Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-24T14:10:06.324Z Has data issue: false hasContentIssue false
  • English
  • Français

The dice are rolling for schizophrenia genetics

A commentary on ‘The emperors of the schizophrenia polygene have no clothes’ by Crow (2008)

Published online by Cambridge University Press:  04 June 2008

P. F. Sullivan
P. F. Sullivan*
Affiliation:
Departments of Genetics, Psychiatry, & Epidemiology, University of North Carolina at Chapel Hill, NC, USA Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden
*
*Address for correspondence: P. F. Sullivan, M.D., FRANZCP, Department of Genetics, CB#7264, 4109D Neurosciences Research Building, University of North Carolina, Chapel Hill, NC, 27599-7264, USA. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

Evidencegenome-wide associationgenome-wide linkagemeta-analysisschizophrenia
Type
Commentary
Information
Psychological Medicine , Volume 38 , Issue 12 , December 2008 , pp. 1693 - 1696
Copyright
Copyright © 2008 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, N, Bagade, S, McQueen, M, Ioannidis, J, Kavvoura, F, Khoury, M, Tanzi, R, Bertram, L (in press). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the szgene database. Nature Genetics.Google Scholar
Chanock, SJ, Manolio, T, Boehnke, M, Boerwinkle, E, Hunter, DJ, Thomas, G, Hirschhorn, JN, Abecasis, G, Altshuler, D, Bailey-Wilson, JE, Brooks, LD, Cardon, LR, Daly, M, Donnelly, P, Fraumeni, JF Jr., Freimer, NB, Gerhard, DS, Gunter, C, Guttmacher, AE, Guyer, MS, Harris, EL, Hoh, J, Hoover, R, Kong, CA, Merikangas, KR, Morton, CC, Palmer, LJ, Phimister, EG, Rice, JP, Roberts, J, Rotimi, C, Tucker, MA, Vogan, KJ, Wacholder, S, Wijsman, EM, Winn, DM, Collins, FS (2007). Replicating genotype-phenotype associations. Nature 447, 655–660.Google ScholarPubMed
Crow, TJ (2008). The emperors of the schizophrenia polygene have no clothes. Psychological Medicine. Published online: 21 April 2008. doi:10.1017/S0033291708003395.CrossRefGoogle ScholarPubMed
Frayling, TM (2007). Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nature Reviews Genetics 8, 657–662.CrossRefGoogle ScholarPubMed
Frayling, TM, Timpson, NJ, Weedon, MN, Zeggini, E, Freathy, RM, Lindgren, CM, Perry, JR, Elliott, KS, Lango, H, Rayner, NW, Shields, B, Harries, LW, Barrett, JC, Ellard, S, Groves, CJ, Knight, B, Patch, AM, Ness, AR, Ebrahim, S, Lawlor, DA, Ring, SM, Ben-Shlomo, Y, Jarvelin, MR, Sovio, U, Bennett, AJ, Melzer, D, Ferrucci, L, Loos, RJ, Barroso, I, Wareham, NJ, Karpe, F, Owen, KR, Cardon, LR, Walker, M, Hitman, GA, Palmer, CN, Doney, AS, Morris, AD, Davey-Smith, G, Hattersley, AT, McCarthy, MI (2007). A common variant in the fto gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894.CrossRefGoogle ScholarPubMed
Konneker, T, Barnes, T, Furberg, H, Losh, M, Bulik, CM, Sullivan, PF (in press). A searchable database of genetic evidence for psychiatric disorders. American Journal of Medical Genetics (Neuropsychiatric Genetics).Google Scholar
Lencz, T, Morgan, TV, Athanasiou, M, Dain, B, Reed, CR, Kane, JM, Kucherlapati, R, Malhotra, AK (2007). Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Molecular Psychiatry 12, 572–580.CrossRefGoogle ScholarPubMed
Psychiatric GWAS Consortium (PGC) (in press). A framework for interpreting genomewide association studies of psychiatric disorders. American Journal of Psychiatry.Google Scholar
Sanders, A, Duan, J, Levinson, DF, Shi, J, He, D, Hou, C, Burrell, GJ, Rice, JP, Nertney, DA, Olincy, A, Rozic, P, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Crowe, RR, Cloninger, CR, Martinez, M, Gejman, P (2008). No significant association of fourteen candidate genes to schizophrenia in a large european-ancestry sample: implications for the field. American Journal of Psychiatry 165, 497–506.CrossRefGoogle Scholar
