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Prevalence and determinants of cognitive impairment in the euthymic phase of bipolar disorders: results from the FACE-BD cohort

Published online by Cambridge University Press:  08 May 2018

Paul Roux Open the ORCID record for Paul Roux [Opens in a new window] ,
Bruno Etain ,
Anne-Sophie Cannavo ,
Valérie Aubin ,
Bruno Aouizerate ,
Jean-Michel Azorin ,
Frank Bellivier ,
Raoul Belzeaux ,
Thierry Bougerol  and
Iréna Cussac
...Show all authors
Paul Roux*
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
Bruno Etain
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Affective Disorders, London, UK
Anne-Sophie Cannavo
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
Valérie Aubin
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France
Bruno Aouizerate
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France
Jean-Michel Azorin
Affiliation:
Fondation Fondamental, Créteil, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France
Frank Bellivier
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France
Raoul Belzeaux
Affiliation:
Fondation Fondamental, Créteil, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France
Thierry Bougerol
Affiliation:
Fondation Fondamental, Créteil, France University Grenoble Alpes, CS 40700, 38058 Grenoble Cedex 9, France CHU de Grenoble et des Alpes, CS10217, F-38043 Grenoble, France Grenoble Institut des Neurosciences (GIN) Inserm U 836, Chemin Fortuné Ferrini, 38706 La Tronche, France
Iréna Cussac
Affiliation:
Fondation Fondamental, Créteil, France Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, BP489, 98012 Monaco, France
Philippe Courtet
Affiliation:
Fondation Fondamental, Créteil, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France
Jean-Pierre Kahn
Affiliation:
Fondation Fondamental, Créteil, France Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France
Marion Leboyer
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France
Katia M'Bailara
Affiliation:
Fondation Fondamental, Créteil, France Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France Laboratoire de Psychologie, EA4139, Université de Bordeaux, France
Marion Perrin Payet
Affiliation:
Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France
Emilie Olié
Affiliation:
Fondation Fondamental, Créteil, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France
Chantal Henry
Affiliation:
Fondation Fondamental, Créteil, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France
Christine Passerieux
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France
the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Affiliation:
Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France Fondation Fondamental, Créteil, France AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences, Paris, France Université Paris Diderot, UMR-S 1144, Paris, France Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Affective Disorders, London, UK Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux, France AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, 13274 Marseille, France University Grenoble Alpes, CS 40700, 38058 Grenoble Cedex 9, France CHU de Grenoble et des Alpes, CS10217, F-38043 Grenoble, France Grenoble Institut des Neurosciences (GIN) Inserm U 836, Chemin Fortuné Ferrini, 38706 La Tronche, France Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, BP489, 98012 Monaco, France Department of Emergency Psychiatry & Post Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France INSERM U1061, Montpellier, France Pôle de Psychiatrie et Psychologie Clinique – Centre Psychothérapique de Nancy, 54520 Laxou, France Université de Lorraine, Nancy, France AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil 94000, France Université Paris Est, Faculté de Médecine, Créteil 94000, France Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil 94000, France Laboratoire de Psychologie, EA4139, Université de Bordeaux, France Institut Pasteur, Unité Perception et Mémoire, F-75015 Paris, France
*
Author for correspondence: Paul Roux, E-mail: [email protected]
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Abstract

Background

Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive impairment, based on psychometric properties, to estimate the prevalence of neuropsychological deficits in euthymic BD, and identify risk factors for cognitive deficits using a multivariate approach.

Methods

We investigated neuropsychological performance in 476 euthymic patients with BD recruited via the French network of BD expert centres. We used a battery of tests, assessing five domains of cognition. Five criteria for the identification of neuropsychological impairment were tested based on their convergent and concurrent validity. Uni- and multivariate logistic regressions between cognitive impairment and several clinical and demographic variables were performed to identify risk factors for neuropsychological impairment in BD.

Results

One cut-off had satisfactory psychometric properties and yielded a prevalence of 12.4% for cognitive deficits in euthymic BD. Antipsychotics use were associated with the presence of a cognitive deficit.

Conclusions

This is the first study to validate a criterion for clinically significant cognitive impairment in BD. We report a lower prevalence of cognitive impairment than previous studies, which may have overestimated its prevalence. Patients with euthymic BD and cognitive impairment may benefit from cognitive remediation.

