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Ten-year course of cognition in first-episode non-affective psychosis patients: PAFIP cohort

Published online by Cambridge University Press:  20 July 2020

José Manuel Rodríguez-Sánchez Open the ORCID record for José Manuel Rodríguez-Sánchez [Opens in a new window] ,
Esther Setién-Suero ,
Paula Suárez-Pinilla ,
Jaqueline Mayoral Van Son ,
Javier Vázquez-Bourgon ,
Patxi Gil López ,
Benedicto Crespo-Facorro ,
Rosa Ayesa-Arriola  and
PAFIP group
José Manuel Rodríguez-Sánchez*
Affiliation:
Red de Salud Mental de Bizkaia. Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12 48903, Barakaldo, Bizkaia, España CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain
Esther Setién-Suero
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain
Paula Suárez-Pinilla
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain
Jaqueline Mayoral Van Son
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain
Javier Vázquez-Bourgon
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain
Patxi Gil López
Affiliation:
Red de Salud Mental de Bizkaia. Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12 48903, Barakaldo, Bizkaia, España
Benedicto Crespo-Facorro
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain Hospital universitario Virgen del Roció, IBiS, Universidad de Sevilla, Spain
Rosa Ayesa-Arriola
Affiliation:
CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain
*
Author for correspondence: José Manuel Rodríguez-Sánchez, E-mail: [email protected]
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Abstract

Background

A large body of research states that cognitive impairment in schizophrenia is static. Nevertheless, most previous studies lack a control group or have small study samples or short follow-up periods.

Method

We aimed to address these limitations by studying a large epidemiological cohort of patients with first-episode schizophrenia spectrum disorders and a comparable control sample for a 10-year period.

Results

Our results support the generalized stability of cognitive functions in schizophrenia spectrum disorders considering the entire group. However, the existence of a subgroup of patients characterized by deteriorating cognition and worse long-term clinical outcomes must be noted. Nevertheless, it was not possible to identify concomitant factors or predictors of deterioration (all Ps > 0.05).

Conclusions

Cognitive functions in schizophrenia spectrum disorder are stable; however, a subgroup of subjects that deteriorate can be characterized.

Keywords

10-year follow-upcognitionfirst-episode psychosisstability
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 4 , March 2022 , pp. 770 - 779
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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Footnotes

*

Both authors contributed equally to the study.

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