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A longitudinal, population-based twin study of avoidant and obsessive-compulsive personality disorder traits from early to middle adulthood

Published online by Cambridge University Press:  14 August 2015

L. C. Gjerde ,
N. Czajkowski ,
E. Røysamb ,
E. Ystrom ,
K. Tambs ,
S. H. Aggen ,
R. E. Ørstavik ,
K. S. Kendler ,
T. Reichborn-Kjennerud  and
G. P. Knudsen
L. C. Gjerde*
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
N. Czajkowski
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
E. Røysamb
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
E. Ystrom
Affiliation:
Department of Psychology, University of Oslo, Oslo, Norway
K. Tambs
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
S. H. Aggen
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA, USA
R. E. Ørstavik
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
K. S. Kendler
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA, USA Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
T. Reichborn-Kjennerud
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Institute of Psychiatry, University of Oslo, Oslo, Norway Department of Epidemiology, Columbia University, New York, NY, USA
G. P. Knudsen
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
*
* Address for correspondence: Dr L. C. Gjerde, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway (Email: [email protected])
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Abstract

Background.

The phenotypic stability of avoidant personality disorder (AVPD) and obsessive-compulsive personality disorder (OCPD) has previously been found to be moderate. However, little is known about the longitudinal structure of genetic and environmental factors for these disorders separately and jointly, and to what extent genetic and environmental factors contribute to their stability.

Method.

AVPD and OCPD criteria were assessed using the Structured Interview for DSM-IV Personality in 2793 young adult twins (1385 pairs, 23 singletons) from the Norwegian Institute of Public Health Twin Panel at wave 1 and 2282 (986 pairs, 310 singletons) of these on average 10 years later at wave 2. Longitudinal biometric models were fitted to AVPD and OCPD traits.

Results.

For twins who participated at both time-points, the number of endorsed sub-threshold criteria for both personality disorders (PDs) decreased 31% from wave 1 to wave 2. Phenotypic correlations between waves were 0.54 and 0.37 for AVPD and OCPD, respectively. The heritability estimates of the stable PD liabilities were 0.67 for AVPD and 0.53 for OCPD. The genetic correlations were 1.00 for AVPD and 0.72 for OCPD, while the unique environmental influences correlated 0.26 and 0.23, respectively. The correlation between the stable AVPD and OCPD liabilities was 0.39 of which 63% was attributable to genetic influences. Shared environmental factors did not significantly contribute to PD variance at either waves 1 or 2.

Conclusion.

Phenotypic stability was moderate for AVPD and OCPD traits, and genetic factors contributed more than unique environmental factors to the stability both within and across phenotypes.

Keywords

Avoidant personality disorder traitslongitudinal studiesNorwegian Twin Registryobsessive-compulsive personality traitstwin studies
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 16 , December 2015 , pp. 3539 - 3548
Copyright
Copyright © Cambridge University Press 2015 

