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Down's Syndrome and Alzheimer's disease: a review

Published online by Cambridge University Press:  09 July 2009

C. Oliver  and
A. J. Holland
C. Oliver
Affiliation:
Institute of Psychiatry, London
A. J. Holland*
Affiliation:
Institute of Psychiatry, London
*
1Address for correspondence: Dr A. J. Holland, Genetic Unit, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

Neuropathological change found in nearly all individuals with Down's Syndrome over the age of 35 years closely resembles that of Alzheimer's disease. The extent to which dementia occurs as a result of this change is unclear, and the studies which have investigated presumed cognitive deficits are reviewed. The theories put forward to explain the association between these two disorders and their possible significance to the understanding of the aetiology of Alzheimer's disease are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 2 , May 1986 , pp. 307 - 322
Copyright
Copyright © Cambridge University Press 1986

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