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The dopamine D4 receptor in schizophrenia: an update1

Published online by Cambridge University Press:  09 July 2009

Robert W. Kerwin  and
David Collier
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Abstract

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Type
Editorial
Information
Psychological Medicine , Volume 26 , Issue 2 , March 1996 , pp. 221 - 227
Copyright
Copyright © Cambridge University Press 1996

References

REFERENCES

Barr, C. L., Kennedy, J. L., Licheter, J. B., Van Tol, H. H., Wetterberg, L., Livak, K. J. & Kidd, K. K. (1993). Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred. American Journal of Medical Genetics 48, 218–222.Google ScholarPubMed
Brucke, T.Roth, J., Podrecka, I., Strobi, R., Wenger, S. & Asenbaum, S. (1992). Striatal dopamine D2 blockade by typical and atypical neuroleptics. Lancet 339, 497.CrossRefGoogle ScholarPubMed
Campion, D., d'Amato, T., Bastard, C., Laurent, C., Guedj, F., Jay, M., Dolifus, S., Thibaut, F., Petit, M., Gorwood, P., Babron, M. C., Waksman, G., Martinez, M. & Mallet, J. (1994). Genetic study of dopamine D1, D2 and D4 receptors. Psychiatry Research 51, 215–230.CrossRefGoogle ScholarPubMed
Catalano, M., Nobile, M., Novelli, E., Nothen, M. M. & Smeraldi, E. (1993). Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biological Psychiatry 34, 459–464.Google ScholarPubMed
Chabert, C., Cavegn, C., Bernard, A. & Mills, A. (1994). Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors. Journal of Neurochemistry 63 62–65.CrossRefGoogle ScholarPubMed
Cohen, A. I., Todd, R. D., Harmon, S. & O'Malley, K. L. (1992). Photoreceptors of mouse retina possess D4 receptors coupled to adenylate cylase. Proceedings of the National Academy of Sciences 89, 12093–12097.Google Scholar
Coon, H., Byerley, W., Holik, J., Hoff, M., Myles-Worsley, M., Lannfelt, L., Sokoloff, P., Schwartz, J. C., Waldo, M., Freedman, R. & Plaetke, R. (1993). Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees. American Journal of Human Genetics 52, 327–334.Google ScholarPubMed
Cross, A. J., Crow, T. J. & Owen, F. (1981). 3H-flupanthixol binding in post-mortem brains of schizophrenics: evidence for a selective increase in dopamine D2 receptors. Psychopharmacology 74, 122–124.CrossRefGoogle ScholarPubMed
Crow, T. J. (1995). A darwinian approach to the origins of psychosis. British Journal of Psychiatry 167, 12–25.CrossRefGoogle Scholar
Culiat, C. T., Stubbs, L., Nicholls, R. D., Montgomery, C. S., Russell, L. B., Johnson, D. K. & Rinchik, E. M. (1993). Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the β3 subunit of the type A γ-aminobutyric acid receptor. Proceedings of the National Academy of Science of the USA 90, 5105–5109.CrossRefGoogle Scholar
Culiat, C. T., Stubbs, L. J., Montgomery, C. S., Russell, L. B., & Rinchik, E. M. (1994). Phenotypic consequences of deletion of the γ3, α5 or β3 subunit of the type A γ-aminobutyric acid receptor in mice. Proceedings of the National Academy of Science of the USA 91, 2815–2818.CrossRefGoogle Scholar
De-bruyn, A., Mendelbaum, K., Sandkuijl, L. A., Delvenne, V., Hirsch, D., Staner, L., Mendlewicz, J. & Van-Broeckhoven, C. (1994). Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11. American Journal of Psychiatry 151, 102–106.Google ScholarPubMed
Farde, L., Weisel, F. A., Stone-Elander, S., Halldin, C., Nordstrom, A. L., Hall, H. & Sedvall, G. (1990). D2 dopamine receptors in neuroleptic naive schizophrenic patients. Archives of General Psychiatry 47, 213–219.CrossRefGoogle ScholarPubMed
Farde, L., Nordstrom, A. L., Weisel, F.-A., Paulin, F., Halldin, C. & Sedvall, G. (1992). Positron emission tomographic analysis of central D1 and D2 receptor occupancy in patients treated with classical neuroleptics and clozapine. Archives of General Psychiatry 49, 538–544.CrossRefGoogle ScholarPubMed
Flamez, A., De Backer, J. P., Wilczak, N., Vaquelin, G. & DeKeyser, J. (1994). 3H-clozapine is not a suitable radioligand for the labelling of D4 dopamine receptors in post-mortem human brain. Neuroscience Letters 175, 17–20.CrossRefGoogle Scholar
