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Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family Studies

Published online by Cambridge University Press:  11 May 2012

L. J. Seidman ,
S. Cherkerzian ,
J. M. Goldstein ,
J. Agnew-Blais ,
M. T. Tsuang  and
S. L. Buka
L. J. Seidman*
Affiliation:
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA
S. Cherkerzian
Affiliation:
Department of Psychiatry, Harvard Medical School, Division of Women's Health, Connors Center for Women's Health and Gender Biology, Boston, MA, USA
J. M. Goldstein
Affiliation:
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Division of Women's Health, Connors Center for Women's Health and Gender Biology, Boston, MA, USA
J. Agnew-Blais
Affiliation:
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
M. T. Tsuang
Affiliation:
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA Department of Psychiatry, Center for Behavior Genomics and Institute of Genomic Medicine, University of CaliforniaSan Diego, La Jolla, CA, USA Veterans Medical Research Foundation, San Diego, CA, USA
S. L. Buka
Affiliation:
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA Department of Community Health, Brown University, Providence, RI, USA
*
*Address for correspondence: L. J. Seidman, Ph.D., Massachusetts Mental Health Center, Neuropsychology Laboratory, Commonwealth Research Center, 5th Floor, 75 Fenwood Road, Boston, MA 02115, USA. (Email: [email protected])
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Abstract

Background

Persons developing schizophrenia (SCZ) manifest various pre-morbid neuropsychological deficits, studied most often by measures of IQ. Far less is known about pre-morbid neuropsychological functioning in individuals who later develop bipolar psychoses (BP). We evaluated the specificity and impact of family history (FH) of psychosis on pre-morbid neuropsychological functioning.

Method

We conducted a nested case-control study investigating the associations of neuropsychological data collected systematically at age 7 years for 99 adults with psychotic diagnoses (including 45 SCZ and 35 BP) and 101 controls, drawn from the New England cohort of the Collaborative Perinatal Project (CPP). A mixed-model approach evaluated full-scale IQ, four neuropsychological factors derived from principal components analysis (PCA), and the profile of 10 intelligence and achievement tests, controlling for maternal education, race and intra-familial correlation. We used a deviant responder approach (<10th percentile) to calculate rates of impairment.

Results

There was a significant linear trend, with the SCZ group performing worst. The profile of childhood deficits for persons with SCZ did not differ significantly from BP. Neuropsychological impairment was identified in 42.2% of SCZ, 22.9% of BP and 7% of controls. The presence of psychosis in first-degree relatives (FH+) significantly increased the severity of childhood impairment for SCZ but not for BP.

Conclusions

Pre-morbid neuropsychological deficits are found in a substantial proportion of children who later develop SCZ, especially in the SCZ FH+ subgroup, but less so in BP, suggesting especially impaired neurodevelopment underlying cognition in pre-SCZ children. Future work should assess genetic and environmental factors that explain this FH effect.

Keywords

Bipolar psychosisneurocognitionpre-morbidschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 43 , Issue 1 , January 2013 , pp. 119 - 131
Copyright
Copyright © Cambridge University Press 2012

