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Prodromal dementia with Lewy bodies

Published online by Cambridge University Press:  03 April 2014

P. C. Donaghy*
Affiliation:
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
J. T. O'Brien
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
A. J. Thomas
Affiliation:
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
*
* Address for correspondence: Dr P. C. Donaghy, Level 3, Biomedical Research Building, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK. (Email: [email protected])

Abstract

Background

The clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB).

Method

A Medline search was carried out to identify articles with original data on the prodromal presentation of DLB.

Results

In MCI cohorts that progress to dementia, the proportion diagnosed with DLB is similar to that reported in dementia cohorts. Prodromal DLB may present as any MCI subtype, although visuospatial and executive domains may be most commonly affected. Rapid eye movement (REM) sleep behaviour disorder (RBD), autonomic symptoms, hyposmia, hallucinations and motor symptoms seem to be more common in prodromal DLB than in prodromal Alzheimer's disease (AD). Some of these symptoms can precede the diagnosis of DLB by several years. There has been little research into the use of biomarkers in prodromal DLB, although in RBD cohorts, clinical and imaging biomarkers have been associated with the development of DLB.

Conclusions

The evidence available suggests that prodromal DLB may be differentiated from other dementia prodromes in most cases. Further research is needed to confirm this, and to assess the utility of biomarkers such as 123I-FP-CIT and 123I-MIBG imaging.

