Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-26T07:59:55.214Z Has data issue: false hasContentIssue false
  • English
  • Français

P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

Published online by Cambridge University Press:  15 November 2013

K. C. Chen ,
I. H. Lee ,
Y. K. Yang ,
S. Landau ,
W. H. Chang ,
P. S. Chen ,
R. B. Lu ,
A. S. David  and
E. Bramon
K. C. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
I. H. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Y. K. Yang*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
S. Landau
Affiliation:
Department of Biostatistics, Institute of Psychiatry, King's College London, UK
W. H. Chang
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan
P. S. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
R. B. Lu
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
A. S. David
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
E. Bramon
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK Department of Biological Psychiatry, Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, UK
*
* Address for correspondence: Y. K. Yang, M.D., Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North Dist., Tainan 70403, Taiwan. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Reduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.

Method

We explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.

Results

No overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.

Conclusions

Our findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

Keywords

Dopamine transporterERPmedication-naive schizophreniameta-analysisP300 waveformsingle photon emission computerized tomography
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 10 , July 2014 , pp. 2151 - 2162
Copyright
Copyright © Cambridge University Press 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Araki, T, Kasai, K, Kirihara, K, Yamasue, H, Kato, N, Kudo, N, Nakagome, K, Iwanami, A (2006). Auditory P300 latency prolongation with age in schizophrenia: gender and subcomponent effects. Schizophrenia Research 88, 217–221.Google Scholar
Azizian, A, Polich, J (2007). Evidence for attentional gradient in the serial position memory curve from event-related potentials. Journal of Cognitive Neuroscience 19, 2071–2081.Google Scholar
Bledowski, C, Prvulovic, D, Goebel, R, Zanella, FE, Linden, DE (2004). Attentional systems in target and distractor processing: a combined ERP and fMRI study. NeuroImage 22, 530–540.Google Scholar
Bramon, E, Dempster, E, Frangou, S, McDonald, C, Schoenberg, P, MacCabe, JH, Walshe, M, Sham, P, Collier, D, Murray, RM (2006). Is there an association between the COMT gene and P300 endophenotypes? European Psychiatry 21, 70–73.CrossRefGoogle ScholarPubMed
Bramon, E, McDonald, C, Croft, RJ, Landau, S, Filbey, F, Gruzelier, JH, Sham, PC, Frangou, S, Murray, RM (2005). Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study. NeuroImage 27, 960–968.Google Scholar
Bramon, E, Rabe-Hesketh, S, Sham, P, Murray, RM, Frangou, S (2004). Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophrenia Research 70, 315–329.Google Scholar
Bramon, E, Shaikh, M, Broome, M, Lappin, J, Berge, D, Day, F, Woolley, J, Tabraham, P, Madre, M, Johns, L, Howes, O, Valmaggia, L, Perez, V, Sham, P, Murray, RM, McGuire, P (2008). Abnormal P300 in people with high risk of developing psychosis. NeuroImage 41, 553–560.CrossRefGoogle ScholarPubMed
Chang, LT (1978). A method for attenuation correction in radionuclide computed tomography. IEEE Transactions on Nuclear Science 25, 638–642.Google Scholar
