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Cyclic AMP in cerebrospinal fluid of manic and depressive patients

Published online by Cambridge University Press:  09 July 2009

Robert M. Post ,
Hinrich Cramer  and
Frederick K. Goodwin
Robert M. Post*
Affiliation:
From the Sections on Psychiatry and Psychobiology, National Institute of Mental Health, Bethesda, Maryland USA, and the Department of Neurology and Neurophysiology, University of Freiburg, Germany
Hinrich Cramer
Affiliation:
From the Sections on Psychiatry and Psychobiology, National Institute of Mental Health, Bethesda, Maryland USA, and the Department of Neurology and Neurophysiology, University of Freiburg, Germany
Frederick K. Goodwin
Affiliation:
From the Sections on Psychiatry and Psychobiology, National Institute of Mental Health, Bethesda, Maryland USA, and the Department of Neurology and Neurophysiology, University of Freiburg, Germany
*
1Address for correspondence: Dr Robert M. Post, section on Psychobiology, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014, USA.
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Synopsis

Cyclic 3′5′-adenosine monophosphate (c-AMP) was measured in cerebrospinal fluid (CSF) of manic and depressive patients with and without probenecid administration both before and during treatment with various psychotropic drugs. Oral probenecid (100 mg/kg) produced substantial c-AMP accumulations in CSF suggesting a probenecid-sensitive transport mechanism for c-AMP. Baseline and probenecid-induced accumulations of c-AMP were not significantly different in manic and depressed patients, while baseline levels in depressed patients were higher than those in neurological controls. Imipramine, amitriptyline, lithium, tryptophan, and electroconvulsant therapies did not significantly alter levels or accumulations of c-AMP in CSF of depressed patients.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 4 , November 1977 , pp. 599 - 605
Copyright
Copyright © Cambridge University Press 1977

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