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Lower prevalence of pre-morbid neurological illness in African-Caribbean than White psychotic patients in England

Published online by Cambridge University Press:  21 October 2002

K. McKENZIE ,
P. JONES ,
S. LEWIS ,
M. WILLIAMS ,
B. TOONE ,
P. SHAM  and
R. M. MURRAY
K. McKENZIE
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
P. JONES
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
S. LEWIS
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
M. WILLIAMS
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
B. TOONE
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
P. SHAM
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
R. M. MURRAY
Affiliation:
Department of Psychiatry and Behavioural Sciences, RFUC Medical School, Royal Free Campus, Department of Psychological Medicine, King's College Hospital and Division of Psychiatry, Institute of Psychiatry, London; University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge; and School of Psychiatry and Behavioural Sciences, University of Manchester, Withington Hospital, Manchester
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Abstract

Background. It has been suggested that the increased incidence of psychosis in African-Caribbeans living in England may be due to illnesses in which social stress plays an important aetiological role. If this is the case, the prevalence of factors associated with psychosis that predate illness onset such as obstetric complications, pre-morbid neurological illness and poor childhood social adjustment may be expected to be lower in African-Caribbean than Whites psychotic patients.

Method. Details of obstetric complications, pre-morbid neurological illness, and pre-morbid social adjustment were obtained for 337 psychotic patients by patient interview, interviews of mothers and chart review. The proportions of patients with each ‘risk factor’ in the African-Caribbean (N = 103) and White (N = 184) groups were compared using regression analysis; age, sex, social class, diagnosis and referral status were possible explanatory variables.

Results. African-Caribbean patients were less likely to have suffered a pre-morbid neurological disorder than their White counterparts (odds ratio 0.19, 95% CI 0.06–0.61). There was no significant difference in pre-morbid social adjustment or obstetric complications between the two groups, though fewer obstetric complications were reported in the African-Caribbean group (21.5%) than the White group (30.9%).

Conclusions. African-Caribbean patients with psychosis have experienced less pre-morbid neurological illness.

Type
Research Article
Information
Psychological Medicine , Volume 32 , Issue 7 , October 2002 , pp. 1285 - 1291
Copyright
© 2002 Cambridge University Press

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