Chen, KC, Yang, YK, Howes, O, Lee, IH, Landau, S, Yeh, TL, Chiu, NT, Chen, PS, Lu, RB, David, AS, Bramon, E (2013). Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [(99 m)Tc]-TRODAT-1 and a meta-analysis. Schizophrenia Bulletin 39, 378–386.Google Scholar
Coburn, KL, Shillcutt, SD, Tucker, KA, Estes, KM, Brin, FB, Merai, P, Moore, NC (1998). P300 delay and attenuation in schizophrenia: reversal by neuroleptic medication. Biological Psychiatry 44, 466–474.Google Scholar
Cohen, J (1988). Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Inc.: Hillsdale, NJ.Google Scholar
Curran, T (2004). Effects of attention and confidence on the hypothesized ERP correlates of recollection and familiarity. Neuropsychologia 42, 1088–1106.Google Scholar
de Wilde, OM, Bour, LJ, Dingemans, PM, Koelman, JH, Boeree, T, Linszen, DH (2008). P300 deficits are present in young first-episode patients with schizophrenia and not in their healthy young siblings. Clinical Neurophysiology 119, 2721–2726.Google Scholar
Duncan, CC, Barry, RJ, Connolly, JF, Fischer, C, Michie, PT, Naatanen, R, Polich, J, Reinvang, I, Van Petten, C (2009). Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clinical Neurophysiology 120, 1883–1908.Google Scholar
Faraone, SV, Chen, WJ, Goldstein, JM, Tsuang, MT (1994). Gender differences in age at onset of schizophrenia. British Journal of Psychiatry 164, 625–629.Google Scholar
Ford, JM, Krystal, JH, Mathalon, DH (2007). Neural synchrony in schizophrenia: from networks to new treatments. Schizophrenia Bulletin 33, 848–852.Google Scholar
Ford, JM, White, PM, Csernansky, JG, Faustman, WO, Roth, WT, Pfefferbaum, A (1994). ERPs in schizophrenia: effects of antipsychotic medication. Biological Psychiatry 36, 153–170.Google Scholar
Frangou, S, Sharma, T, Alarcon, G, Sigmudsson, T, Takei, N, Binnie, C, Murray, RM (1997). The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophrenia Research 23, 45–53.Google Scholar
Friston, KJ, Frith, CD, Liddle, PF, Dolan, RJ, Lammertsma, AA, Frackowiak, RS (1990). The relationship between global and local changes in PET scans. Journal of Cerebral Blood Flow and Metabolism 10, 458–466.Google Scholar
Frodl-Bauch, T, Bottlender, R, Hegerl, U (1999). Neurochemical substrates and neuroanatomical generators of the event-related P300. Neuropsychobiology 40, 86–94.Google Scholar
Frommann, I, Brinkmeyer, J, Ruhrmann, S, Hack, E, Brockhaus-Dumke, A, Bechdolf, A, Wolwer, W, Klosterkotter, J, Maier, W, Wagner, M (2008). Auditory P300 in individuals clinically at risk for psychosis. International Journal of Psychophysiology 70, 192–205.Google Scholar
Fusar-Poli, P, Borgwardt, S, Bechdolf, A, Addington, J, Riecher-Rossler, A, Schultze-Lutter, F, Keshavan, M, Wood, S, Ruhrmann, S, Seidman, LJ, Valmaggia, L, Cannon, T, Velthorst, E, De Haan, L, Cornblatt, B, Bonoldi, I, Birchwood, M, McGlashan, T, Carpenter, W, McGorry, P, Klosterkotter, J, McGuire, P, Yung, A (2013 a). The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 70, 107–120.Google Scholar
Fusar-Poli, P, Yung, AR, McGorry, P, van Os, J (2013 b). Lessons learned from the psychosis high-risk state: towards a general staging model of prodromal intervention. Psychological Medicine. Published online: 18 February 2013 . doi: 10.1017/S0033291713000184.Google ScholarPubMed
Gilmore, R (1995). Evoked potentials in the elderly. Journal of Clinical Neurophysiology 12, 132–138.Google Scholar
Gonul, AS, Suer, C, Coburn, K, Ozesmi, C, Oguz, A, Yilmaz, A (2003). Effects of olanzapine on auditory P300 in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 27, 173–177.Google Scholar
Guy, W (1976). ECDEU Assessment Manual for Psychopharmacology, Revised Edition. US Department of Health, Education, and Welfare: Washington, DC.Google Scholar
