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Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake

Published online by Cambridge University Press:  02 January 2007

AH Heald ,
R Sharma ,
SG Anderson ,
A Vyas ,
K Siddals ,
J Patel ,
D Bhatnagar ,
D Prabharkaran ,
A Rudenski  and
E Hughes
...Show all authors
AH Heald*
Affiliation:
University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester, M6 8HD, UK
R Sharma
Affiliation:
University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester, M6 8HD, UK
SG Anderson
Affiliation:
Clinical Epidemiology Group, University of Manchester Medical School, Manchester M13 9PT, UK
A Vyas
Affiliation:
Clinical Epidemiology Group, University of Manchester Medical School, Manchester M13 9PT, UK
K Siddals
Affiliation:
University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester, M6 8HD, UK
J Patel
Affiliation:
Clinical Epidemiology Group, University of Manchester Medical School, Manchester M13 9PT, UK
D Bhatnagar
Affiliation:
University Department of Medicine, Manchester Royal Infirmary, Manchester M13 9WL, UK
D Prabharkaran
Affiliation:
All India Institute of Medical Sciences, New Delhi, India
A Rudenski
Affiliation:
University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester, M6 8HD, UK
E Hughes
Affiliation:
Department of Clinical Biochemistry, Sandwell General Hospital, Birmingham, UK
P Durrington
Affiliation:
University Department of Medicine, Manchester Royal Infirmary, Manchester M13 9WL, UK
JM Gibson
Affiliation:
University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester, M6 8HD, UK
JK Cruickshank
Affiliation:
Clinical Epidemiology Group, University of Manchester Medical School, Manchester M13 9PT, UK
*
*Corresponding author: Email [email protected]
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Abstract

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Background

The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.

Objective

We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.

Design, subjects and setting

Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n = 205) compared with people still resident in the same villages of origin in India (n = 246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.

Results

Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1–153.6) vs. 100.9 (94.6–107.3) ng ml-1; F = 76.6, P < 0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9–33.0) vs. 56.5 (50.6–62.5) μg l-1; F = 48.4, P < 0.001). At both sites, IGF-I correlated positively with total energy (Spearman's ρ = 0.45, P < 0.001) and total fat (ρ = 0.44, P < 0.001) as did IGFBP-3 with total energy (ρ = 0.21, P < 0.05) and fat (ρ = 0.26, P < 0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (ρ = -0.27, P < 0.001) and fat intake (ρ = -0.26, P < 0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (β = 0.42, P = 0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.

Conclusion

In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.

Keywords

Insulin-like growth factorsInsulin-like growth factor binding proteinsDietEthnicityMigration
Type
Research Article
Information
Public Health Nutrition , Volume 8 , Issue 6 , September 2005 , pp. 620 - 627
Copyright
Copyright © The Authors 2005

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