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Effects of carbamazepine on serum electrolytes in affectively ill patients

Published online by Cambridge University Press:  09 July 2009

Russell T. Joffe ,
Robert M. Post  and
Thomas W. Uhde
Russell T. Joffe
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Robert M. Post*
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Thomas W. Uhde
Affiliation:
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
*
1 Address for correspondence: Dr Robert M. Post, Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N212, 9000 Rockville Pike, Bethesda, MD 20205, USA.
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Synopsis

The effects on serum electrolytes of carbamazepine, an acute and prophylactic treatment for manic-depressive illness, were assessed in subjects with primary affective disorder. Carbamazepine caused statistically significant, but clinically insubstantial, reductions in serum sodium and calcium, but not in the other electrolytes measured. Decreases in serum sodium and calcium were not related to carbamazepine dose, blood levels, or the degree of clinical improvement. The theoretical implications of these findings are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 2 , May 1986 , pp. 331 - 335
Copyright
Copyright © Cambridge University Press 1986

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