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Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

Published online by Cambridge University Press:  27 January 2010

M. Shaikh ,
M.-H. Hall ,
K. Schulze ,
A. Dutt ,
M. Walshe ,
I. Williams ,
M. Constante ,
M. Picchioni ,
T. Toulopoulou  and
D. Collier
...Show all authors
M. Shaikh*
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
M.-H. Hall
Affiliation:
Psychology Research Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA
K. Schulze
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
A. Dutt
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
M. Walshe
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
I. Williams
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
M. Constante
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
M. Picchioni
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK St Andrew's Academic Centre, King's College London, Institute of Psychiatry, Northampton, UK
T. Toulopoulou
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
D. Collier
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
F. Rijsdijk
Affiliation:
MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
J. Powell
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
M. Arranz
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
R. M. Murray
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
E. Bramon
Affiliation:
NIHR Biomedical Research Centre, Institute of Psychiatry, King's College London/South London and Maudsley NHS Foundation Trust, London, UK
*
*Address for correspondence: Ms. M. Shaikh, Division of Psychological Medicine and Psychiatry, P063, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. (Email: [email protected])
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Abstract

Background

Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.

Method

The possible role of NRG1, COMT Val158Met and BDNF Val66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.

Results

Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val158Met or BDNF Val66Met genotypes and the P50 endophenotype.

Conclusions

The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val158Met or BDNF Val66Met genotypes, if present, must be very subtle.

Keywords

BDNFCOMTNRG1psychosisP50
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 2 , February 2011 , pp. 263 - 276
Copyright
Copyright © Cambridge University Press 2010

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