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Immunological variability associated with experimentally-induced positive and negative affective states

Published online by Cambridge University Press:  09 July 2009

Ann D. Futterman ,
Margaret E. Kemeny ,
David Shapiro ,
William Polonsky  and
John L. Fahey
Ann D. Futterman*
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
Margaret E. Kemeny
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
David Shapiro
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
William Polonsky
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
John L. Fahey
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
*
1 Address for correspondence: Dr Ann D. Futterman, Department of Rehabilitation Medicine, University of Colorado Health Sciences Center, Campus Box E243, 4701 East Ninth Avenue, Denver, Colorado 80262, USA.
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Synopsis

Functional and phenotypic immunological parameters were examined immediately before, after, and 30 minutes after experimentally-induced short-term positive (happiness) and negative (anxiety, depression) affective states and a neutral state, in five healthy subjects. Results indicated that all affective states induced more immune fluctuations (regardless of the direction) than the neutral state. Furthermore, among the affective states, anxiety induced the most immunological variability and depression the least.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 22 , Issue 1 , February 1992 , pp. 231 - 238
Copyright
Copyright © Cambridge University Press 1992

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