Hirayasu, Y, Asato, N, Ohta, H, Hokama, H, Arakaki, H, Ogura, C (1998). Abnormalities of auditory event-related potentials in schizophrenia prior to treatment. Biological Psychiatry 43, 244–253.Google Scholar
Howes, OD, Kapur, S (2009). The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophrenia Bulletin 35, 549–562.Google Scholar
Hwang, WJ, Yao, WJ, Wey, SP, Ting, G (2004). Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson's disease. Journal of Nuclear Medicine 45, 207–213.Google Scholar
Jahshan, C, Wynn, JK, Green, MF (2013). Relationship between auditory processing and affective prosody in schizophrenia. Schizophrenia Research 143, 348–353.Google Scholar
Jasper, H (1958). Progress and problems in brain research. Journal of the Mount Sinai Hospital, New York 25, 244–253.Google Scholar
Jeon, YW, Polich, J (2003). Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 40, 684–701.Google Scholar
Kay, SR, Fiszbein, A, Opler, LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261–276.Google Scholar
Kellendonk, C, Simpson, EH, Polan, HJ, Malleret, G, Vronskaya, S, Winiger, V, Moore, H, Kandel, ER (2006). Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49, 603–615.Google Scholar
Kenemans, JL, Kahkonen, S (2011). How human electrophysiology informs psychopharmacology: from bottom-up driven processing to top-down control. Neuropsychopharmacology 36, 26–51.Google Scholar
Lee, IH, Yang, YK, Chen, PS, Huang, HC, Yeh, TL, Lu, RB, Chiu, NT, Yao, WJ, Lin, SH (2011). Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers – a two isotopes SPECT study. Psychopharmacology 214, 617–624.Google Scholar
Loughland, C, Draganic, D, McCabe, K, Richards, J, Nasir, A, Allen, J, Catts, S, Jablensky, A, Henskens, F, Michie, P, Mowry, B, Pantelis, C, Schall, U, Scott, R, Tooney, P, Carr, V (2010). Australian Schizophrenia Research Bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia. Australian and New Zealand Journal of Psychiatry 44, 1029–1035.Google Scholar
Mangalathu-Arumana, J, Beardsley, SA, Liebenthal, E (2012). Within-subject joint independent component analysis of simultaneous fMRI/ERP in an auditory oddball paradigm. NeuroImage 60, 2247–2257.Google Scholar
Mathalon, DH, Ford, JM, Pfefferbaum, A (2000 a). Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological Psychiatry 47, 434–449.CrossRefGoogle ScholarPubMed
Mathalon, DH, Ford, JM, Rosenbloom, M, Pfefferbaum, A (2000 b). P300 reduction and prolongation with illness duration in schizophrenia. Biological Psychiatry 47, 413–427.CrossRefGoogle ScholarPubMed
Molina, V, Munoz, F, Martin-Loeches, M, Casado, P, Hinojosa, JA, Iglesias, A (2004). Long-term olanzapine treatment and P300 parameters in schizophrenia. Neuropsychobiology 50, 182–188.Google Scholar
Nieuwenhuis, S, Aston-Jones, G, Cohen, JD (2005). Decision making, the P3, and the locus coeruleus-norepinephrine system. Psychological Bulletin 131, 510–532.Google Scholar
O'Donnell, BF, Faux, SF, McCarley, RW, Kimble, MO, Salisbury, DF, Nestor, PG, Kikinis, R, Jolesz, FA, Shenton, ME (1995). Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process. Archives of General Psychiatry 52, 544–549.Google Scholar
Ozgurdal, S, Gudlowski, Y, Witthaus, H, Kawohl, W, Uhl, I, Hauser, M, Gorynia, I, Gallinat, J, Heinze, M, Heinz, A, Juckel, G (2008). Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia. Schizophrenia Research 105, 272–278.Google Scholar
Peters, Y, Barnhardt, NE, O'Donnell, P (2004). Prefrontal cortical up states are synchronized with ventral tegmental area activity. Synapse 52, 143–152.Google Scholar
Picton, TW (1992). The P300 wave of the human event-related potential. Journal of Clinical Neurophysiology 9, 456–479.Google Scholar
