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Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia

Published online by Cambridge University Press:  09 July 2009

T. Shioiri ,
Y. Oshitani ,
T. Kato ,
J. Murashita ,
H. Hamakawa ,
T. Inubushi ,
T. Nagata  and
S. Takahashi
T. Shioiri*
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
Y. Oshitani
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
T. Kato
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
J. Murashita
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
H. Hamakawa
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
T. Inubushi
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
T. Nagata
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
S. Takahashi
Affiliation:
Departments of Psychiatry and Radiology, and the Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
*
1Address for correspondence: Dr Toshiki Shioiri, Department of Psychiatry. Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, 520–21, Japan.
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Synopsis

The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by magnetic resonance imaging (MRI). Significantly higher incidence of Grade 3–4 CSP (moderate to large) compared with the controls was found only in the schizophrenics. When a broader interpretation of CSP, including indeterminant (Grade 1) and small (Grade 2) CSP was used, three additional patients with bipolar disorder were found to have Grade 1–2 CSP, and the total prevalence of Grade 1–4 CSP in the patients with bipolar disorder was significantly higher than that in the control subjects but slightly lower than that in the schizophrenic patients. CSP was not observed in any patient with major depression. There were no differences between the patients with and without CSP in age, sex, education, or the duration of illness. These findings are consistent with the hypothesis that neurodevelopmental abnormality may be present in schizophrenia, and such an abnormality may also be present in some patients with bipolar disorder.

Type
Brief Communication
Information
Psychological Medicine , Volume 26 , Issue 2 , March 1996 , pp. 431 - 434
Copyright
Copyright © Cambridge University Press 1996

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References

REFERENCES

American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, Revised. American Psychiatric Association Press: Washington, DC.Google Scholar
Degreef, G., Lantos, G., Bogerts, B., Ashtari, M. & Lieberman, J. (1992 a). Abnormalities of the septum pellucidum on MR scans in first-episode schizophrenic patients. American Journal of Neuroradiology 13, 835–840.Google ScholarPubMed
Degreef, G., Bogerts, B., Falkai, P., Greve, B., Lantos, G., Ashtari, M. & Lieberman, J. (1992 b). Increased prevalence of the cavum septum pellucidum in magnetic resonance scans and post-mortem brains of schizophrenic patients. Psychiatry Research: Neuroimaging 45, 1–13.Google Scholar
DeLisi, L. E., Hoff, A. L., Kushner, M. & Degreef, G. (1993). Increased prevalence of cavum septum pellucidum in schizophrenia. Psychiatry Research: Neuroimaging 50, 193–199.Google Scholar
Hollingshead, R. B. (1965). Two-factor Index of Social Position. Yale Station: New Haven, CT.Google Scholar
Jurjus, G. J., Nasrallah, H. A., Olson, S. C. & Schwarzkopf, S. B. (1993 a). Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study. Psychological Medicine 23, 319–322.Google Scholar
Kato, T., Shioiri, T., Murashita, J., Hamakawa, H., Inubushi, T. & Takahashi, S. (1994). Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatry Research: Neuroimaging 55, 41–50.CrossRefGoogle ScholarPubMed
Lewis, S. W., Reveley, M. A., David, A. S. & Ron, M. A. (1988). Agenesis of the corpus callosum and schizophrenia: a case report. Psychological Medicine 18, 341–347.CrossRefGoogle ScholarPubMed
Lohr, J. B. & Bracha, H. S. (1992). A monozygotic mirror-image twin pair with discordant psychiatric illnesses: a neuropsychiatric and neurodevelopmental evaluation. American Journal of Psychiatry 149, 1091–1095.Google Scholar
Markow, T. A. & Gottesman, I. I. (1989). Fluctuating dermatoglyphic asymmetry in psychotic twins. Psychiatry Research 29, 37–43.Google Scholar
Nasrallah, H. A. (1991). Neurodevelopmental aspects of bipolar affective disorder. Biological Psychiatry 29, 1–2.Google Scholar
Scott, T. F., Prince, T. R. P., George, M. S., Brillman, J. & Rothfus, W. (1993). Midline cerebral malformations and schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences 5, 287–293.Google ScholarPubMed
Shioiri, T., Kato, T., Inubushi, T., Murashita, J. & Takahashi, S. (1994). Correlations of phosphomonoesters measured by phosphorus-31 magnetic resonance spectroscopy in the frontal lobes and negative symptoms in schizophrenia. Psychiatry Research: Neuroimaging 55, 223–235.Google Scholar
Swayze, V. W., Andreasen, N. C., Ehrhardt, J. C., Yuh, W. T., Alliger, R. J. & Cohen, G. A. (1990). Developmental abnormalities of the corpus callosum in schizophrenia. Archives of Neurology 47, 805–808.CrossRefGoogle ScholarPubMed
Swayze, V. W. II, Andreasen, N. C., Alliger, R. J., Yuh, W. T. C. & Ehrhardt, J. C. (1992). Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biological Psychiatry 33, 221–240.Google Scholar