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Erythrocyte membrane cation carrier in mania

Published online by Cambridge University Press:  09 July 2009

G. J. Naylor ,
D. A. T. Dick ,
E. G. Dick ,
E. P. Worrall ,
M. Peet ,
P. Dick  and
L. J. Boardman
G. J. Naylor*
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
D. A. T. Dick
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
E. G. Dick
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
E. P. Worrall
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
M. Peet
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
P. Dick
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
L. J. Boardman
Affiliation:
Departments of Psychiatry and Anatomy, The University, Dundee
*
1Address for correspondence: Dr G. J. Naylor, Consultant Psychiatrist, Royal Dundee Liff Hospital, By Dundee DD2 5NF.
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Synopsis

Erythrocyte sodium and potassium concentrations, erythrocyte membrane ATPase (Na–K specific and non-specific) and the rate of potassium influx into erythrocytes (ouabainsensitive and insensitive) were estimated in a group of female patients suffering from mania and repeated on about two thirds of them when they had recovered. With recovery there was a statistically significant increase in the erythrocyte ouabain-sensitive potassium influx. The other parameters showed no significant overall change with recovery but the initial severity correlated significantly and negatively with the change in erythrocyte Na–K ATPase with recovery. The changes that occurred in the erythrocyte sodium concentration and Na–K ATPase activity were not random since they correlated significantly with changes in the active potassium influx.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 4 , February 1977 , pp. 659 - 663
Copyright
Copyright © Cambridge University Press 1977

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References

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