Gerlenter, J., Kennedy, J. L., Van Tol, H. H. M., Civelli, O. & Kidd, K. K. (1992). The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13, 208–210.CrossRefGoogle Scholar
Iversen, L. L. (1993). The D4 and schizophrenia. Nature, 365, 393.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Carney, M. W. P. & Price, J. S. (1978). Mechanism of the antipsychotic effect in acute schizophrenia. Lancet i, 848–851.CrossRefGoogle Scholar
Kennedy, J. L.Sidenberg, D. G., Van Tol, H. H. M. & Kidd, K. K. (1993). A Hincll RFLP in the human D4 dopamine receptor locus (DRD4). Nucleic Acids Research 19, 5801.CrossRefGoogle Scholar
Kennedy, J. L., Petronis, A., Gao, J., Macciardi, F. M., Van Tol, H. H. M., Cola, P. & Meltzer, H. Y. (1994). Genetic Studies of DRD4 and clinical response to neuroleptic medications. American Journal of Human Genetics 55, 3.Google Scholar
Kerwin, R. W. (1992). A history of frontal and temporal lobe aspects of the neuropharmacology of schizophrenia. Journal of Psychopharmacology 6, 230–240.Google ScholarPubMed
Lahti, R. A., Evans, D. L., Stratman, N. C. & Figur, L. M. (1993). Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. European Journal of Pharmacology 236, 483–486.CrossRefGoogle ScholarPubMed
Lichter, J. B., Ball, C. L., Kennedy, J. L. et al. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics 2, 767–773.CrossRefGoogle ScholarPubMed
McGuffin, P. (1988). Genetics of schizophrenia. In Schizophrenia the Major Issues (ed. Bebbington, P. and McGuffin, P.), pp. 167–176. Heineman Medical: London.Google Scholar
Mackay, A. V., Doble, A., Bird, E. D., Bird, E., Spokes, E. G., Quirk, M. & Iversen, L. L. (1978). 3H-spiperone binding in normal and schizophrenic post mortem human brain. Life Sciences 23, 527–532.CrossRefGoogle ScholarPubMed
Macciardi, F., Petronic, A., Van Tol, H. H. M., Marino, C., Cavallini, M. C., Smeraldi, E. & Kennedy, J. L. (1994). Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred. Archives of General Psychiatry 51, 288–293.CrossRefGoogle Scholar
Martinot, J. L., Pailliere-Martinot, M. L., Loc'h, C., Hardy, P., Porrier, M. F., Mazoyer, B., Beaufils, B., Maziere, B., Allilaile, J. P. & Syrota, A. (1991). The estimated density of D2 striatal receptors in schizophrenia. A study with positron emission tomography and 76Bromolisuride. British Journal of Psychiatry 158, 346–350.Google Scholar
Murray, A. M., Hyde, T. M., Knable, M. B., Herman, M., Bigelow, B., Carter, J. M., Weinberger, D. R. & Kleinman, J. E. (1995). Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia. Journal of Neuroscience 15, 2186–2191.Google ScholarPubMed
Nothen, M., Cichon, S., Hemmer, S., Hebebrand, J., Remschmidt, H., Lehmkuhl, G., Poustka, F., Schmidt, M., Catalaho, M., Fimmers, R., Korna, J., Reitxhell, M. & Propping, P. (1994). Human dopamine D4 receptor gene: frequent occurrance of a null allele and observations of the homozygosily. Human Molecular Genetics 3, 2207–2212.CrossRefGoogle Scholar
Petronis, A., Van Tol, H. H. M., Yang, L., Li, T., Macciardi, F. M. & Kennedy, J. L. (1993). Population and linkage disequilibrium analysis of new polymorphisms at the DRD4 locus. American Journal of Human Genetics 53, Abstract No. 1707.Google Scholar
Petronis, A., Van Tol, H. H. M. & Kennedy, J. (1994 a). A Smal PCR-RFLP in the 5′ non-coding region of the human D4 dopamine receptor gene DRD4, Human Heredity 44, 58–60.CrossRefGoogle Scholar
Petronis, A., O'Hara, K., Barr, C. L., Kennedy, J. L. & Van Tol, H. H. M. (1994 b). (G)n-mononucleotide polymorphism in human D4 dopamine receptor (DRD4) gene. Human Genetics 93, 719.CrossRefGoogle ScholarPubMed
Pilowsky, L. S., Costa, D. C., Ell, P. J., Murray, R. M., Verhoeff, N. P. L. G. & Kerwin, R. W. (1992). Clozapine, single photon emission tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 340, 199–202.CrossRefGoogle ScholarPubMed
Pilowsky, L. S., Costa, D. C., Ell, P. J., Murray, R. M., Verhoeff, N. P. L. & Kerwin, R. W. (1993). Antipsychotic medication D2 dopamine receptor blockade and clinical response: a 123I-IBZM SPET (single photon emission tomography) study. Psychological Medicine 23, 791–797.CrossRefGoogle ScholarPubMed
