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Multicompartmental analysis of amino acids: III. Tyrosine in affective disorder

Published online by Cambridge University Press:  09 July 2009

D. M. Shaw ,
S. F. Tidmarsh ,
A. L. Johnson ,
A. C. Michalakeas ,
G. J. Riley ,
R. Blazek ,
D. A. MacSweeney ,
A. F. Francis  and
R. Hewland
D. M. Shaw*
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
S. F. Tidmarsh
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
A. L. Johnson
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
A. C. Michalakeas
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
G. J. Riley
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
R. Blazek
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
D. A. MacSweeney
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
A. F. Francis
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
R. Hewland
Affiliation:
Biochemical Psychiatry Laboratory, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff, and the MRC Statistical Research and Services Unit, University College Hospital Medical School, London
*
1Address for correspondence: Dr D. M. Shaw, Department of Psychological Medicine, Whitchurch Hospital, Cardiff CF4 7XB.
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Synopsis

Multicompartmental studies of tyrosine in patients suffering from affective disorders and controls gave estimates of 2 major pools of amino acid, together with the associated fractional clearance rates and fluxes. The 2 pools were considered provisionally to represent extracellular and intracellular tyrosine.

Type
Research Article
Information
Psychological Medicine , Volume 9 , Issue 1 , February 1979 , pp. 117 - 123
Copyright
Copyright © Cambridge University Press 1979

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References

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Riley, G. J. & Shaw, D. M. (1976). Total and non-bound tryptophan in unipolar illness. Lancet ii, 1249.CrossRefGoogle Scholar
Shaw, D. M., Tidmarsh, S. F., Johnson, A. L., Michalakeas, A. C., Riley, G. J., Blazek, R. & Francis, A. F. (1978). Multicompartmental analysis of amino acids. II. Tryptophan in affective disorder. Psychological Medicine 8, 487–494.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods, 6th edn, pp. 472–503. Iowa State University Press: Ames, Iowa.Google Scholar
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