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Patient's therapeutic skill acquisition and response to psychotherapy, alone or in combination with medication

Published online by Cambridge University Press:  13 May 2003

R. MANBER ,
B. ARNOW ,
C. BLASEY ,
D. VIVIAN ,
J. P. McCULLOUGH ,
J. A. BLALOCK ,
D. N. KLEIN ,
J. C. MARKOWITZ ,
L. P. RISO  and
B. ROTHBAUM
...Show all authors
R. MANBER
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
B. ARNOW
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
C. BLASEY
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
D. VIVIAN
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
J. P. McCULLOUGH
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
J. A. BLALOCK
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
D. N. KLEIN
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
J. C. MARKOWITZ
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
L. P. RISO
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
B. ROTHBAUM
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
A. J. RUSH
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
M. E. THASE
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
M. B. KELLER
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA; Department of Psychology, State University of New York at Stony Brook and Department of Psychiatry Cornell University Medical College, New York, NY; Department of Psychology, Virginia Commonwealth University, Richmond, VA; M. D. Anderson Cancer Center, Houston and University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Department of Psychology, Georgia State University, Atlanta, and Department of Psychiatry, Emory University School of Medicine, GA; Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinics, Pittsburgh, PA; and Department of Psychiatry, Brown University, Providence, RI, USA
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Abstract

Background. We tested the hypotheses that the addition of medication to psychotherapy enhances participation in the latter by: (1) speeding the acquisition of the psychotherapy's targeted skill; and (2) facilitating higher skill level acquisition.

Method. Participants were 431 chronically depressed patients who received Cognitive Behavioral Analysis System of Psychotherapy (CBASP), alone (N=214) or in combination with nefazodone (N=217), as part of a randomized chronic depression study (Keller et al. 2000). CBASP, developed specifically to treat chronic depression, uses a specific procedure, ‘situational analysis’ to help patients engage in more effective goal-oriented interpersonal behaviours. At the end of each session, therapists rated patients on their performance of situational analysis. Outcome on depressive symptoms was assessed with the 24-item Hamilton Rating Scale for Depression.

Results. Although reductions in depression were significantly greater in combined treatment compared to CBASP alone, there were no between-group differences in either the rate of skill acquisition or overall skill level at the end of treatment. Proficiency in the use of the main skill taught in psychotherapy at treatment midpoint predicted outcome independently of medication status and of baseline depressive severity.

Conclusions. Effective participation in CBASP, as reflected by proficiency in the compensatory skill taught in psychotherapy, is not enhanced by the addition of medication and does not mediate the between-group difference in depression outcome.

Type
Research Article
Information
Psychological Medicine , Volume 33 , Issue 4 , May 2003 , pp. 693 - 702
Copyright
© 2003 Cambridge University Press

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