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The relationship between intellectual impairment and mood disorder in the first year after stroke

Published online by Cambridge University Press:  09 July 2009

Allan House ,
Martin Dennis ,
Charles Warlow ,
Keith Hawton  and
Andy Molyneux
Allan House*
Affiliation:
University Departments of Clinical Neurology, Psychiatry and Neuroradiology, Oxford; and the Department of Clinical Neuroscience, Western General Hospital, Edinburgh
Martin Dennis
Affiliation:
University Departments of Clinical Neurology, Psychiatry and Neuroradiology, Oxford; and the Department of Clinical Neuroscience, Western General Hospital, Edinburgh
Charles Warlow
Affiliation:
University Departments of Clinical Neurology, Psychiatry and Neuroradiology, Oxford; and the Department of Clinical Neuroscience, Western General Hospital, Edinburgh
Keith Hawton
Affiliation:
University Departments of Clinical Neurology, Psychiatry and Neuroradiology, Oxford; and the Department of Clinical Neuroscience, Western General Hospital, Edinburgh
Andy Molyneux
Affiliation:
University Departments of Clinical Neurology, Psychiatry and Neuroradiology, Oxford; and the Department of Clinical Neuroscience, Western General Hospital, Edinburgh
*
1Address for correspondence: Dr Allan House, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX.
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Synopsis

In a community-based study of patients with a first-ever stroke, intellectual impairment (as denned by scores on a common screening test for dementia, the Mini-Mental State Examination) was found in 26% at 1 month post-stroke, and in 21% at 6 and 12 month follow-up. Low scores on the screening test were associated with greater age, physical disability before the stroke, larger stroke lesion volumes as measured on CT scan, and non-stroke changes such as atrophy and white matter low attenuation on the CT scan. There was a negative correlation between scores on the Mini-Mental State Examination and symptom levels on two measures of mood disorder. However, there was no evidence of a specific relationship between major depression and low scores on the Mini-Mental State. We examined various aspects of the relationship between mood symptoms and low scores on the Mini-Mental State, but found no evidence to support the suggestion that this relationship represented an example of depressive pseudodementia. We discuss the significance of our findings for clinical psychiatry and neuropsychology.

Type
Orginal Articles
Information
Psychological Medicine , Volume 20 , Issue 4 , November 1990 , pp. 805 - 814
Copyright
Copyright © Cambridge University Press 1990

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