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Specific amygdala response to masked fearful faces in post-traumatic stress relative to other anxiety disorders

Published online by Cambridge University Press:  27 September 2017

P. Neumeister ,
K. Feldker ,
C. Y. Heitmann ,
C. Buff ,
L. Brinkmann ,
M. Bruchmann  and
T. Straube
P. Neumeister*
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
K. Feldker
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
C. Y. Heitmann
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
C. Buff
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
L. Brinkmann
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
M. Bruchmann
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
T. Straube
Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany
*
Author for correspondence: P. Neumeister, E-mail: [email protected]
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Abstract

Background

Altered amygdala activation to fear-related stimuli has been proposed to be a potential neural correlate of heightened threat sensitivity in anxiety- and stress-related disorders. However, the role of stimulus awareness and disorder specificity remains widely unclear. Here we investigated amygdala responses to conscious and unconscious fearful faces in patients suffering from panic disorder (PD), generalized anxiety disorder (GAD), or post-traumatic stress disorder (PTSD) and in a large sample of healthy controls (HC).

Methods

During event-related functional magnetic resonance imaging participants (n = 120; 20 PD, 20 GAD, 20 PTSD, 60 HC) were confronted with briefly presented fearful faces, neutral faces, and non-faces in a backward masking paradigm. The design allowed for the analysis of trial-by-trial face detection performance and amygdala responses to fearful v. neutral faces.

Results

All participants exhibited increased amygdala activation to fearful v. neutral faces during conscious trials. Specifically during unconscious face processing, the PTSD, compared with all other groups, showed higher right basolateral (BLA) amygdala activity to fearful v. neutral faces.

Conclusions

The present study shows that BLA amygdala hyperactivity during unconscious, but not conscious, processing of fearful faces differentiates PTSD from the investigated disorders. This finding suggests an automatic and specific neural hyper-responsivity to general fear cues in PTSD and supports the idea of categorical differences between PTSD and other anxiety-related disorders.

Keywords

Amygdalaanxiety disorderbackward maskingPTSDunconscious
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 7 , May 2018 , pp. 1209 - 1217
Copyright
Copyright © Cambridge University Press 2017 

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