Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-12-02T18:11:15.024Z Has data issue: false hasContentIssue false
  • English
  • Français

Vanadium: a possible aetiological factor in manic depressive illness

Published online by Cambridge University Press:  09 July 2009

Graham J. Naylor  and
Anne H. W. Smith
Graham J. Naylor*
Affiliation:
Department of Psychiatry, The University, Dundee
Anne H. W. Smith
Affiliation:
Department of Psychiatry, The University, Dundee
*
1Address for correspondence: Dr G. J. Naylor, Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DD1 9SY.
Get access Rights & Permissions [Opens in a new window]

Synopsis

The effect of Vitamin C in manic-depressive psychosis was assessed by a double-blind, placebo controlled, crossover trial. Both manic and depressed patients were significantly better following a single 3 g dose of Vitamin C than following a placebo.

Preliminary results of a double-blind, crossover comparison of normal vanadium intake with reduced intake in manic and depressed subjects are reported. Both manic and depressed patients were significantly better on reduced intake.

These results are in keeping with the suggestion that vanadium may be an aetiological factor in manic depressive illness.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 2 , May 1981 , pp. 249 - 256
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allers, R. (1914). Ergebnisse Stoffwechsel – pathologischen Untersuchungen bei Psychosen. Ill Das Manisch-depressive Irresein. Zeitschrift für die gesamte Neurologie und Psychiatrie 9, 585–590.Google Scholar
Beigel, A., Murphy, D. L. & Bunney, W. E. (1971). The manic state rating scale. Archives of General Psychiatry 25,257–262.CrossRefGoogle Scholar
Cantley, L. C. & Aisen, p. (1979). The fate of cytoplasmic vanadium. Journal of Biological Chemistry 254, 1781–1784.CrossRefGoogle ScholarPubMed
Cantley, L. C., Josephson, L., Warner, R., Yanagisava, M., Lechene, C. & Guidotti, G. (1977). Vanadate is a potent (Na, K)-ATPase inhibitor found in ATP derived from muscle. Journal of Biological Chemistry 252, 7421–7423.CrossRefGoogle ScholarPubMed
Chambers, C. (1980). Effects of digoxin on the clinical response to lithium carbonate in mania. Paper read to Scottish Psychiatric Research Society, 05 1980.Google Scholar
Coppen, A. J. (1960). Abnormality of the blood-cerebrospinal fluid barrier of patients suffering from a depressive illness. Journal of Neurology, Neurosurgery and Psychiatry 23, 156–161.CrossRefGoogle ScholarPubMed
Coppen, A. & Shaw, D. M. (1963). Mineral metabolism in melancholia. British Medical Journal ii, 1439–1444.CrossRefGoogle Scholar
Coppen, A., Shaw, D. M., Malleson, A. & Costain, R. (1966). Mineral metabolism in mania. British Medical Journal i, 71–75.CrossRefGoogle Scholar
Dick, D. A. T., Dick, E. G. & Naylor, G. J. (1981). Plasma vanadium concentration in manic depressive illness. Proceedings of the Physiological Society (in the press).Google Scholar
Glen, A. I. M. (1978). Lithium regulation of membrane ATPases. In Lithium in Medical Practice (ed. Johnson, F. N. and Johnson, S.), pp. 183–192. MTP Press: Lancaster.Google Scholar
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Hargreaves, W. A. (1968). Systematic nursing observation of psychopathology. Archives of General Psychiatry 18, 518–531.CrossRefGoogle ScholarPubMed
Johnston, B. B., Naylor, G. J., Dick, E. G., Hopwood, S. E. & Dick, D. A. T. (1980). Prediction of clinical course of bipolar manic depressive illness treated with lithium. Psychological Medicine 10, 329–334.CrossRefGoogle ScholarPubMed
Naylor, G. J. & LePoidevin, D. (1972). Sleep patterns in depressive states. British Journal of Medical Psychology 45, 171–176.CrossRefGoogle ScholarPubMed
Naylor, G. J., McNamee, H. B. & Moody, J. P. (1971). Changes in erythrocyte sodium and potassium on recovery from a depressive illness. British Journal of Psychiatry 118, 219–223.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T., Dick, E. G., LePoidevin, D. & Whyte, S. F. (1973). Erythrocyte membrane cation carrier in depressive illness. Psychological Medicine 3, 502–508.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T., Dick, E. G. & Moody, J. P. (1974). Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacologia 37, 81–86.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T., Dick, E. G., Worrall, E. P., Peet, M., Dick, P. & Boardman, L. J. (1976 a) Erythrocyte membrane cation carrier in mania. Psychological Medicine 6, 659–663.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T. & Dick, E. G. (1976 b). Erythrocyte membrane cation carrier, relapse rate of manicdepressive illness and response to lithium. Psychologica Medicine 6, 257–263.CrossRefGoogle ScholarPubMed
Naylor, G. J., Reid, A. H., Dick, D. A. T. & Dick, E. G. (1976 c). A biochemical study of short cycle manic depressive psychosis in mental defectives. British Journal of Psychiatry 128, 169–180.CrossRefGoogle ScholarPubMed
Naylor, G. J., Smith, A., Boardman, L. J., Dick, D. A. T., Dick, E. G. & Dick, P. (1977). Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects. Psychological Medicine 7, 229–233.CrossRefGoogle ScholarPubMed
Naylor, G. J., Smith, A. H. W., Dick, E. G., Dick, D. A. T., McHarg, A. & Chambers, C. A. (1980). Erythrocyte membrane cation carrier in manic depressive psychosis. Psychological Medicine 10, 521–525.CrossRefGoogle ScholarPubMed
Reid, A. H. & Naylor, G. J. (1976). Short cycle manic depressive psychosis in mental defectives: a clinical and physiological study. Journal of Mental Deficiency Research 20, 67–76.Google ScholarPubMed