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The impact of childhood trauma on thalamic functional connectivity in patients with obsessive–compulsive disorder

Published online by Cambridge University Press:  20 November 2020

Minyi Chu ,
Tingting Xu ,
Yi Wang ,
Pei Wang ,
Qiumeng Gu ,
Qiang Liu ,
Eric F. C. Cheung ,
Raymond C. K. Chan Open the ORCID record for Raymond C. K. Chan [Opens in a new window]  and
Zhen Wang Open the ORCID record for Zhen Wang [Opens in a new window]
Minyi Chu
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Tingting Xu
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yi Wang
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Pei Wang
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qiumeng Gu
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qiang Liu
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Eric F. C. Cheung
Affiliation:
Castle Peak Hospital, Hong Kong Special Administration Region, China
Raymond C. K. Chan*
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China Neuropsychology and Applied Cognitive Neuroscience, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Zhen Wang
Affiliation:
Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China Institute of Psychological and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China
*
Author for correspondence: Zhen Wang, E-mail: [email protected]; Raymond C. K. Chan, E-mail: [email protected]
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Abstract

Background

Childhood trauma is a vulnerability factor for the development of obsessive–compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients.

Methods

Magnetic resonance imaging resting-state scans were acquired in 79 patients with OCD, including 22 patients with a high level of childhood trauma (OCD_HCT), 57 patients with a low level of childhood trauma (OCD_LCT) and 47 healthy controls. Seven thalamic subdivisions were chosen as regions of interest (ROIs) to examine the group difference in thalamic ROIs and whole-brain resting-state functional connectivity (rsFC).

Results

We found significantly decreased caudate-thalamic rsFC in OCD patients as a whole group and also in OCD_LCT patients, compared with healthy controls. However, OCD_HCT patients exhibited increased thalamic rsFC with the prefrontal cortex when compared with both OCD_LCT patients and healthy controls.

Conclusions

Taken together, OCD patients with high and low levels of childhood trauma exhibit different pathological alterations in thalamic rsFC, suggesting that childhood trauma may be a predisposing factor for some OCD patients.

Keywords

Caudatechildhood traumacluster analysisobsessive–compulsive disorderresting-state functional connectivitythalamus
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 13 , October 2022 , pp. 2471 - 2480
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press.

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Footnotes

*

These authors contributed equally to the study.

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