Keywords

Antipsychoticattentionbipolar disordercognitioneuthymicexecutivememorypsychometricremediationsocial functioning
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 3 , February 2019 , pp. 519 - 527
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

List of FondaMental Advanced Center of Expertise (FACE-BD): FACE-BD Clinical Coordinating Center (Fondation FondaMental); B. Etain, C. Henry, E. Olié, and M. Leboyer; FACE-BD Data Coordinating Center (Fondation FondaMental); V. Barteau, O. Godin, H. Laouamri, and Karmene Souryis; FACE-BD Clinical Sites and Principal Collaborators in France;AP-HP, DHU PePSY, Pôle de Psychiatrie et d'Addictologie des Hôpitaux Universitaires H Mondor, Créteil; S. Hotier, A. Pelletier, and A. Raust; AP-HP, GH Saint-Louis–Lariboisière–Fernand Widal, Pôle Neurosciences, Paris; F. Bellivier, M. Carminati, B. Etain, and P. Seguin; Hôpital C. Perrens, Centre Expert Trouble Bipolaire, Service de Psychiatrie Adulte, Pôle 3-4-7, Bordeaux; B. Antoniol, A. Desage, S. Gard, A. Jutant, K. Mbailara, I. Minois, and L. Zanouy; Département d'Urgence et Post Urgence Psychiatrique, CHRU Montpellier, Montpellier; S. Bonnet, F. Coppola, P. Courtet, D. Ducasse, M. Gachet, L. Matos, F. Molière, B. Noisette, E. Olié and G. Tarquini; Département de Psychiatrie, Hôpital Sainte Marguerite, Marseille; J. M. Azorin, R. Belzeaux, N. Corréard, J. L. Consoloni, F. Groppi, L. Lescalier. J. Montant and N. Viglianese; Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy; R. Cohen, J.P. Kahn, P. Kieffer, and O. Wajsbrot-Elgrabli; Clinique Universitaire de Psychiatrie, CHU de Grenoble et des Alpes, Grenoble; T. Bougerol, B. Fredembach, S. Garçon, P. Grignon, A. Perrin, and M. Polosan; Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d'adultes, Le Chesnay; A.M. Galliot, I. Grévin, A.S. Cannavo, N. Kayser, C. Passerieux, and P. Roux; Service de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco; V. Aubin, I. Cussac, M.A Dupont, J. Loftus, and I. Medecin.

