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TRH by slow, continuous infusion: an antidepressant?

Published online by Cambridge University Press:  09 July 2009

W. Van Den Burg ,
H. M. Van Praag ,
E. R. H. Bos ,
D. A. Piers ,
A. K. Van Zanten  and
H. Doorenbos
W. Van Den Burg*
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
H. M. Van Praag
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
E. R. H. Bos
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
D. A. Piers
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
A. K. Van Zanten
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
H. Doorenbos
Affiliation:
Department of Biological Psychiatry, Department of Internal Medicine, Division of Endocrinology and Isotope Laboratory, University Hospital, Groningen, The Netherlands
*
11Address for correspondence: Dr W. van den Burg, Department of Biological Psychiatry, Oostersingel 59, Groningen, The Netherlands.
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Synopsis

A slow, continuous infusion of 1000 μg TRH (thyrotropin releasing hormone) over a period of 4 h had a very faint and diffuse short-lasting beneficial effect on a group of 10 depressive patients. This was assessed in a double blind cross-over trial with placebo. The effect was of no therapeutic value. No difference was found between the depressive patients and a control group of normal subjects in TSH response, T3 resin uptake, T4 or free thyroxine index values as a consequence of the TRH infusion.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 3 , August 1976 , pp. 393 - 397
Copyright
Copyright © Cambridge University Press 1976

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References

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