Type
Review Articles
Copyright
Copyright © Cambridge University Press 2014 

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References

Aisen, PS, Vellas, B, Hampel, H (2013). Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease. Nature Reviews. Drug Discovery 12, 324.Google Scholar
Albert, MS, DeKosky, ST, Dickson, D, Dubois, B, Feldman, HH, Fox, NC, Gamst, A, Holtzman, DM, Jagust, WJ, Petersen, RC, Snyder, PJ, Carrillo, MC, Thies, B, Phelps, CH (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia 7, 270279.CrossRefGoogle ScholarPubMed
Albin, R, Koeppe, R (2006). Rapid loss of striatal VMAT2 binding associated with onset of Lewy body dementia. Movement Disorders 21, 287288.Google Scholar
Albin, RL, Burke, JF, Koeppe, RA, Giordani, B, Gilman, S, Frey, KA (2013). Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging. Journal of Nuclear Medicine 54, 887893.Google Scholar
Auning, E, Rongve, A, Fladby, T, Booij, J, Hortobagyi, T, Siepel, FJ, Ballard, C, Aarsland, D (2011). Early and presenting symptoms of dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 32, 202208.Google Scholar
Ballard, C, Grace, J, McKeith, I, Holmes, C (1998). Neuroleptic sensitivity in dementia with Lewy bodies and Alzheimer's disease. Lancet 351, 10321033.CrossRefGoogle ScholarPubMed
Boeve, BF, Silber, MH, Ferman, TJ, Kokmen, E, Smith, GE, Ivnik, RJ, Parisi, JE, Olson, EJ, Petersen, RC (1998). REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology 51, 363370.Google Scholar
Boeve, BF, Silber, MH, Parisi, JE, Dickson, DW, Ferman, TJ, Benarroch, EE, Schmeichel, AM, Smith, GE, Petersen, RC, Ahlskog, JE, Matsumoto, JY, Knopman, DS, Schenck, CH, Mahowald, MW (2003). Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61, 4045.Google Scholar
Bombois, S, Debette, S, Bruandet, A, Delbeuck, X, Delmaire, C, Leys, D, Pasquier, F (2008). Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients. Stroke 39, 20462051.Google Scholar
Chiba, Y, Fujishiro, H, Iseki, E, Ota, K, Kasanuki, K, Hirayasu, Y, Satoa, K (2012). Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 33, 273281.Google Scholar
Claassen, DO, Josephs, KA, Ahlskog, JE, Silber, MH, Tippmann-Peikert, M, Boeve, BF (2010). REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 75, 494499.Google Scholar
Clerici, F, Del Sole, A, Chiti, A, Maggiore, L, Lecchi, M, Pomati, S, Mosconi, L, Lucignani, G, Mariani, C (2009). Differences in hippocampal metabolism between amnestic and non-amnestic MCI subjects: automated FDG-PET image analysis. Quarterly Journal of Nuclear Medicine and Molecular Imaging 53, 646657.Google Scholar
Dang-Vu, TT, Gagnon, JF, Vendette, M, Soucy, JP, Postuma, RB, Montplaisir, J (2012). Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Neurology 79, 23022306.CrossRefGoogle ScholarPubMed
Dubois, B, Feldman, HH, Jacova, C, Cummings, JL, Dekosky, ST, Barberger-Gateau, P, Delacourte, A, Frisoni, G, Fox, NC, Galasko, D, Gauthier, S, Hampel, H, Jicha, GA, Meguro, K, O'Brien, J, Pasquier, F, Robert, P, Rossor, M, Salloway, S, Sarazin, M, de Souza, LC, Stern, Y, Visser, PJ, Scheltens, P (2010). Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurology 9, 11181127.Google Scholar
Dugger, BN, Boeve, BF, Murray, ME, Parisi, JE, Fujishiro, H, Dickson, DW, Ferman, TJ (2012). Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Movement Disorders 27, 7278.Google Scholar
Fayed, N, Davila, J, Oliveros, A, Castillo, J, Medrano, JJ (2008). Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia. Academic Radiology 15, 10891098.CrossRefGoogle ScholarPubMed
Ferman, TJ, Boeve, BF, Smith, GE, Lin, SC, Silber, MH, Pedraza, O, Wszolek, Z, Graff-Radford, NR, Uitti, R, Van Gerpen, J, Pao, W, Knopman, D, Pankratz, VS, Kantarci, K, Boot, B, Parisi, JE, Dugger, BN, Fujishiro, H, Petersen, RC, Dickson, DW (2011). Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology 77, 875882.Google Scholar
Fischer, P, Jungwirth, S, Zehetmayer, S, Weissgram, S, Hoenigschnabl, S, Gelpi, E, Krampla, W, Tragl, KH (2007). Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology 68, 288291.Google Scholar
Fujishiro, H, Ferman, TJ, Boeve, BF, Smith, GE, Graff-Radford, NR, Uitti, RJ, Wszolek, ZK, Knopman, DS, Petersen, RC, Parisi, JE, Dickson, DW (2008). Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases. Journal of Neuropathology and Experimental Neurology 67, 649656.Google Scholar
Fujishiro, H, Iseki, E, Nakamura, S, Kasanuki, K, Chiba, Y, Ota, K, Murayama, N, Sato, K (2013). Dementia with Lewy bodies: early diagnostic challenges. Psychogeriatrics 13, 128138.Google Scholar
Gaenslen, A, Swid, I, Liepelt-Scarfone, I, Godau, J, Berg, D (2011). The patients’ perception of prodromal symptoms before the initial diagnosis of Parkinson's disease. Movement Disorders 26, 653658.Google Scholar
Harvey, RJ, Skelton-Robinson, M, Rossor, MN (2003). The prevalence and causes of dementia in people under the age of 65 years. Journal of Neurology, Neurosurgery, and Psychiatry 74, 12061209.CrossRefGoogle ScholarPubMed
Iranzo, A, Lomena, F, Stockner, H, Valldeoriola, F, Vilaseca, I, Salamero, M, Molinuevo, JL, Serradell, M, Duch, J, Pavia, J, Gallego, J, Seppi, K, Hogl, B, Tolosa, E, Poewe, W, Santamaria, J (2010). Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurology 9, 10701077.Google Scholar
Iranzo, A, Tolosa, E, Gelpi, E, Molinuevo, JL, Valldeoriola, F, Serradell, M, Sanchez-Valle, R, Vilaseca, I, Lomena, F, Vilas, D, Llado, A, Gaig, C, Santamaria, J (2013). Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurology 12, 443453.CrossRefGoogle ScholarPubMed
Jicha, GA, Schmitt, FA, Abner, E, Nelson, PT, Cooper, GE, Smith, CD, Markesbery, WR (2010). Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiology of Aging 31, 18051813.Google Scholar
