Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-08T02:56:22.377Z Has data issue: false hasContentIssue false

Improvement in central monoamine metabolism in adult coeliac patients starting a gluten-free diet

Published online by Cambridge University Press:  09 July 2009

Claes Hallert*
Affiliation:
Department of Internal Medicine, Central Hospital, Växjö, and the Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden
Göran Sedvall
Affiliation:
Department of Internal Medicine, Central Hospital, Växjö, and the Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden
*
1Address for correspondence: Dr Claes Hallert, Department of Internal Medicine, Central Hospital, S-351 85 Växjö, Sweden.

Synopsis

Adult coeliac patients taking a gluten-free diet for one year showed an increase of 33% in the concentrations in CSF of major monoamine metabolites (5-HIAA, HVA and MOPEG). Tryptophan in CSF rose by 10%. There was concomitant morphological improvement in the jejunal mucosa, and the results would seem to indicate that the reduced central monoamine metabolism in untreated adult coeliacs is not primarily genetically determined but is probably related to the poor intestinal absorption.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Åsberg, M. & Bertilsson, L. (1979). Serotonin in depressive illness: studies of CSF 5-HIAA. In Neuro-psychopharmacology (ed. Saletu, B.), pp. 105115. Pergamon Press: Oxford and New York.CrossRefGoogle Scholar
Barry, R. E., Baker, P. & Read, A. E. (1974). Coeliac disease. The clinical presentation. Clinics in Gastroenterology 3, 5569.CrossRefGoogle ScholarPubMed
Beck, O. & Hesselgren, T. (1980). Method for the determination of tryptophan in serum and cerebrospinal fluid. Journal of Chromatography 181, 100102.CrossRefGoogle ScholarPubMed
Carlsson, A., Svennerholm, L. & Winblad, B. (1980) Seasonal and circadian monoamine variations in human brains examined post mortem. In Biogenic Amines and Affective Disorders (ed. Svensson, T. H. and Carlsson, A.), pp. 7583. Acta Psychiatrica Scandinavica 61, Supplement 280.Google Scholar
Challacombe, D. N., Dawkins, P. D. & Baker, P. (1977). Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease. Gut 18, 882886.CrossRefGoogle ScholarPubMed
Dohan, F. C. (1980). Hypothesis: genes and neuroactive peptides from food as cause of schizophrenia. In Neural Peptides and Neuronal Communications (ed. Costa, E. and Trabucci, M.), pp. 535548. Raven Press: New York.Google Scholar
Gál, E. M. & Sherman, A. D. (1980). L-kynurenine: its synthesis and possible regulatory function in brain. Neurochemical Research 5, 223239.Google Scholar
Goldberg, D. (1970). A psychiatric study of patients with diseases of the small intestine. Gut 11, 459465.Google Scholar
Green, A. R. & Curzon, G. (1970). The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism. Biochemical Pharmacology 19, 20612068.CrossRefGoogle ScholarPubMed
Hallert, C. (1982). Psychiatric illness, gluten and celiac disease. Journal of Biological Psychiatry 9, 959961.Google Scholar
Hallert, C. & Åström, J. (1982). Psychic disturbances in adult coeliac disease. II. Psychological findings. Scandinavian Journal of Gastroenterology 17, 2124.Google Scholar
Hallert, C. & Derefeldt, T. (1982). Psychic disturbances in adult coeliac disease. I. Clinical observations. Scandinavian Journal of Gastroenterology 17, 1719.Google Scholar
Hallert, C., Gotthard, R., Norrby, K. & Walan, A. (1981). On the prevalence of adult coeliac disease in Sweden. Scandinavian Journal of Gastroenterology 16, 257261.CrossRefGoogle ScholarPubMed
Hallert, C., Åström, J. & Sedvall, G. (1982 a). Psychic disturbances in adult coeliac disease. III. Reduced central monoamine metabolism and signs of depression. Scandinavian Journal of Gastroenterology 17, 2528.CrossRefGoogle ScholarPubMed
Hallert, C., Mårtensson, J. & Allgén, L.-G. (1982 b). Brain availability of monoamine precursors in adult coeliac disease. Scandinavian Journal of Gastroenterology 17, 8789.CrossRefGoogle ScholarPubMed
Hallert, C., Allenmark, S., Larsson-Cohn, U. & Sedvall, G. (1982 c). High level of pyridoxal 5-phosphate in cerebrospinal fluid of adult celiac patients. American Journal of Clinical Nutrition 36, 851854.Google Scholar
Hallert, C., Åström, J. & Walan, A. (1983). Reversal of psychopathology in adult coeliac disease with aid of pyridoxine (vitamin B4). Scandinavian Journal of Gastroenterology (in the press).CrossRefGoogle Scholar
Henriksson, K. G., Hallert, C., Norrby, K. & Walan, A. (1982). Polymyositis and adult coeliac disease. Acta Neurologica Scandinavica 65, 301319.Google Scholar
Kinney, H. C., Burger, P. C., Hurwitz, B. J., Hijmans, J. C. & Grant, J. P. (1982). Degeneration of the central nervous system associated with celiac disease. Journal of Neurological Science 53, 922.CrossRefGoogle ScholarPubMed
Kowlessar, O. D., Haeffner, L. J. & Benson, G. D. (1964). Abnormal tryptophan metabolism in patients with adult celiac disease with evidence for deficiency of vitamin B4. Journal of Clinical Investigation 43, 894903.CrossRefGoogle Scholar
Lancet (1976). Editorial: Gluten and schizophrenia; i, 844.CrossRefGoogle Scholar
Reinken, L. & Zieglauer, H. (1978). Vitamin B6 absorption in children with acute celiac disease and in control subjects. Journal of Nutrition 108, 15621565.Google Scholar
Sedvall, G., Fyrö, B., Gullberg, B., Nybäck, H., Wiesel, F-A. & Wode-Helgodt, B. (1980). Relationships in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity. British Journal of Psychiatry 136, 366374.CrossRefGoogle ScholarPubMed
Sourkes, T. L. (1979). Nutrients and the cofactors required for monoamine synthesis in nervous tissue. In Nutrition and the Brain, Vol.3 (ed. Wurtman, R. J. and Wurtman, J. J.), pp. 265299. Raven Press: New York.Google Scholar
Storms, L. H., Clopton, J. M. & Wright, C. (1982). Effects of gluten on schizophrenics. Archives of General Psychiatry 39, 323327.CrossRefGoogle ScholarPubMed
Swahn, C.-G., Sandgärde, B., Wiesel, F.-A. & Sedvall, G. (1976). Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method. Psychopharmacology 48, 147152.CrossRefGoogle Scholar
Swinson, C. M. & Levi, A. J. (1980). Is coeliac disease under-diagnosed? British Medical Journal 281, 12581260.Google Scholar
Wurtman, R. J. (1979). When and why should nutritional state control neurotransmitter synthesis? Journal of Neural Transmission Supplement 15, 6979.CrossRefGoogle Scholar