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References

Akaike, H (1987). Factor analysis and AIC. Psychometrica 52, 317–332.CrossRefGoogle Scholar
APA (1980). Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC.Google Scholar
APA (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing: Washington, DC.Google Scholar
Bernstein, DP, Arntz, A, Travaglini, L (2014). Schizoid and avoidant personality disorders. In Oxford Textbook of Psychopathology (ed. Blaney, P.H., Krueger, R.F. and Millon, T.), pp. 639–658. Oxford University Press: New York, NY.Google Scholar
Boker, MS, Neale, MC, Maes, H, Wilde, M, Spiegel, M, Brick, T, Spies, J, Estabrook, R, Kenny, S, Bates, T, Mehta, P, Fox, J (2011). OpenMx: an open source extended structural equation modeling framework. Psychometrica 76, 306–317.CrossRefGoogle ScholarPubMed
Erol, RY, Orth, U (2011). Self-esteem development from age 14–30 years: a longitudinal study. Journal of Personality and Social Psychology 101, 607–619.CrossRefGoogle Scholar
Falconer, DS (1965). Inheritance of liability to certain diseases estimated from incidence among relatives. Annual of Human Genetics 29, 51–76.CrossRefGoogle Scholar
Fox, J (2010). polycor: Polychoric and polyserial correlations. R package version 0.7–8 (http://CRAN.R-project.org/package=polycor).Google Scholar
Gjerde, LC, Czajkowski, N, Roysamb, E, Orstavik, RE, Knudsen, GP, Ostby, K, Torgersen, S, Myers, J, Kendler, KS, Reichborn-Kjennerud, T (2012). The heritability of avoidant and dependent personality disorder assessed by personal interview and questionnaire. Acta Psychiatrica Scandinavica 126, 448–457.CrossRefGoogle ScholarPubMed
Grant, JE, Mooney, ME, Kushner, MG (2012). Prevalence, correlates, and comorbidity of DSM-IV obsessive-compulsive personality disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Psychiatric Research 46, 469–475.CrossRefGoogle ScholarPubMed
Grilo, CM, Sanislow, CA, Gunderson, JG, Pagano, ME, Yen, S, Zanarini, MC, Shea, MT, Skodol, AE, Stout, RL, Morey, LC, McGlashan, TH (2004). Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders. Journal of Consulting and Clinical Psychology 72, 767–775.CrossRefGoogle ScholarPubMed
Harris, JR, Magnus, P, Tambs, K (2006). The Norwegian Institute of Public Health twin program of research: an update. Twin Research and Human Genetics 9, 858–64.CrossRefGoogle ScholarPubMed
Heath, AC, Madden, PAF, Martin, NG (1998). Assessing the effects of cooperation bias and attrition in behavioral genetic research using data-weighting. Behavior Genetics 28, 415–427.CrossRefGoogle ScholarPubMed
Hopwood, CJ, Morey, LC, Donnellan, MB, Samuel, DB, Grilo, CM, McGlashan, TH, Shea, MT, Zanarini, MC, Gunderson, JG, Skodol, AE (2013). Ten-year rank-order stability of personality traits and disorders in a clinical sample. Journal of Personality 81, 335–344.CrossRefGoogle Scholar
Johnson, JG, Cohen, P, Kasen, S, Skodol, AE, Hamagami, F, Brook, JS (2000). Age-related change in personality disorder trait levels between early adolescence and adulthood: a community-based longitudinal investigation. Acta Psychiatrica Scandinavica 102, 265–275.CrossRefGoogle ScholarPubMed
Kendler, KS, Aggen, SH, Czajkowski, N, Roysamb, E, Tambs, K, Torgersen, S, Neale, MC, Reichborn-Kjennerud, T (2008). The structure of genetic and environmental risk factors for DSM-IV personality disorders a multivariate twin study. Archives of General Psychiatry 65, 1438–1446.CrossRefGoogle ScholarPubMed
Kendler, KS, Aggen, SH, Neale, MC, Knudsen, GP, Krueger, RF, Tambs, K, Czajkowski, N, Ystrom, E, Orstavik, RE, Reichborn-Kjennerud, T (2014). A longitudinal twin study of cluster A personality disorders. Psychological Medicine 14, 1–8.CrossRefGoogle Scholar
Kendler, KS, Czajkowski, N, Tambs, K, Torgersen, S, Aggen, SH, Neale, MC, Reichborn-Kjennerud, T (2006). Dimensional representations of DSM-IV Cluster A personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychological Medicine 36, 1583–1591.CrossRefGoogle Scholar
Kendler, KS, Myers, J, Torgersen, S, Neale, MC, Reichborn-Kjennerud, T (2007). The heritability of cluster A personality disorders assessed by both personal interview and questionnaire. Psychological Medicine 37, 655–665.CrossRefGoogle Scholar