Pogarell, O, Padberg, F, Karch, S, Segmiller, F, Juckel, G, Mulert, C, Hegerl, U, Tatsch, K, Koch, W (2011). Dopaminergic mechanisms of target detection – P300 event related potential and striatal dopamine. Psychiatry Research 194, 212–218.Google Scholar
Polich, J (1998). P300 clinical utility and control of variability. Journal of Clinical Neurophysiology 15, 14–33.Google Scholar
Polich, J (2007). Updating P300: an integrative theory of P3a and P3b. Clinical Neurophysiology 118, 2128–2148.Google Scholar
Polich, J, Criado, JR (2006). Neuropsychology and neuropharmacology of P3a and P3b. International Journal of Psychophysiology 60, 172–185.Google Scholar
Schiff, S, Valenti, P, Andrea, P, Lot, M, Bisiacchi, P, Gatta, A, Amodio, P (2008). The effect of aging on auditory components of event-related brain potentials. Clinical Neurophysiology 119, 1795–1802.Google Scholar
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 (Suppl. 20), 22–33; quiz 34–57.Google Scholar
Shin, YW, Krishnan, G, Hetrick, WP, Brenner, CA, Shekhar, A, Malloy, FW, O'Donnell, BF (2010). Increased temporal variability of auditory event-related potentials in schizophrenia and schizotypal personality disorder. Schizophrenia Research 124, 110–118.Google Scholar
Takeshita, S, Ogura, C (1994). Effect of the dopamine D2 antagonist sulpiride on event-related potentials and its relation to the law of initial value. International Journal of Psychophysiology 16, 99–106.Google Scholar
van Beijsterveldt, CEM, van Baal, GCM (2002). Twin and family studies of the human electroencephalogram: a review and a meta-analysis. Biological Psychology 61, 111–138.Google Scholar
van der Stelt, O, Lieberman, JA, Belger, A (2005). Auditory P300 in high-risk, recent-onset and chronic schizophrenia. Schizophrenia Research 77, 309–320.Google Scholar
van Tricht, MJ, Nieman, DH, Koelman, JH, Bour, LJ, van der Meer, JN, van Amelsvoort, TA, Linszen, DH, de Haan, L (2011). Auditory ERP components before and after transition to a first psychotic episode. Biological Psychology 87, 350–357.Google Scholar
van Tricht, MJ, Nieman, DH, Koelman, JH, van der Meer, JN, Bour, LJ, de Haan, L, Linszen, DH (2010). Reduced parietal P300 amplitude is associated with an increased risk for a first psychotic episode. Biological Psychiatry 68, 642–648.Google Scholar
Wang, J, Hirayasu, Y, Hiramatsu, K, Hokama, H, Miyazato, H, Ogura, C (2003). Increased rate of P300 latency prolongation with age in drug-naive and first episode schizophrenia. Clinical Neurophysiology 114, 2029–2035.Google Scholar
Wang, J, Hirayasu, Y, Hokama, H, Tanaka, S, Kondo, T, Zhang, M, Xiao, Z (2005). Influence of duration of untreated psychosis on auditory P300 in drug-naive and first-episode schizophrenia. Psychiatry and Clinical Neurosciences 59, 209–214.Google Scholar
Wang, J, Tang, Y, Li, C, Mecklinger, A, Xiao, Z, Zhang, M, Hirayasu, Y, Hokama, H, Li, H (2010). Decreased P300 current source density in drug-naive first episode schizophrenics revealed by high density recording. International Journal of Psychophysiology 75, 249–257.Google Scholar
Xiong, P, Zeng, Y, Zhu, Z, Tan, D, Xu, F, Lu, J, Wan, J, Ma, M (2010). Reduced NGF serum levels and abnormal P300 event-related potential in first episode schizophrenia. Schizophrenia Research 119, 34–39.Google Scholar
Yu, YW, Chen, TJ, Chen, MC, Tsai, SJ, Lee, TW (2005). Effect of age and global function score on schizophrenic p300 characteristics. Neuropsychobiology 51, 45–52.Google Scholar
Yung, AR, Yuen, HP, McGorry, PD, Phillips, LJ, Kelly, D, Dell'Olio, M, Francey, SM, Cosgrave, EM, Killackey, E, Stanford, C, Godfrey, K, Buckby, J (2005). Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States. Australian and New Zealand Journal of Psychiatry 39, 964–971.Google Scholar