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A controlled study of 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia

Published online by Cambridge University Press:  09 July 2009

S. W. Lewis ,
R. A. Ford ,
G. M. Syed ,
A. M. Reveley  and
B. K. Toone
S. W. Lewis*
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School; Springfield Hospital; Departments of Nuclear Medicine and Psychiatry, King's College Hospital; Department of Psychiatry, Maudsley Hospital, London
R. A. Ford
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School; Springfield Hospital; Departments of Nuclear Medicine and Psychiatry, King's College Hospital; Department of Psychiatry, Maudsley Hospital, London
G. M. Syed
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School; Springfield Hospital; Departments of Nuclear Medicine and Psychiatry, King's College Hospital; Department of Psychiatry, Maudsley Hospital, London
A. M. Reveley
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School; Springfield Hospital; Departments of Nuclear Medicine and Psychiatry, King's College Hospital; Department of Psychiatry, Maudsley Hospital, London
B. K. Toone
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School; Springfield Hospital; Departments of Nuclear Medicine and Psychiatry, King's College Hospital; Department of Psychiatry, Maudsley Hospital, London
*
1 Address for correspondence: Dr S. W. Lewis, Department of Psychiatry, Charing Cross and Westminster Medical School, London W6 8RP.
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Synopsis

Regional cerebral blood flow (rCBF) during a word fluency task was compared in twenty-five male, right-handed, medicated schizophrenic patients and twenty-five age-matched male, right-handed healthy volunteers, using 99mtechnetium-HMPAO multidetector single-photon emission tomography. Increased rCBF in caudate and thalamus was found in patients, probably secondary to neuroleptic medication. Patients showed decreased rCBF in left frontal cortical regions and increased rCBF in left posterior cortical regions, compared to controls. Patterns of left-sided frontal rCBF dominance in controls were reversed in patients, as were normal patterns of right-sided parietal rCBF dominance. Negative symptom score correlated inversely with mesial frontal rCBF, particularly on the left.

Type
Original Articles
Information
Psychological Medicine , Volume 22 , Issue 1 , February 1992 , pp. 27 - 35
Copyright
Copyright © Cambridge University Press 1992

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