Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-03T05:25:57.299Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of lithium administration on RNA metabolism in rat brain

Published online by Cambridge University Press:  09 July 2009

A. J. Dewar  and
H. W. Reading
A. J. Dewar
Affiliation:
M.R.C. Brain Metabolism Unit, Department of Pharmacology, University of Edinburgh
H. W. Reading
Affiliation:
M.R.C. Brain Metabolism Unit, Department of Pharmacology, University of Edinburgh
Get access Rights & Permissions [Opens in a new window]

Synopsis

An attempt has been made to explain the changes in uric acid levels observed in the phase of manic depressive illness by suggesting that they may be a reflection of changes in brain RNA metabolism. The effect of prolonged lithium administration on RNA synthesis in rat brain and liver has been studied. Differences in the rate of turnover of brain RNA between the lithium-treated and saline control animals have been observed.

Type
Research Article
Information
Psychological Medicine , Volume 1 , Issue 3 , May 1971 , pp. 254 - 259
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anumonye, A., Reading, H. W., Knight, F., and Ashcroft, G. W. (1968). Uric-acid metabolism in manic-depressive illness and during lithium therapy. Lancet, 1, 1290–1293.CrossRefGoogle ScholarPubMed
Cade, J. F. J. (1949). Lithium salts in the treatment of psychotic excitement. Medical Journal of Australia, 36, 349–352.CrossRefGoogle Scholar
Coppen, A., Malleson, A., and Shaw, D. M. (1965). Effects of lithium carbonate on electrolyte distribution in man. Lancet, 1, 682–683.CrossRefGoogle ScholarPubMed
Dow, R. C., Halliday, J., and Park, J. K. P. (1970). Personal communication.Google Scholar
Hurlbert, R. B., and Potter, V. R. (1952). A survey of the metabolism of orotic acid in the rat. Journal of Biological Chemistry, 195, 257–270.CrossRefGoogle Scholar
Lange, C. G. (1886). Om periodiske Depressionstilstande og deres Patogenese. Copenhagen.Google Scholar
Scherrer, K., and Darnell, J. A. (1962). Sedimentation characteristics of rapidly labelled RNA from Hela cells. Biochemical and Biophysical Research Communications, 7, 486–490.CrossRefGoogle ScholarPubMed
Schou, M. (1957). Biology and pharmacology of the lithium ion. Pharmacological Reviews, 9, 17–58.Google ScholarPubMed
Mayer-Gross, W. (1969). Clinical Psychiatry, p. 232. 3rd edn. Edited by Slater, E. and Roth, M.. Baillière, Tindall, and Cassell: London.Google Scholar
Suzuka, I., and Kaji, A. (1968). Reversible effect of lithium chloride on ribosomes. Journal of Biological Chemistry, 243, 3136–3141.CrossRefGoogle ScholarPubMed
Wright, T. L., Hoffman, L. H. and Davies, J.Lithium teratogenecity. Lancet, 2, 876.Google Scholar