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Daily variations of the urine content of 3-methoxy-4-hydroxyphenylglycol in two manic-depressive patients

Published online by Cambridge University Press:  09 July 2009

P. A. Bond ,
F. A. Jenner  and
Gwyneth A. Sampson
P. A. Bond
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
F. A. Jenner
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
Gwyneth A. Sampson
Affiliation:
Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield
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Synopsis

Daily measurements of MHPG in urine have been carried out in two patients with manic-depressive psychosis. In both cases, levels in mania were elevated and in depression lowered with interval levels which were intermediate and within the normal range. The results lend some support to the suggestion that there might be an increase in brain noradrenaline metabolism in mania and a decrease in depression.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 2 , Issue 1 , February 1972 , pp. 81 - 85
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

Bond, P. A. (1971). The determination of 4-hydroxy-3-methoxyphenylethylene glycol in urine and C.S.F. using gas chromatography. Biochemical Mediane. (In press.)Google Scholar
Chase, T. N., Breese, G. R., Gordon, E. K., and Kopin, I. J. (1971). Catecholamine metabolism in the dog: comparison of intravenously and intraventricularly administered [14C] dopamine and [3H] norepinephrine. Journal of Neurochemistry, 18, 135–140.CrossRefGoogle Scholar
Gitlow, S. E., Mendlowitz, M., Bertani, L. M., Wilk, S., and Wilk, E. K.(1971). Human norepinephrine metabolism. Its evaluation by administration of tritiated norepinephrine. Journal of Clinical Investigation, 50, 859–865.CrossRefGoogle ScholarPubMed
Greenspan, K., Schildkraut, J. J., Gordon, E. K., Baer, L., Aronoff, M. S., and Durell, J. (1970). Catecholamine metabolism in affective disorders. III. MHPG and other Catecholamine metabolites in patients treated with lithium carbonate. Journal of Psychiatric Research, 7, 171–183.CrossRefGoogle Scholar
Jenner, F. A., Gjessing, L. R., Cox, J. R., Davies-Jones, A., Hullin, R. P., and Hanna, S. M. (1967). A manic depressive psychotic with a persistent forty-eight hour cycle. British Journal of Psychiatry, 113, 895–910.CrossRefGoogle ScholarPubMed
Maas, J. W., Fawcett, J., and Dekirmenjian, H. (1968). 3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive States. Archives of General Psychiatry, 19, 129–134.CrossRefGoogle ScholarPubMed
Maas, J. W., and Landis, D. H. (1968). In vivo Studies of the metabolism of norepinephrine in the central nervous System. Journal of Pharmacology and Experimental Therapeutics, 163, 147–162.Google Scholar
Schanberg, S. M., Breese, G. R., Schildkraut, J. J., Gordon, E. K., and Kopin, I. J. (1968). 3-Methoxy-4-hydroxy phenylglycol sulfate in brain and cerebrospinal fluid. Biochemical Pharmacology, 17, 2006–2008.CrossRefGoogle Scholar
Schanberg, S. M., Shildkraut, J. J., Breese, G. R., and Kopin, I. J. (1968). Metabolism of normetanephrine-H3 in rat brain—identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite. Biochemical Pharmacology, 17, 247–254.CrossRefGoogle ScholarPubMed
Sharman, D. F. (1969). Glycol metabolites of noradrenaline in brain tissue. British Journal of Pharmacology, 36, 523–534.CrossRefGoogle ScholarPubMed
Schildkraut, J. J. (1965). The Catecholamine hypothesis of affective disorders: a review of supporting evidence. American Journal of Psychiatry, 122, 509–522.CrossRefGoogle ScholarPubMed
Siegel, S. (1956). Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill: New York.Google Scholar
Shimizu, H., and La Brosse, E. H. (1969). Metabolism of catecholamines—identification and quantification of 3-methoxy-4-hydroxyphenylglycol glucuronide in human urine. Biochemical Pharmacology, 18, 1643–1654.CrossRefGoogle Scholar
Wilk, S., Davis, K. L., and Thacker, S. B. (1971). Determination of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in cerebrospinal fluid. Analytical Biochemistry, 39, 498–504.CrossRefGoogle ScholarPubMed
Wilk, S., Gitlow, S. E., Clarke, D. D., and Paley, D. H. (1967). Determination of urinary 3-methoxy-4-hydroxy-phenylethylene glycol by gas-liquid chromatography and electron capture detection. Clinica Chimica Acta, 16, 403–408.CrossRefGoogle Scholar