Krueger, RF (2005). Continuity of axes I and II: toward a unified model of personality, personality disorders, and clinical disorders. Journal of Personality Disorders 19, 233–261.CrossRefGoogle Scholar
Krueger, RF, Derringer, J, Markon, KE, Watson, D, Skodol, AE (2012). Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychological Medicine 42, 1879–1890.CrossRefGoogle ScholarPubMed
Lenzenweger, MF (1999). Stability and change in personality disorder features – The longitudinal study of personality disorders. Archives of General Psychiatry 56, 1009–1015.CrossRefGoogle ScholarPubMed
Morey, LC, Hopwood, CJ (2013). Stability and Change in Personality Disorders. In Annual Review of Clinical Psychology, Vol 9 (ed. NolenHoeksema, S.), pp. 499–528. Annual Reviews: Palo Alto.Google Scholar
Nilsen, TS, Knudsen, GP, Gervin, K, Brandt, I, Roysamb, E, Tambs, K, Orstavik, R, Lyle, R, Reichborn-Kjennerud, T, Magnus, P, Harris, JR (2013). The Norwegian twin registry from a public health perspective: a research update. Twin Research and Human Genetics 16, 285–295.CrossRefGoogle ScholarPubMed
Pfohl, BB, Zimmerman, M (1995). Structured Interview for DSM-IV Personality (SIDP-IV) . University of Iowa, Department of Psychiatry: Iowa City.Google Scholar
R Development Core Team (2012). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria.Google Scholar
Reichborn-Kjennerud, T, Czajkowski, N, Neale, MC, Orstavik, RE, Torgersen, S, Tambs, K, Roysamb, E, Harris, JR, Kendler, KS (2007). Genetic and environmental influences on dimensional representations of DSM-IV cluster C personality disorders: a population-based multivariate twin study. Psychological Medicine 37, 645–653.CrossRefGoogle ScholarPubMed
Reichborn-Kjennerud, T, Knudsen, GP (2014). Obsessive-compulsive personality disorder. In Oxford Textbook of Psychopathology (ed. Blaney, P. H., Krueger, R. F. and Millon, T.), pp. 707–728. Oxford University Press: New York, NY.Google Scholar
Revelle, W (2013). psych: Procedures for Personality and Psychological Research. Version 1.3.10 (http://CRAN.R-project.org/package=psych). Northwestern University, Evanston, Illinois, USA.Google Scholar
Sanislow, CA, Little, TD, Ansell, EB, Grilo, CM, Daversa, M, Markowitz, JC, Pinto, A, Shea, MT, Yen, S, Skodol, AE, Morey, LC, Gunderson, JG, Zanarini, MC, McGlashan, TH (2009). Ten-year stability and latent structure of the DSM-IV schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders. Journal of Abnormal Psychology 118, 507–519.CrossRefGoogle ScholarPubMed
Skodol, AE, Gunderson, JG, Shea, MT, McGlashan, TH, Morey, LC, Sanislow, CA, Bender, DS, Grilo, CM, Zanarini, MC, Yen, S, Pagano, ME, Stout, RL (2005). The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications. Journal of Personality Disorders 19, 487–504.CrossRefGoogle Scholar
Soeteman, DI, Hakkaart-van Roijen, L, Verheul, R, Busschbach, JJV (2008). The economic burden of personality disorders in mental health care. Journal of Clinical Psychiatry 69, 259–265.CrossRefGoogle ScholarPubMed
Tambs, K, Ronning, T, Prescott, CA, Kendler, KS, Reichborn-Kjennerud, T, Torgersen, S, Harris, JR (2009). The Norwegian Institute of Public Health twin study of mental health: examining recruitment and attrition bias. Twin Research and Human Genetics 12, 158–168.CrossRefGoogle ScholarPubMed
Torgersen, S, Czajkowski, N, Jacobson, K, Reichborn-Kjennerud, T, Roysamb, E, Neale, MC, Kendler, KS (2008). Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychological Medicine 38, 1617–1625.CrossRefGoogle Scholar
Torgersen, S, Lygren, S, Oien, PA, Skre, I, Onstad, S, Edvardsen, J, Tambs, K, Kringlen, E (2000). A twin study of personality disorders. Comprehensive Psychiatry 41, 416–425.CrossRefGoogle ScholarPubMed
Torgersen, S, Myers, J, Reichborn-Kjennerud, T, Røysamb, E, Kubarych, T, Kendler, KS (2012). The heritability of Cluster B personality disorders assessed both by personal interview and questionnaire. Journal of Personality Disorders 26, 848–866.CrossRefGoogle ScholarPubMed
Zimmerman, M, Rothschild, L, Chelminski, I (2005). The prevalence of DSM-IV personality disorders in psychiatric outpatients. American Journal of Psychiatry 162, 1911–1918.CrossRefGoogle ScholarPubMed