References

Bonnin, CM et al. (2010) Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. Journal of Affective Disorders 121, 156–160.Google Scholar
Bourne, C et al. (2013) Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatrica Scandinavica 128, 149–162.Google Scholar
Burdick, KE et al. (2014) Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. Psychological Medicine 44, 3083–3096.Google Scholar
Cipriani, G et al. (2017) Bipolar disorder and cognitive dysfunction: a complex link. The Journal of Nervous and Mental Disease 205, 743–756.Google Scholar
Conners, CK and Staff, M (2000) Conners’ Continuous Performance Test II. North Tonawanda, NY: Multi-Health Systems Inc.Google Scholar
Cullen, B et al. (2015) Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: cross-sectional study of 143,828 UK Biobank participants. European Psychiatry: the Journal of the Association of European Psychiatrists 30, 950–958.Google Scholar
Cullen, B et al. (2016) Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. Journal of Affective Disorders 205, 165–181.Google Scholar
Delis, DC (2000) CVLT-II: California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation.Google Scholar
First, MB et al. (1997). User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I: Clinician Version. Washington, DC: American Psychiatric Pub.Google Scholar
Fleiss, JL (1981) Statistical Methods for Rates and Proportions, 2nd Edn. New York: John Wiley & Sons.Google Scholar
Friedman, JI et al. (2002) A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia. Biological Psychiatry 51, 349–357.Google Scholar
Glahn, DC et al. (2007) The neurocognitive signature of psychotic bipolar disorder. Biological Psychiatry 62, 910–916.Google Scholar
Godefroy, O (2012) La batterie GREFEX: données normatives. In Fonctions exécutives et pathologies neurologiques et psychiatriques: Évaluation en pratique clinique. Paris: De Boeck Supérieur - Solal, pp. 231–252.Google Scholar
Golden, CJ (1978) A Manual for the Clinical and Experimental Use of the Stroop Color and Word Test. Chicago, IL: Stoelting.Google Scholar
Gualtieri, CT and Morgan, DW (2008) The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. The Journal of Clinical Psychiatry 69, 1122–1130.Google Scholar
Guy, W (1976) Clinical global impression scale. In Guy, W (ed.), The ECDEU Assessment Manual for Psychopharmacology, vol. 76. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs, pp. 218–222Google Scholar
Heaton, R et al. (2004) Revised Comprehensive Norms for an Expanded Halstead-Reitan Battery: Demographically Adjusted Neuropsychological Norms for African American and Caucasian Adults. Lutz, FL: Psychological Assessment Resources.Google Scholar
Jamrozinski, K et al. (2009) Neurocognitive functions in euthymic bipolar patients. Acta Psychiatrica Scandinavica 119, 365–374.Google Scholar
Jones, SH et al. (1995) A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). The British Journal of Psychiatry 166, 654–659.Google Scholar
Keefe, RS, Eesley, CE and Poe, MP (2005) Defining a cognitive function decrement in schizophrenia. Biological Psychiatry 57, 688–691.Google Scholar
Kremen, WS et al. (2000) The paradox of normal neuropsychological function in schizophrenia. Journal of Abnormal Psychology 109, 743.Google Scholar
Landau, S, Raymont, V and Frangou, S (2003) The maudsley bipolar disorder project: the effect of medication, family history, and duration of illness on IQ and memory in bipolar I disorder. Journal of Clinical Psychiatry 64, 86–93.Google Scholar
Levy, B (2013) Autonomic nervous system arousal and cognitive functioning in bipolar disorder. Bipolar Disorders 15, 70–79.Google Scholar
Lezak, MD (2004) Neuropsychological Assessment. New York: Oxford University Press.Google Scholar
Martino, DJ et al. (2014) Toward the identification of neurocognitive subtypes in euthymic patients with bipolar disorder. Journal of Affective Disorders 167, 118–124.Google Scholar
Miskowiak, K et al. (2017) Methodological recommendations for cognition trials in bipolar disorder by the international society for bipolar disorders targeting cognition task force. Bipolar Disorders 19, 614–626.Google Scholar
Miskowiak, K et al. (2018) Assessing and addressing cognitive impairment in bipolar disorder: the international society for bipolar disorders targeting cognition task force recommendations for clinicians. Bipolar Disorders. Jan 18. doi: 10.1111/bdi.12595. [Epub ahead of print].Google Scholar
O'Donnell, LA et al. (2017) Depression and executive functioning deficits predict poor occupational functioning in a large longitudinal sample with bipolar disorder. Journal of Affective Disorders 215, 135–142.Google Scholar
Palmer, BW et al. (1997) Is it possible to be schizophrenic yet neuropsychologically normal? Neuropsychology 11, 437.Google Scholar
Poitrenaud, J et al. (2007) Adaptation en langue française du California Verbal Learning Test. Paris: Les Editions du Centre de Psychologie Appliquée.Google Scholar
Reichenberg, A et al. (2009) Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophrenia Bulletin 35, 1022–1029.Google Scholar
Reitan, RM (1958) Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills 8, 271–276.Google Scholar
Rosa, AR et al. (2007) Validity and reliability of the functioning assessment short test (FAST) in bipolar disorder. Clinical Practice and Epidemiology in Mental Health 3, 5.Google Scholar
Roux, P et al. (2017 a) Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort. The British Journal of Psychiatry 211, 381–387.Google Scholar
Roux, P et al. (2017 b) Cognitive profiles in euthymic patients with bipolar disorders: results from the. Bipolar Disorders 19, 146–153.Google Scholar
Spielberger, CD and Sydeman, SJ (1994) State-trait anxiety inventory and state-trait anger expression inventory. In Maruish, ME (ed.), The Use of Psychological Testing for Treatment Planning and Outcome Assessment. Hillsdale, NJ: Lawrence Erlbaum Associates, Inc., pp. 292–321.Google Scholar
Torres, I et al. (2017) Are patients with bipolar disorder and comorbid attention-deficit hyperactivity disorder more neurocognitively impaired? Bipolar Disorders 19, 637–650.Google Scholar
Van Rheenen, TE et al. (2017) Characterizing cognitive heterogeneity on the schizophrenia–bipolar disorder spectrum. Psychological Medicine 47, 1848–1864.Google Scholar
Volkert, J et al. (2015) Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology 25, 192–202.Google Scholar
Wechsler, D (1997) WAIS III: Echelle d’intelligence pour adultes. Paris, France: Les éditions du Centre de Psychologie appliquée (ECPA).Google Scholar
Wechsler, D (2001) Echelle de mémoire de Wechsler MEM III. Paris: Les éditions du Centre de Psychologie appliquée.Google Scholar
Yatham, LN et al. (2010) The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disorders 12, 351–363.Google Scholar
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