Hostname: page-component-745bb68f8f-v2bm5 Total loading time: 0 Render date: 2025-01-26T01:45:55.952Z Has data issue: false hasContentIssue false
  • English
  • Français

Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia

Published online by Cambridge University Press:  09 July 2009

S. L. Morrison-Stewart ,
P. C. Williamson ,
W. C. Corning ,
S. P. Kutcher ,
W. G. Snow  and
H. Merskey
S. L. Morrison-Stewart*
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
P. C. Williamson
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
W. C. Corning
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
S. P. Kutcher
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
W. G. Snow
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
H. Merskey
Affiliation:
EEG Department, London Psychiatric Hospital, London, Ontario, Canada
*
1Address for correspondence: Dr S. L. Morrison-Stewart, EEG Department, London Psychiatric Hospital, 850 Highbury Avenue, PO Box 2532, London, Ontario, Canada N6A 4H1.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Schizophrenic subjects performed significantly worse on neuropsychological tests of frontal lobe function but not on tests of non-frontal lobe function when compared to a matched group of normal subjects. Correlations expected between frontal lobe neuropsychological test performance and negative symptoms were not found.

Type
Original Articles
Information
Psychological Medicine , Volume 22 , Issue 2 , May 1992 , pp. 353 - 359
Copyright
Copyright © Cambridge University Press 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, N. (1984 a). Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa: Iowa City.Google Scholar
Andreasen, N. (1984 b). Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa: Iowa City.Google Scholar
Benson, D. F. & Zaidel, E. (eds). (1985). The Duel Brain Hemispheric Specialization in Humans. Guilford: New York.Google Scholar
Benton, A. (1963). The Revised Retention Test: Clinical and Experimental Applications. Psychological Corporation: New York.Google Scholar
Berman, K., Zec, R. & Weinberger, D. (1986). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention and mental effort. Archives of General Psychiatry 43, 126–135.CrossRefGoogle ScholarPubMed
Berman, K., Illowsky, B. & Weinberger, D. (1988). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. Archives of General Psychiatry 45, 616–622.CrossRefGoogle ScholarPubMed
Bornstein, R. A., Nasrallah, H. A., Olsen, S. C., Coffman, J. A., Torello, M. & Schwarzkopf, S. (1990). Neuropsychological deficit in schizophrenic subtypes: Paranoid, nonparanoid and schizo-affective subgroups. Psychiatry Research 31, 15–24.CrossRefGoogle Scholar
Bryden, P. (1977). Measuring handedness with questionnaires. Neuropsychologia 15, 617–624.CrossRefGoogle ScholarPubMed
Buchsbaum, M. & Haier, R. (1987). Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin 13, 115–132.CrossRefGoogle ScholarPubMed
Buchsbaum, M. & Hazlett, E. (1989). Relative metabolic rate in frontal lobes of normals and schizophrenics assessed by positron emission tomography. In Schizophrenia: Scientific Progress (ed. Schulz, C. and Tamminga, C.), pp. 247–259. Oxford University Press: New York.Google Scholar
Buchsbaum, M., Ingvar, D., Kessler, R., Waters, R., Cappelletti, J., van Kammen, D., King, C., Johnson, J., Manning, R., Flynn, R., Mann, L., Bunney, W. & Sokoloff, L. (1982). Cerebral glucography with positron emission tomography: use in normal subjects and in patients with schizophrenia. Archives of General Psychiatry 39, 251–259.CrossRefGoogle ScholarPubMed
Cohen, R., Semple, W., Gross, M., Nordahl, T., DeLisi, L., Holcomb, H., King, A., Morihisa, J. & Pickar, D. (1987). Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences 40, 2031–2039.CrossRefGoogle Scholar
Cooley, W. & Lohnes, P. (1962). Multivariate Procedures for the Behavioral Sciences. Wiley: New York.Google Scholar
Dodrill, C. B. (1981). An economical method for the evaluation of general intelligence in adults. Journal of Consulting and Clinical Psychology 49, 668–673.CrossRefGoogle ScholarPubMed
Goldberg, E. (1985). Akinesia, tardive dysmentia and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 11, 255–263.CrossRefGoogle ScholarPubMed
Gruzelier, J., Seymour, K., Wilson, L., Haynes, R., Jolley, T., Flynn, M. & Hirsch, S. (1987). Neuropsychological evidence of hippocampal and frontal impairments in schizophrenia, mania and depression. In Cerebral Dynamics, Laterality and Psychopathology (ed. Takahashi, R., Flor-Henry, P., Gruzelier, J. and Niwa, S.), pp. 273–286. Elsevier Science Publishers: Amsterdam.Google Scholar
Gruzelier, J., Seymour, K., Wilson, L., Jolly, A. & Hirsch, S. (1988). Impairments on neuropsychological tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623–629.CrossRefGoogle ScholarPubMed
Gur, R., Resnick, S., Gur, R., Alavi, A., Caroff, S., Kushner, M. & Revich, M. (1987). Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Archives of General Psychiatry 44, 126–129.CrossRefGoogle ScholarPubMed
