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MRI in schizophrenia: basal ganglia and white matter T1 times

Published online by Cambridge University Press:  09 July 2009

I. Harvey ,
M. A. Ron ,
R. Murray ,
S. Lewis ,
G. Barker  and
D. McManus
I. Harvey
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
M. A. Ron*
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
R. Murray
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
S. Lewis
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
G. Barker
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
D. McManus
Affiliation:
Institute of Neurology; Institute of Psychiatry; and Charing Cross & Westminster Medical School, London
*
1 Address for correspondence: Dr M. A. Ron, Institute of Neurology, Queen Square, London WC1N 3BG.
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Synopsis

The T1 relaxation time of the basal ganglia (putamen, globus pallidus and head of caudate) and of the frontoparietal centrum semiovale was compared between 49 schizophrenic patients and 36 healthy controls. Previous reports of increased T1 time in the basal ganglia were not confirmed, and group differences were not detected within the white matter. Within patients T1 values could not be related to tardive dyskinesia or other clinical features. Normal variation seen in basal ganglia T1 times is described for the first time: lowest values occur in the globus pallidus and highest in the caudate, and values within the putamen increase rostrally.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 3 , August 1991 , pp. 587 - 598
Copyright
Copyright © Cambridge University Press 1991

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