle M Murphy
Joan Fernández-Ballart*
Affiliation:
Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Sant Llorenç 21, E-43201 Reus, Spain
Michelle M Murphy
Affiliation:
Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Sant Llorenç 21, E-43201 Reus, Spain
*
*Corresponding author: Email [email protected]
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Abstract

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Current interest in preventive nutritional supplementation strategies during the reproductive cycle in developed countries focuses mainly on iron and folic acid. Iron deficiency is the most common cause of anaemia. Inadequate iron nutrition is mainly a problem in developing countries but it also seems to affect a large proportion of pregnant women in the industrialised world. There is no chance for diet modification alone to meet iron requirements during pregnancy. However, dietary advice must be provided to increase iron intake and iron bioavailability. The best choice is prescribed supplementation adapted to the individual's needs.

Folic Acid supplementation during the periconceptional period reduces the occurrence and recurrence of neural tube defects (NTDs). According to the updated edition of American Dietary Reference Intakes, recommended dietary allowance for folate for women of childbearing age varies throughout the reproductive cycle from 400 μg day−1 of dietary folate equivalents (DFEs) for non-pregnant women, to 600 μg day−1 DFEs for pregnant women and 500 μg day−1 DFEs in lactating women. Increasing dietary folate, fortifying staple foods with folic acid or use of folic acid supplements can increase folate intake.

Keywords

IronFolic acidPreconceptionPregnancyLactationSupplementationFood fortificationDietary advice
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 6a , December 2001 , pp. 1363 - 1366
Copyright
Copyright © CABI Publishing 2001

References

1 Institute of Medicine. Iron nutrition during pregnancy. In: Nutrition During Pregnancy. Washington, DC: National Academy Press, 1990;272–98Google Scholar
2 Hercberg, S, Galan, P, Preziosi, P, Aissa, M. Consequences of iron deficiency in pregnant women: current issues. Clin. Drug. Invest. 2000; 19(Suppl.):1–7.CrossRefGoogle Scholar
3 Viteri, FE. The consequences of iron deficiency and anemia in pregnancy. In: Allen, L, King, J, Lönnerdal, B, eds. Nutrient Regulation During Pregnancy, Lactation and Infant Growth. New York: Plenum Press, 1994;127–39.CrossRefGoogle Scholar
4 Yip, R. Significance of an abnormally low or high hemoglobin concentration during pregnancy: special consideration of iron nutrition. Am. J. Clin. Nutr. 2000; 72(Suppl.): 272S–9S.CrossRefGoogle ScholarPubMed
5 Fernández-Ballart, J. Iron metabolism during pregnancy. Clin. Drug. Invest. 2000; 19:9–19.CrossRefGoogle Scholar
6 Beaton, GH. Iron needs during pregnancy: do we need to rethink our targets. Am. J. Clin. Nutr. 2000; 72(Suppl.):265S–71S.CrossRefGoogle ScholarPubMed
7 Hallberg, L. Results of surveys to assess iron status in Europe. Nutr. Rev. 1995; 53:314–22.CrossRefGoogle ScholarPubMed
8 Arija, V, Fernández-Ballart, J, Salas, J. Iron deficiency and iron deficiency anemia in the Spanish population. Med. Clín. (Barc.) 1997; 109:425–30.Google Scholar
9 Galán, P, Cherouvier, F, Fernández-Ballart, J, Martí-Henneberg, C, Herceberg, S. Biovailability and iron density in French and Spanish meals. Eur. J. Clin. Nutr. 1990; 44:157–63.Google Scholar
10 UNICEF/UNU/WHO/MI. Preventing Iron Deficiency in Women and Children: Technical Consensus on Key Issues and Resources for Programme Advocacy, Planning, and Implementation Technical Workship. New York: UNICEF, 1999.Google Scholar
11 Czeizel, AE, Dudás, I. Prevention of the first occurrence of neural-1tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 1992; 327:1832–5.CrossRefGoogle ScholarPubMed
12 MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338:131–7.CrossRefGoogle Scholar
13 Cuskelly, GC, McNulty, H, Scott, JM. Effect of increasing dietary folate on red cell folate: implications for prevention of neural tube defects. Lancet 1996; 347:657–9.CrossRefGoogle ScholarPubMed
14 Centers for Disease Control and Prevention. Recommendations for the use of folic acid to reduce the number of spina bifida cases and other neural tube defects. MMWR Morb. Mortal. Wkly. Rep. 1992; 41(RR-14):1–7.Google Scholar
15 Abramsky, L, Botting, B, Chapple, J, Stone, D. Has advice on periconceptional folate supplementation reduced neural tube defects? Lancet 1999; 354:998–9.CrossRefGoogle ScholarPubMed
16 Daly, S, Mills, JL, Molloy, AM, Conley, M, Lee, YJ, Kirke, PN, Weir, DG, Scott, JM. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet 1997; 350:1666–9.CrossRefGoogle ScholarPubMed
17 De Bree, A, van Dusseldorp, M, Brouwer, IA, van het Hof, KH, Steegers-Theunissen, RPM. Folate intake in Europe: recommended, actual and desired intake. Eur. J. Clin. Nutr. 1997; 51:643–60.CrossRefGoogle ScholarPubMed
18 Vioque, J, Quiles, J, Garcia de la Hera, M, Guillen, M, Ponce, E, Muñoz, P, Folic acid ingestion and associated factors in adult women 15–44 years of age in the Valencian Community. Med. Clin. (Barc.) 2000; 114:414–16.CrossRefGoogle ScholarPubMed
19 Daly, LE, Kirke, PN, Molloy, A, Weir, DG, Scott, JM. Folate levels and neural tube defects. JAMA 1995; 274:1698–1702.CrossRefGoogle ScholarPubMed
20 Whitehead, AS, Gallagher, P, Mills, JL, Kirke, PN, Burke, H, Molloy, AM, Weir, DG, Shields, DC, Scott, JM. A genetic defect in 5, 10-methylenetetrahydrofolate reductase in neural tube defects. QJM 1995; 88:763–6.Google Scholar
21 Christensen, B, Arbour, L, Tran, P, Leclerc, D, Sabbaghian, N, Platt, R, Gilfix, BM, Rosenblatt, DS, Gravel, RA, Forbes, P, Rozen, R. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells and risk of neural tube defects. Am. J. Med. Genet. 1999; 84:151–7.3.0.CO;2-T>CrossRefGoogle ScholarPubMed