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Paternal age at childbirth and eating disorders in offspring

Published online by Cambridge University Press:  03 November 2016

K. N. Javaras ,
M. E. Rickert ,
L. M. Thornton ,
C. M. Peat ,
J. H. Baker ,
A. Birgegård ,
C. Norring ,
M. Landén ,
C. Almqvist  and
H. Larsson
...Show all authors
K. N. Javaras
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
M. E. Rickert
Affiliation:
Department of Psychological and Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USA
L. M. Thornton
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
C. M. Peat
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA Department of Neurosurgery, University of North Carolina, Chapel Hill, NC, USA
J. H. Baker
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
A. Birgegård
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
C. Norring
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
M. Landén
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
C. Almqvist
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
H. Larsson
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
P. Lichtenstein
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
C. M. Bulik*
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA
B. M. D'Onofrio
Affiliation:
Department of Psychological and Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USA
*
*Address for correspondence: C. M. Bulik, Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive CB #7160, Chapel Hill, NC 27599-7160, USA. (Email: [email protected])
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Abstract

Background

Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence.

Method

Data for 2 276 809 individuals born in Sweden 1979–2001 were extracted from Swedish population and healthcare registers. The authors used Cox proportional hazards models to examine the effect of paternal age on the first incidence of healthcare-recorded anorexia nervosa (AN) and all eating disorders (AED) occurring 1987–2009. Models were adjusted for sex, birth order, maternal age at childbirth, and maternal and paternal covariates including country of birth, highest education level, and lifetime psychiatric and criminal history.

Results

Even after adjustment for covariates including maternal age, advanced paternal age was associated with increased risk, and younger paternal age with decreased risk, of AN and AED. For example, the fully adjusted hazard ratio for the 45+ years (v. the 25–29 years) paternal age category was 1.32 [95% confidence interval (CI) 1.14–1.53] for AN and 1.26 (95% CI 1.13–1.40) for AED.

Conclusions

In this large, population-based cohort, paternal age at childbirth was positively associated with eating disorders in offspring, even after adjustment for potential confounders. Future research should further explore potential explanations for the association, including de novo mutations in the paternal germline.

Keywords

Anorexia nervosaeating disorderspaternal age.
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 3 , February 2017 , pp. 576 - 584
Copyright
Copyright © Cambridge University Press 2016 