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References

Agnew-Blais, J, Seidman, LJ (in press). Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: a quantitative and qualitative review. Cognitive Neuropsychiatry.Google Scholar
APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn.American Psychiatric Association: Washington, DC.Google Scholar
Bearden, CE, Hoffman, KM, Cannon, TD (2001). The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disorders 3, 106–150.CrossRefGoogle ScholarPubMed
Bleuler, E (1950). Dementia Praecox or the Group of Schizophrenias. International Universities Press: New York, NY.Google Scholar
Boos, HB, Aleman, A, Cahn, W, Hulshoff Pol, H, Kahn, RS (2007). Brain volumes in relatives of patients with schizophrenia: a meta-analysis. Archives of General Psychiatry 64, 297–304.CrossRefGoogle ScholarPubMed
Bora, E, Yücel, M, Pantelis, C (2010 a). Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. Journal of Affective Disorders 127, 1–9.CrossRefGoogle ScholarPubMed
Bora, E, Yücel, M, Pantelis, C (2010 b). Cognitive impairment in affective psychoses: a meta-analysis. Schizophrenia Bulletin 36, 112–125.CrossRefGoogle ScholarPubMed
Bora, E, Yücel, M, Pantelis, C (2010 c). Cognitive impairment in schizophrenia and affective psychoses: implications for DSM-V and beyond. Schizophrenia Bulletin 36, 36–42.CrossRefGoogle ScholarPubMed
Buka, SL, Goldstein, JM, Seidman, LJ, Zornberg, GL, Donatelli, JA, Denny, LR, Tsuang, MT (1999). Impacts of perinatal hypoxia and genetic vulnerability on schizophrenia: the New England longitudinal studies of schizophrenia. Psychiatric Annals 29, 151–156.CrossRefGoogle Scholar
Cannon, M, Caspi, A, Moffitt, TE, Harrington, H, Taylor, A, Murray, RM, Poulton, R (2002). Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Archives of General Psychiatry 59, 449–456.CrossRefGoogle ScholarPubMed
Cannon, TD, Bearden, C, Hollister, JM, Rosso, IM, Sanchez, LE, Hadley, T (2000). Childhood cognitive functioning in schizophrenia patients and their unaffected siblings. Schizophrenia Bulletin 26, 379–393.CrossRefGoogle ScholarPubMed
Cornblatt, B, Obuchowski, M, Roberts, S, Pollack, S, Erlenmeyer-Kimling, L (1999). Cognitive and behavioral precursors of schizophrenia. Developmental Psychopathology 11, 487–508.CrossRefGoogle ScholarPubMed
Craddock, N, O'Donovan, MC, Owen, MJ (2006). Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32, 9–16.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M, Williams, JWB (1996). Structured Clinical Interview for DSM-IV Axis I Disorders – Patient Edition, Version 2. American Psychiatric Press: Washington, DC.Google Scholar
Glahn, DC, Bearden, CE, Barguil, M, Barrett, J, Reichenberg, A, Bowden, CL, Soares, JC, Velligan, DI (2007). The neurocognitive signature of psychotic bipolar disorder. Biological Psychiatry 62, 910–916.CrossRefGoogle ScholarPubMed
Goldstein, JM, Buka, SL, Seidman, LJ, Tsuang, MT (2010). Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design. Archives of General Psychiatry 67, 458–467.CrossRefGoogle ScholarPubMed
Goldstein, JM, Seidman, LJ, Buka, SL, Horton, N, Donatelli, J, Rieder, RO, Tsuang, MT (2000). Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychosis. Schizophrenia Bulletin 26, 323–334.CrossRefGoogle Scholar
Heinrichs, R, Zakzanis, K (1998). Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12, 426–445.CrossRefGoogle ScholarPubMed
Johnstone, EC, Ebmeier, KP, Miller, Owens, DG, Lawrie, SM (2005). Predicting schizophrenia: findings from the Edinburgh High-Risk Study. British Journal of Psychiatry 186, 18–25.CrossRefGoogle ScholarPubMed
Keshavan, MS, Kulkarni, SR, Bhojraj, T, Francis, A, Diwadkar, V, Montrose, DM, Seidman, L, Sweeney, J (2010). Premorbid cognitive deficits in young relatives of schizophrenia patients. Frontiers in Human Neuroscience 3, 1–14.Google ScholarPubMed
Kraepelin, E (1919). Dementia Praecox and Paraphrenia. E. & S. Livingstone: Edinburgh.Google Scholar
Lewandowski, KE, Cohen, BM, Öngur, D (2011). Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychological Medicine 41, 225–241.CrossRefGoogle ScholarPubMed
MacDonald, A, Thermenos, HW, Barch, D, Seidman, LJ (2009). Imaging genetic liability to schizophrenia: systematic review of fMRI studies of patients' nonpsychotic relatives. Schizophrenia Bulletin 35, 1142–1162.CrossRefGoogle ScholarPubMed
Maxwell, ME (1996). FIGS. Clinical Neurogenetics Branch, Intramural Research Program, NIMH: Bethesda, MD.Google Scholar