Saxena, R, Voight, BF, Lyssenko, V, Burtt, NP, de Bakker, PI, Chen, H, Roix, JJ, Kathiresan, S, Hirschhorn, JN, Daly, MJ, Hughes, TE, Groop, L, Altshuler, D, Almgren, P, Florez, JC, Meyer, J, Ardlie, K, Bengtsson, K, Isomaa, B, Lettre, G, Lindblad, U, Lyon, HN, Melander, O, Newton-Cheh, C, Nilsson, P, Orho-Melander, M, Rastam, L, Speliotes, EK, Taskinen, MR, Tuomi, T, Guiducci, C, Berglund, A, Carlson, J, Gianniny, L, Hackett, R, Hall, L, Holmkvist, J, Laurila, E, Sjogren, M, Sterner, M, Surti, A, Svensson, M, Tewhey, R, Blumenstiel, B, Parkin, M, Defelice, M, Barry, R, Brodeur, W, Camarata, J, Chia, N, Fava, M, Gibbons, J, Handsaker, B, Healy, C, Nguyen, K, Gates, C, Sougnez, C, Gage, D, Nizzari, M, Gabriel, SB, Chirn, GW, Ma, Q, Parikh, H, Richardson, D, Ricke, D, Purcell, S (2007). Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331–1336.CrossRefGoogle ScholarPubMed
Scott, LJ, Mohlke, KL, Bonnycastle, LL, Willer, CJ, Li, Y, Duren, WL, Erdos, MR, Stringham, HM, Chines, PS, Jackson, AU, Prokunina-Olsson, L, Ding, CJ, Swift, AJ, Narisu, N, Hu, T, Pruim, R, Xiao, R, Li, XY, Conneely, KN, Riebow, NL, Sprau, AG, Tong, M, White, PP, Hetrick, KN, Barnhart, MW, Bark, CW, Goldstein, JL, Watkins, L, Xiang, F, Saramies, J, Buchanan, TA, Watanabe, RM, Valle, TT, Kinnunen, L, Abecasis, GR, Pugh, EW, Doheny, KF, Bergman, RN, Tuomilehto, J, Collins, FS, Boehnke, M (2007). A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–1345.CrossRefGoogle ScholarPubMed
Shifman, S, Johannesson, M, Bronstein, M, Chen, SX, Collier, DA, Craddock, NJ, Kendler, KS, Li, T, O'Donovan, M, O'Neill, FA, Owen, MJ, Walsh, D, Weinberger, DR, Sun, C, Flint, J, Darvasi, A (2008). Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genetics 4, e28.CrossRefGoogle ScholarPubMed
Stefansson, H, Sigurdsson, E, Steinthorsdottir, V, Bjornsdottir, S, Sigmundsson, T, Ghosh, S, Brynjolfsson, J, Gunnarsdottir, S, Ivarsson, O, Chou, TT, Hjaltason, O, Birgisdottir, B, Jonsson, H, Gudnadottir, VG, Gudmundsdottir, E, Bjornsson, A, Ingvarsson, B, Ingason, A, Sigfusson, S, Hardardottir, H, Harvey, RP, Lai, D, Zhou, M, Brunner, D, Mutel, V, Gonzalo, A, Lemke, G, Sainz, J, Johannesson, G, Andresson, T, Gudbjartsson, D, Manolescu, A, Frigge, ML, Gurney, ME, Kong, A, Gulcher, JR, Petursson, H, Stefansson, K (2002). Neuregulin 1 and susceptibility to schizophrenia. American Journal of Human Genetics 71, 877–892.CrossRefGoogle ScholarPubMed
Straub, RE, Jiang, Y, MacLean, CJ, Ma, Y, Webb, BT, Myakishev, MV, Harris-Kerr, C, Wormley, B, Sadek, H, Kadambi, B, Cesare, AJ, Gibberman, A, Wang, X, O'Neill, FA, Walsh, D, Kendler, KS (2002). Genetic variation in the 6p22.3 gene dtnbp1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. American Journal of Human Genetics 71, 337–348. [Erratum in American Journal of Human Genetics (2002), 72, 1007.]CrossRefGoogle ScholarPubMed
Sullivan, PF (2007). Spurious genetic associations. Biological Psychiatry 61, 1121–1126.CrossRefGoogle ScholarPubMed
Sullivan, PF, Lin, D, Tzeng, JY, van den Oord, EJCG, Perkins, D, Stroup, TS, Wagner, M, Lee, S, Wright, FA, Zou, F, Liu, W, Downing, AM, Lieberman, JA, Close, SL (2008). Genomewide association for schizophrenia in the CATIE study: results of stage 1. Molecular Psychiatry 13, 570–584.CrossRefGoogle ScholarPubMed
Walsh, T, McClellan, JM, McCarthy, SE, Addington, AM, Pierce, SB, Cooper, GM, Nord, AS, Kusenda, M, Malhotra, D, Bhandari, A, Stray, SM, Rippey, CF, Roccanova, P, Makarov, V, Lakshmi, B, Findling, RL, Sikich, L, Stromberg, T, Merriman, B, Gogtay, N, Butler, P, Eckstrand, K, Noory, L, Gochman, P, Long, R, Chen, Z, Davis, S, Baker, C, Eichler, EE, Meltzer, PS, Nelson, SF, Singleton, AB, Lee, MK, Rapoport, JL, King, MC, Sebat, J (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320, 539–543.CrossRefGoogle ScholarPubMed
Weiss, LA, Shen, Y, Korn, JM, Arking, DE, Miller, DT, Fossdal, R, Saemundsen, E, Stefansson, H, Ferreira, MA, Green, T, Platt, OS, Ruderfer, DM, Walsh, CA, Altshuler, D, Chakravarti, A, Tanzi, RE, Stefansson, K, Santangelo, SL, Gusella, JF, Sklar, P, Wu, BL, Daly, MJ (2008). Association between microdeletion and microduplication at 16p11.2 and autism. New England Journal of Medicine 358, 667–675.CrossRefGoogle ScholarPubMed