McKeith, IG, Dickson, DW, Lowe, J, Emre, M, O'Brien, JT, Feldman, H, Cummings, J, Duda, JE, Lippa, C, Perry, EK, Aarsland, D, Arai, H, Ballard, CG, Boeve, B, Burn, DJ, Costa, D, Del Ser, T, Dubois, B, Galasko, D, Gauthier, S, Goetz, CG, Gomez-Tortosa, E, Halliday, G, Hansen, LA, Hardy, J, Iwatsubo, T, Kalaria, RN, Kaufer, D, Kenny, RA, Korczyn, A, Kosaka, K, Lee, VM, Lees, A, Litvan, I, Londos, E, Lopez, OL, Minoshima, S, Mizuno, Y, Molina, JA, Mukaetova-Ladinska, EB, Pasquier, F, Perry, RH, Schulz, JB, Trojanowski, JQ, Yamada, M (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65, 18631872.Google Scholar
Molano, J, Boeve, B, Ferman, T, Smith, G, Parisi, J, Dickson, D, Knopman, D, Graff-Radford, N, Geda, Y, Lucas, J, Kantarci, K, Shiung, M, Jack, C, Silber, M, Pankratz, VS, Petersen, R (2010). Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain 133, 540556.Google Scholar
Palmqvist, S, Hertze, J, Minthon, L, Wattmo, C, Zetterberg, H, Blennow, K, Londos, E, Hansson, O (2012). Comparison of brief cognitive tests and CSF biomarkers in predicting Alzheimer's disease in mild cognitive impairment: six-year follow-up study. PLoS One 7, e38639.CrossRefGoogle ScholarPubMed
Pardo, JV, Lee, JT, Kuskowski, MA, Munch, KR, Carlis, JV, Sheikh, SA, Surerus, C, Lewis, SM, McCarten, JR, Fink, H, McPherson, S, Shah, HH, Rottunda, S, Dysken, MW (2010). Fluorodeoxyglucose positron emission tomography of mild cognitive impairment with clinical follow-up at 3 years. Alzheimer's and Dementia 6, 326333.CrossRefGoogle ScholarPubMed
Paulsen, JS, Langbehn, DR, Stout, JC, Aylward, E, Ross, CA, Nance, M, Guttman, M, Johnson, S, MacDonald, M, Beglinger, LJ, Duff, K, Kayson, E, Biglan, K, Shoulson, I, Oakes, D, Hayden, M (2008). Detection of Huntington's disease decades before diagnosis: the Predict-HD study. Journal of Neurology, Neurosurgery, and Psychiatry 79, 874880.CrossRefGoogle ScholarPubMed
Petersen, RC (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine 256, 183194.Google Scholar
Petersen, RC, Doody, R, Kurz, A, Mohs, RC, Morris, JC, Rabins, PV, Ritchie, K, Rossor, M, Thal, L, Winblad, B (2001). Current concepts in mild cognitive impairment. Archives of Neurology 58, 19851992.Google Scholar
Petersen, RC, Parisi, JE, Dickson, DW, Johnson, KA, Knopman, DS, Boeve, BF, Jicha, GA, Ivnik, RJ, Smith, GE, Tangalos, EG, Braak, H, Kokmen, E (2006). Neuropathologic features of amnestic mild cognitive impairment. Archives of Neurology 63, 665672.Google Scholar
Petersen, RC, Smith, GE, Waring, SC, Ivnik, RJ, Tangalos, EG, Kokmen, E (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology 56, 303308.Google Scholar
Postuma, RB, Gagnon, JF, Pelletier, A, Montplaisir, J (2013). Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies. Movement Disorders 28, 597604.CrossRefGoogle ScholarPubMed
Postuma, RB, Gagnon, JF, Vendette, M, Desjardins, C, Montplaisir, JY (2011). Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Annals of Neurology 69, 811818.Google Scholar
Postuma, RB, Gagnon, JF, Vendette, M, Fantini, ML, Massicotte-Marquez, J, Montplaisir, J (2009). Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 72, 12961300.Google Scholar
Postuma, RB, Lanfranchi, PA, Blais, H, Gagnon, JF, Montplaisir, JY (2010). Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Movement Disorders 25, 23042310.Google Scholar
Postuma, RB, Lang, AE, Gagnon, JF, Pelletier, A, Montplaisir, JY (2012). How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain 135, 18601870.Google Scholar
Saito, Y, Murayama, S (2007). Neuropathology of mild cognitive impairment. Neuropathology 27, 578584.Google Scholar
Schenck, CH, Boeve, BF, Mahowald, MW (2013). Delayed emergence of a parkinsonian disorder or dementia in 81% of older males initially diagnosed with idiopathic REM sleep behavior disorder (RBD): a 16-year update on a previously reported series. Sleep Medicine 14, 744748.Google Scholar
Schneider, JA, Arvanitakis, Z, Leurgans, SE, Bennett, DA (2009). The neuropathology of probable Alzheimer disease and mild cognitive impairment. Annals of Neurology 66, 200208.Google Scholar
Siepel, FJ, Rongve, A, Buter, TC, Beyer, MK, Ballard, CG, Booij, J, Aarsland, D (2013). (123I)FP-CIT SPECT in suspected dementia with Lewy bodies: a longitudinal case study. British Medical Journal Open 3, e002642.Google ScholarPubMed
Tabrizi, SJ, Reilmann, R, Roos, RA, Durr, A, Leavitt, B, Owen, G, Jones, R, Johnson, H, Craufurd, D, Hicks, SL, Kennard, C, Landwehrmeyer, B, Stout, JC, Borowsky, B, Scahill, RI, Frost, C, Langbehn, DR (2012). Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurology 11, 4253.Google Scholar
Tiraboschi, P, Hansen, LA, Alford, M, Merdes, A, Masliah, E, Thal, LJ, Corey-Bloom, J (2002). Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease. Archives of General Psychiatry 59, 946951.Google Scholar
Troster, AI (2008). Neuropsychological characteristics of dementia with Lewy bodies and Parkinson's disease with dementia: differentiation, early detection, and implications for ‘mild cognitive impairment’ and biomarkers. Neuropsychology Review 18, 103119.Google Scholar
Vann Jones, SA, O'Brien, JT (2014). The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychological Medicine 44, 673683.Google Scholar
Winblad, B, Palmer, K, Kivipelto, M, Jelic, V, Fratiglioni, L, Wahlund, LO, Nordberg, A, Backman, L, Albert, M, Almkvist, O, Arai, H, Basun, H, Blennow, K, de Leon, M, DeCarli, C, Erkinjuntti, T, Giacobini, E, Graff, C, Hardy, J, Jack, C, Jorm, A, Ritchie, K, van Duijn, C, Visser, P, Petersen, RC (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine 256, 240246.Google Scholar
Yoshizawa, H, Vonsattel, JP, Honig, LS (2013). Early neuropsychological discriminants for Lewy body disease: an autopsy series. Journal of Neurology, Neurosurgery, and Psychiatry 84, 13261330.Google Scholar