Mesholam-Gately, R, Giuliano, AJ, Faraone, SV, Goff, KP, Seidman, LJ (2009). Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 23, 315–336.CrossRefGoogle ScholarPubMed
Meyer, SE, Carlson, GA, Wiggs, EA, Martinez, PE, Ronsaville, DS, Klimes-Dougan, B, Gold, PW, Radke-Yarrow, M (2004). A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Developmental Psychopathology 16, 461–76.CrossRefGoogle ScholarPubMed
Murray, RM, Sham, P, van Os, J, Zanelli, J, Cannon, M, McDonald, C (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research 71, 405–416.CrossRefGoogle ScholarPubMed
Myrianthopoulos, NC, French, KS (1968). An application of the US Bureau of the Census socioeconomic index to a large, diversified patient population. Social Science and Medicine 2, 283–299.CrossRefGoogle ScholarPubMed
Niendam, T, Bearden, C, Rosso, I, Sanchez, LE, Hadley, T, Nuechterlein, KH, Cannon, TD (2003). A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. American Journal of Psychiatry 160, 2060–2062.CrossRefGoogle ScholarPubMed
Niswander, KR, Gordon, M (1972). The Women and their Pregnancies: The Collaborative Perinatal Study of the National Institute of Neurological Diseases and Stroke. U.S. Department of Health, Education, and Welfare; Government Printing Office: Washington, DC.Google Scholar
Ott, SL, Spinelli, S, Rock, D, Roberts, S, Amminger, GP, Erlenmeyer-Kimling, L (1998). The New York High-Risk Project: social and general intelligence in children at risk for schizophrenia. Schizophrenia Research 31, 1–11.CrossRefGoogle ScholarPubMed
Reichenberg, A, Caspi, A, Harrington, H, Houts, R, Keefe, RSE, Murray, RM, Poulton, R, Moffitt, TE (2010). Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study. American Journal of Psychiatry 167, 160–169.CrossRefGoogle ScholarPubMed
Reichenberg, A, Weiser, M, Rabinowitz, J, Caspi, A, Schmeidler, J, Mark, M, Kaplan, Z, Davidson, M (2002). A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder. American Journal of Psychiatry 159, 2027–35.CrossRefGoogle ScholarPubMed
Robins, LD, Helzer, TE, Cottler, L (1989). NIMH Diagnostic Interview Schedule, Version III-R. Washington University Medical School: St Louis, MO.Google Scholar
SAS (2008). SAS Software Version 9.2. SAS Institute Inc.: Cary, NC.Google Scholar
Seidman, LJ, Buka, SL, Goldstein, JM, Horton, N, Rieder, RO, Donatelli, J, Tsuang, MT (2000). The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project. Schizophrenia Bulletin 26, 309–321.CrossRefGoogle ScholarPubMed
Seidman, LJ, Buka, SL, Goldstein, JM, Tsuang, MT (2006). Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study. Journal of Clinical and Experimental Neuropsychology 28, 225–242.CrossRefGoogle ScholarPubMed
Seidman, LJ, Giuliano, AJ, Meyer, EC, Addington, J, Cadenhead, KS, Cannon, TD, McGlashan, TH, Perkins, DO, Tsuang, MT, Walker, EF, Woods, SW, Bearden, CE, Christensen, BK, Hawkins, K, Heaton, R, Keefe, RSE, Heinssen, R, Cornblatt, B (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Archives of General Psychiatry 67, 578–588.CrossRefGoogle ScholarPubMed
Seidman, LJ, Kremen, WS, Koren, D, Faraone, SV, Goldstein, JM, Tsuang, MT (2002). A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophrenia Research 53, 31–44.CrossRefGoogle ScholarPubMed
Tiihonen, J, Haukka, J, Henriksson, M, Cannon, M, Kieseppa, T, Laaksonen, I, Sinivuo, J, Lonnqvist, J (2005). Premorbid intellectual functioning in bipolar disorder and schizophrenia: results from a cohort study of male conscripts. American Journal of Psychiatry 162, 1904–1910.CrossRefGoogle ScholarPubMed
Urfer-Parnas, A, Mortensen, EL, Saebye, D, Parnas, J (2010). Pre-morbid IQ in mental disorders: a Danish draft-board study of 7486 psychiatric patients. Psychological Medicine 40, 547–556.CrossRefGoogle ScholarPubMed
Wechsler, D (1949). The Wechsler Intelligence Scale for Children. The Psychological Corporation: New York, NY.Google Scholar
Woodberry, K, Giuliano, AJ, Seidman, LJ (2008). Premorbid IQ in schizophrenia: a meta-analytic review. American Journal of Psychiatry 165, 579–587.CrossRefGoogle ScholarPubMed
Zammit, S, Allebeck, P, David, AS, Dalman, C, Hemmingsson, T, Lundberg, I, Lewis, G (2004). A longitudinal study of premorbid IQ score and risk of developing schizophrenia, bipolar disorder, severe depression and other nonaffective psychoses. Archives of General Psychiatry 61, 354–360.CrossRefGoogle ScholarPubMed
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