Randrup, A. & Munkvad, I. (1967). Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia 11, 300–310.CrossRefGoogle ScholarPubMed
Rao, P., Pickar, D., Gejman, P., Ram, A., Gershon, S. & Gelernter, J. (1994). Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Archives of General Psychiatry 51, 912–917.CrossRefGoogle Scholar
Reynolds, G. P. & Mason, S. L. (1994). Are striatal dopamine D4 receptors increased in schizophrenia. Journal of Neurochemistry 63, 1576–1578.CrossRefGoogle ScholarPubMed
Seeman, P., Ulpian, C., Chouinard, G., Van Tol, H. H. M., Dwosh, H., Lieberman, J. A., Siminovitch, K., Liu, I. S. C., Waye, J., Voruganti, P., Hudson, C., Serjeant, G. R., Masibay, A. S. & Seeman, M. V. (1994). Dopamine D4 receptor variant, D4glycine194, in Africans, but not in Caucasians: no association with schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics) 54, 384–390.CrossRefGoogle Scholar
Seeman, P. (1992). Elevated D2 in schizophrenia. Neuropsychopharmacology 1, 55–57.Google Scholar
Seeman, P. & Van Tol, H. H. M. (1993). Dopamine D4 receptors bind inactive (+) aporphines, suggesting neuroleptic role. Sulpride not stereoselective. European Journal of Pharmacology 233, 173–174.CrossRefGoogle Scholar
Seeman, P., Lee, T., Chou-Wong, M. et al. (1976). Antipsychotic drug does and neuroleptic/dopamine receptors. Nature 261, 717–718.CrossRefGoogle ScholarPubMed
Seeman, P., Guan, H. C. & Van Tol, H. H. M. (1993 a). Dopamine D4 receptors elevated in schizophrenia. Nature 365, 441–444.CrossRefGoogle ScholarPubMed
Seeman, P., Guan, H. C., Van Tol, H. H. M. & Niznick, H. B. (1993 a). Low density of dopamine D4 receptors in Parkinson's, schizophrenia and control brain striata. Synapse, 14, 247–253.CrossRefGoogle ScholarPubMed
Shaikh, S., Collier, D. H., Kerwin, R. W., Pilowsky, L., Gill, M., Xu, W. & Thornton, A. (1993). Dopamine D4 receptor subtypes and response to clozapine. Lancet 341, 116.CrossRefGoogle ScholarPubMed
Shaikh, S., Gill, M., Owen, M., Asherson, P., McGuffin, P., Nanko, S., Murray, R. M. & Collier, D. (1994). Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics) 54, 8–11.CrossRefGoogle ScholarPubMed
Shaikh, S., Collier, D. H., Sham, P., Pilowsky, L., Sharma, T., Lin, L. K., Crocq, M. A., Gill, M. & Kerwin, R. W. (1996). An analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene DRD4 in schizophrenic patients. American Journal of Medical Genetics (Neuropsychiatric Genetics). (In the press.)Google Scholar
Sibley, D. R. & Monsma, F. J. (1992). Molecular Biology of dopamine receptors. Trends in Pharmacological Sciences, 13, 61–69.CrossRefGoogle ScholarPubMed
Sidenberg, K. G., King, N. & Kennedy, J. L. (1994). Analysis of new D4 dopamine receptor (DRD4) coding region variants and TH microsatellite in old order Amish family (OOA 110). Psychiatric Genetics 4, 95–99.CrossRefGoogle Scholar
Sobell, J. L., Heston, L. L. & Sommer, S. S. (1992). Delineation of genetic predisposition to multifactorial disease. A general approach on the threshold of feasibility. Genomics 12, 1–16.CrossRefGoogle ScholarPubMed
Van Tol, H. H. M., Bunzow, J. R., Guan, H. C., Suhuhara, R. K., Seeman, P., Niznick, H. B. & Civelli, O. (1991). Cloning of the gene for human D4 receptor with high affinity for the antipsychotic clozapine. Nature 350, 610–619.CrossRefGoogle ScholarPubMed
Van Tol, H. H. M., Wu, C. M., Guan, H. C., O'Hara, K., Bunzow, R., Civelli, O., Kennedy, J., Seeman, P., Niznick, H. B. & Jovanvic, V. (1992). Multiple dopamine D4 receptor variants in the human population. Nature 358, 149–192.Google ScholarPubMed
Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussoll, J. P., Ravaerb, H. T., Wilson, A. A., Thomas Toung, J. K., Maalat, J., Williams, J. A., O'Tuama, L. A., Snyder, S. H., Kuhar, M. J. & Gjedde, A. (1986). Positron emission tomography reveals elevated D2 receptors in drug naive schizophrenics. Science, 234, 1558–1563.CrossRefGoogle ScholarPubMed