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References

Akaike, H (1974). A new look at the statistical model identification. Automatic Control, IEEE Transactions 19, 716–723.Google Scholar
Allen, KL, Byrne, SM, Forbes, D, Oddy, WH (2009). Risk factors for full- and partial-syndrome early adolescent eating disorders: a population-based pregnancy cohort study. Journal of the American Academy of Child and Adolescent Psychiatry 48, 800–809.Google Scholar
American Psychiatric Association (2013). DSM-5: Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Press: Washington, DC.Google Scholar
Birgegård, A, Björck, C, Clinton, D (2010). Quality assurance of specialised treatment of eating disorders using large-scale Internet-based collection systems: methods, results and lessons learned from designing the Stepwise database. European Eating Disorders Review 18, 251–259.Google Scholar
Buizer-Voskamp, JE, Laan, W, Staal, WG, Hennekam, EA, Aukes, MF, Termorshuizen, F, Kahn, RS, Boks, MP, Ophoff, RA (2011). Paternal age and psychiatric disorders: findings from a Dutch population registry. Schizophrenia Research 129, 128–132.Google Scholar
D'Onofrio, BM, Class, QA, Rickert, ME, Larsson, H, Långström, N, Lichtenstein, P (2013 a). Preterm birth and mortality and morbidity: a population-based quasi-experimental study. JAMA Psychiatry 70, 1231–1240.Google Scholar
D'Onofrio, BM, Lahey, BB, Turkheimer, E, Lichtenstein, P (2013 b). Critical need for family-based, quasi-experimental designs in integrating genetic and social science research. American Journal of Public Health 103, S46–S55.Google Scholar
D'Onofrio, BM, Rickert, ME, Frans, E, Kuja-Halkola, R, Almqvist, C, Sjölander, A, Larsson, H, Lichtenstein, P (2014). Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry 71, 432–438.Google Scholar
Fairburn, CG, Cooper, Z, Shafran, R (2003). Cognitive behaviour therapy for eating disorders: a ‘transdiagnostic’ theory and treatment. Behaviour Research and Therapy 41, 509–528.Google Scholar
Feighner, JP, Robins, E, Guze, SB, Woodruff, RA Jr., Winokur, G, Munoz, R (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 57–63.Google Scholar
Frans, EM, Sandin, S, Reichenberg, A, Lichtenstein, P, Langstrom, N, Hultman, CM (2008). Advancing paternal age and bipolar disorder. Archives of General Psychiatry 65, 1034–1040.CrossRefGoogle ScholarPubMed
Gratten, J, Wray, NR, Peyrot, WJ, McGrath, JJ, Visscher, PM, Goddard, ME (2016). Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations. Nature Genetics 48, 718–724.Google Scholar
Halmi, KA (1974). Anorexia nervosa: demographic and clinical features in 94 cases. Psychosomatic Medicine 36, 18–26.Google Scholar
Hernán, MA, Hernández-Díaz, S, Robins, JM (2004). A structural approach to selection bias. Epidemiology 15, 615–625.CrossRefGoogle ScholarPubMed
Hudson, JI, Javaras, KN, Laird, NM, VanderWeele, TJ, Pope, HG, Hernan, MA (2008). A structural approach to the familial coaggregation of disorders. Epidemiology 19, 431–439.CrossRefGoogle Scholar
Hultman, CM, Sandin, S, Levine, SZ, Lichtenstein, P, Reichenberg, A (2011). Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies. Molecular Psychiatry 16, 1203–1212.Google Scholar
Jaffe, AE, Eaton, WW, Straub, RE, Marenco, S, Weinberger, DR (2014). Paternal age, de novo mutations and schizophrenia. Molecular Psychiatry 19, 274–275.CrossRefGoogle ScholarPubMed
Javaras, KN, Runfola, CD, Thornton, LM, Agerbo, E, Birgegård, A, Norring, C, Yao, S, Råstam, M, Larsson, H, Lichtenstein, P, Bulik, CM (2015). Sex- and age-specific incidence of healthcare-register-recorded eating disorders in the complete Swedish 1979–2001 birth cohort: incidence of eating disorders. International Journal of Eating Disorders 48, 1070–1081.Google Scholar
Kong, A, Frigge, ML, Masson, G, Besenbacher, S, Sulem, P, Magnusson, G, Gudjonsson, SA, Sigurdsson, A, Jonasdottir, A, Jonasdottir, A, Wong, WSW, Sigurdsson, G, Walters, GB, Steinberg, S, Helgason, H, Thorleifsson, G, Gudbjartsson, DF, Helgason, A, Magnusson, OT, Thorsteinsdottir, U, Stefansson, K (2012). Rate of de novo mutations and the importance of father's age to disease risk. Nature 488, 471–475.Google Scholar
Laursen, TM, Munk-Olsen, T (2010). Reproductive patterns in psychotic patients. Schizophrenia Research 121, 234–240.Google Scholar
Malaspina, D, Harlap, S, Fennig, S, Heiman, D, Nahon, D, Feldman, D, Susser, ES (2001). Advancing paternal age and the risk of schizophrenia. Archives of General Psychiatry 58, 361–367.Google Scholar
McGrath, JJ, Petersen, L, Agerbo, E, Mors, O, Mortensen, PB, Pedersen, CB (2014). A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry 71, 301–309.Google Scholar
Menezes, PR, Lewis, G, Rasmussen, F, Zammit, S, Sipos, A, Harrison, GL, Tynelius, P, Gunnell, D (2010). Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring. Psychological Medicine 40, 477–485.CrossRefGoogle ScholarPubMed
Mustelin, L, Thornton, L, Keski-Rahkonen, A, Cantor-Graae, E, Mortensen, PB, Pedersen, C, Bulik, C (2016). Incidence of eating disorders in immigrant populations in Denmark. Oral presentation from the International Conference on Eating Disorders, San Francisco, CA, 2016.Google Scholar
Petersen, L, Mortensen, PB, Pedersen, CB (2011). Paternal age at birth of first child and risk of schizophrenia. American Journal of Psychiatry 168, 82–88.Google Scholar
Racine, SE, Culbert, KM, Burt, SA, Klump, KL (2014). Advanced paternal age at birth: phenotypic and etiologic associations with eating pathology in offspring. Psychological Medicine 44, 1029–1041.Google Scholar
Rahbar, MH, Samms-Vaughan, M, Loveland, KA, Pearson, DA, Bressler, J, Chen, Z, Ardjomand-Hessabi, M, Shakespeare-Pellington, S, Grove, ML, Beecher, C, Bloom, K, Boerwinkle, E (2012). Maternal and paternal age are jointly associated with childhood autism in Jamaica. Journal of Autism and Developmental Disorders 42, 1928–1938.CrossRefGoogle ScholarPubMed
Ronemus, M, Iossifov, I, Levy, D, Wigler, M (2014). The role of de novo mutations in the genetics of autism spectrum disorders. Nature Reviews Genetics 15, 133–141.Google Scholar
Runfola, CD, Thornton, LM, Pisetsky, EM, Bulik, CM, Birgegård, A (2014). Self-image and suicide in a Swedish national eating disorders clinical register. Comprehensive Psychiatry 55, 439–449.Google Scholar
Rutter, M (2007). Proceeding from observed correlation to causal inference: the use of natural experiments. Perspectives on Psychological Science 2, 377–395.Google Scholar
Schmidt, L, Sobotka, T, Bentzen, JG, Nyboe Andersen, A, on behalf of the ESHRE Reproduction and Society Task Force (2012). Demographic and medical consequences of the postponement of parenthood. Human Reproduction Update 18, 29–43.CrossRefGoogle ScholarPubMed
Smith, AL, Brandt, MD, Jimerson, DC (1989). Psychiatric disorders in the first-degree relatives of probands with bulimia nervosa. American Journal of Psychiatry 146, 1468–1471.Google Scholar
Striegel-Moore, RH, Bulik, CM (2007). Risk factors for eating disorders. American Psychologist 62, 181–198.Google Scholar
Swedish Association of Local Authorities and Regions (2007). National Healthcare Quality Registeries in Sweden. Swedish Association of Local Authorities and Regions: Stockholm, Sweden.Google Scholar
World Health Organization (1978). International Classification of Diseases, 9th revised edn. WHO: Geneva.Google Scholar
World Health Organization (1992). International Classification of Diseases, 10th revised edn. WHO: Geneva.Google Scholar
Yao, S, Kuja-Halkola, R, Thornton, LM, Birgegård, A, Norring, C, Bulik, CM, Larsson, H (2016). Exploring the association between eating disorders and crime using Swedish population data. Poster presentation from the International Conference on Eating Disorders, San Francisco, CA, 2016.Google Scholar
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