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Reduction of cortical volume in schizophrenia on magnetic resonance imaging

Published online by Cambridge University Press:  09 July 2009

I. Harvey ,
M. A. Ron ,
G. Du Boulay ,
D. Wicks ,
S. W. Lewis  and
R. M. Murray
I. Harvey
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
M. A. Ron*
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
G. Du Boulay
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
D. Wicks
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
S. W. Lewis
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
R. M. Murray
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
*
1Address for correspondence: Dr M. A. Ron, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG.
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Synopsis

The MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in excess of the loss of volume observed in other areas of the cortex. MRI abnormalities correlated poorly with clinical parameters, although both unemployment and poor pre-morbid adjustment predicted reduced cerebral volume and increased sulcal volume. These results question whether the medial temporal lobes are the only site of structural pathology in schizophrenia.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 3 , August 1993 , pp. 591 - 604
Copyright
Copyright © Cambridge University Press 1993

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