Harris, M. (1986). Wisconsin Card Sorting Test: Computer Version Manual. Psychological Assessment Resources, Inc.: Odessa, Florida.Google Scholar
Heaton, R. (1981). Wisconsin Card Sorting Manual. Psychological Assessment Resources, Inc.: Odessa, Florida.Google Scholar
Jones, B. (1988). Hypofrontality in schizophrenia. Canadian Journal of Psychiatry 33, 243–245.CrossRefGoogle ScholarPubMed
Jones-Gotman, M. & Milner, B., (1977). Design fluency: the invention of nonsense drawings after focal cortical lesions. Neuropsychologia 15, 635–674.CrossRefGoogle ScholarPubMed
Kashima, H., Handa, T., Kato, M., Sakuma, K., Yokoyama, N., Murakami, M., Shigemori, K., Muramatsu, T., Saito, H., Ooe, Y., Mimura, M., Asai, M. & Hosaki, H. (1987). Neuropsychological investigation of chronic schizophrenia – aspects of its frontal functions. In Cerebral Dynamics, Laterality and Psychopathology (ed. Takahashi, R., Flor-Henry, P., Gruzelier, J. and Niwa, S.), pp. 337–345. Elsevier Science Publishers: Amsterdam.Google Scholar
Kear-Colwell, J. (1973). The structure of the Wechsler Memory Scale and its relationship to ‘brain damage’. British Journal of Social and Clinical Psychology 12, 384–392.CrossRefGoogle ScholarPubMed
Keilp, J., Sweeney, J., Jacobsen, P., Solomon, C., St. Louis, L., Deck, M., Frances, A. & Mann, J. (1988). Cognitive impairment in schizophrenia: specific relations to ventricular size and negative symptomatology. Biological Psychiatry 24, 47–55.CrossRefGoogle ScholarPubMed
Kolb, B. & Whishaw, I. (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal or parietal function in neurological patients. Journal of Nervous and Mental Disease 171, 435–443.CrossRefGoogle ScholarPubMed
Lezak, M. (1983). Neuropsychological Assessment. Oxford University Press: New York.Google Scholar
Milner, B. (1963). Effects of different brain lesions on card sorting. Archives of Neurology 9, 90–100.CrossRefGoogle Scholar
Milner, B. (1964). Some effects of Frontal lobectomy in man. In The Frontal Granular Cortex and Behavior (ed. Warren, J. M. and Ackert, K.), pp. 313–334. McGraw-Hill: New York.Google Scholar
Morrison, S. L., Williamson, P. C., Corning, W. C., Kutcher, S. P., Snow, W. G. & Merskey, H. (1991). Coherence on electroencephalography and aberrant functional organization of the brain in schizophrenic patients during activation tasks. British Journal of Psychiatry 159, (in the press).Google Scholar
Reynolds, G. (1989). Beyond the dopamine hypothesis: the neurochemical pathology of schizophrenia. British Journal of Psychiatry 155, 305–316.CrossRefGoogle ScholarPubMed
Sargent, M. (1988). Update on brain imaging. Hospital and Community Psychiatry 9, 933–934.Google Scholar
Seidman, L. (1983). Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychological Bulletin 94, 195–238.CrossRefGoogle ScholarPubMed
Spitzer, R. & Williams, J. (1985). Structured Clinical Interview for DSM-III-R. New York State Psychiatric Institute: New York.Google Scholar
SPSSX User's Guide. (1983). McGraw-Hill: New York.Google Scholar
Sternberg, R. (1984). Beyond IQ. Cambridge University Press: New York.Google Scholar
Taylor, M. & Abrams, R. (1984). Cognitive impairment in schizophrenia. American Journal of Psychiatry 141, 196–201.Google ScholarPubMed
Volkow, N., Wolf, A., Gelder, P., Brodie, J., Overall, J., Cancro, R. & Gomez-Mont, F. (1987). Phenomenological correlates of metabolism activity in 18 patients with chronic schizophrenia. American Journal of Psychiatry 144, 151–158.Google ScholarPubMed
Wechsler, D. (1972). Wechsler Memory Scale Form 1. Psychological Corporation: New York.Google Scholar
Weinberger, D. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660–669.CrossRefGoogle ScholarPubMed
Weinberger, D., Berman, K. & Zec, R. (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry 43, 114–124.CrossRefGoogle ScholarPubMed
Weinberger, D., Berman, K. & Illowsky, B. (1988). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monaminergic mechanism. Archives of General Psychiatry 45, 609–615.CrossRefGoogle Scholar
Williamson, P. (1987). Hypofrontality in schizophrenia: a review of the evidence. Canadian Journal of Psychiatry 32, 399–404.CrossRefGoogle ScholarPubMed
Williamson, P., Kutcher, S., Cooper, P., Snow, G., Szalai, J., Kaye, H., Morrison, S. L., Willinsky, R. & Mamelak, M. (1989). Psychological, topographic EEG, and CT scan correlates of frontal lobe function in schizophrenia. Psychiatry Research 29, 137–149.CrossRefGoogle ScholarPubMed
Wolkin, A., Jaeger, J., Brodie, J., Wolf, A., Fowler, J., Rotrosen, J., Gomez-Mont, G. & Cancro, R. (1985). Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry 142, 564–570.Google ScholarPubMed
Wolkin, A., Angrist, B.Wolf, A., Brodie, J., Wolkin, B., Jaeger, J., Cancro, R. & Rotrosen, J. (1988). Low frontal glucose utilization in chronic schizophrenia: a replication study. American Journal of Psychiatry 145, 251–253.Google ScholarPubMed
Wonderlic, C. F. (1983). Wonderlic Personnel Test. E. F. Wonderlic Personnel Test, Inc.: Northfield, III.Google Scholar