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A controlled family history study of bulimia

Published online by Cambridge University Press:  09 July 2009

James I. Hudson ,
Harrison G. Pope Jr ,
Jeffrey M. Jonas ,
Deborah Yurgelun-Todd  and
Frances R. Frankenburg
James I. Hudson*
Affiliation:
Epidemiology Laboratory, Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School; Eating Disorders Program, Fair Oaks Hospital, Summit, NJ, USA
Harrison G. Pope Jr
Affiliation:
Epidemiology Laboratory, Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School; Eating Disorders Program, Fair Oaks Hospital, Summit, NJ, USA
Jeffrey M. Jonas
Affiliation:
Epidemiology Laboratory, Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School; Eating Disorders Program, Fair Oaks Hospital, Summit, NJ, USA
Deborah Yurgelun-Todd
Affiliation:
Epidemiology Laboratory, Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School; Eating Disorders Program, Fair Oaks Hospital, Summit, NJ, USA
Frances R. Frankenburg
Affiliation:
Epidemiology Laboratory, Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School; Eating Disorders Program, Fair Oaks Hospital, Summit, NJ, USA
*
1Address correspondence and reprint requests to: Dr J. I. Hudson, McLean Hospital, 115 Mill St., Belmont, MA 02178, USA.
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Synopsis

Using the family history method, we assessed the morbid risk for psychiatric disorders the first-degree relatives of 69 probands with bulimia, 24 probands with major depression, and nonpsychiatric control probands. The morbid risk for major affective disorder among the first-degree relatives of the bulimic probands was 32%, significantly greater than that found in the nonpsychiatric control probands. The rate of familial major affective disorder was significantly greater in bulimic probands who had a history of major affective disorder themselves than in bulimic probands without such a history - but the latter group, in turn, displayed significantly higher rates than the nonpsychiatric control probands. Eating disorders were slightly, but not significantly, more prevalent in the families of bulimic probands than nonpsychiatric control probands. We present two alternative hypotheses which might explain these findings.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 4 , November 1987 , pp. 883 - 890
Copyright
Copyright © Cambridge University Press 1987

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References

American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders (3rd edn). American Psychiatric Association: Washington D.C.Google Scholar
Andreasen, N. C., Endicott, J., Spitzer, R. L. & Winokur, G. (1977). The family history method using diagnostic criteria. Archives of General Psychiatry 34, 1229–1235.Google Scholar
Biederman, J., Rivinus, T., Kemper, K., Hamilton, D., MacFadyen, J. & Harmatz, J. (1985). Depressive disorders in relatives of anorexia nervosa patients with and without a current episode of nonbipolar major depression. American Journal of Psychiatry 142, 1495–1496.Google Scholar
Blouin, J., Blouin, A., Perez, E., Seidel, B. & Bushnik, T. (1986). Family history factors in bulimia.Presented at the Second International Conference on Eating Disorders,New York,April, 1986.Google Scholar
Blumer, D. & Heilbronn, M. (1982). Chronic pain as a variant of depressive disease: the pain-prone disorder Journal of Nervous and Mental Disease 170, 381–406.Google Scholar
Cantwell, D. P., Steuzenberger, S., Burroughs, J, Salkin, B. & Green, J. K. (1977). Anorexia nervosa: an affective disorder? Archives of General Psychiatry 34, 1087–1093.CrossRefGoogle ScholarPubMed
Cassileth, B. R., Lusk, E. J., Strouse, T. B., Miller, D. S., Brown, L. L., Cross, P. A. & Tenaglia, A. N. (1984). Psychosocial status in chronic illness: a comparative analysis of six diagnostic groups. New England Journal of Medicine 311, 506–511.CrossRefGoogle ScholarPubMed
Crisp, A. H., Hsu, L. K. G., Harding, B. & Hartshorn, J. (1980). Clinical features of anorexia nervosa. British Journal of Psychiatry 128, 549–554.Google Scholar
Dally, P. & Gomez, J. (1979). Anorexia Nervosa. Heinemann: London.Google Scholar
Garfinkel, P. E., Moldofsky, H. & Garner, D. M. (1980). The heterogeneity of anorexia nervosa. Archives of General Psychiatry 37, 1036–1040.CrossRefGoogle ScholarPubMed
Gershon, E. S., Hamovit, J., Guroff, J. J, Dibble, E., Leckman, J. F., Sceery, W., Targum, S. D., Nurnberger, J. I. Jr, Goldin, L. R. & Bunnery, W. W. Jr, (1982). A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry 39, 1157–1167.Google Scholar
Gershon, E. S., Hamovit, J. R., Schreiber, J. L., Dibble, E. D., Kaye, W. H., Nurnberger, J. I. Jr, Andersen, A. & Ebert, M. H. (1983). Anorexia nervosa and major affective disorders associated in families: a preliminary report. In Childhood Psychopathology and Development (ed. Guze, S. B., Earls, F. J. & Barrett, J. E.), pp. 279–286. Raven Press: New York.Google Scholar
Garshon, E. S., Schreiber, J. L., Hamovit, J. R., Dibble, E. D., Kaye, W., Nurnberger, J. I. Jr, Andersen, A. E. & Ebert, M. H. (1984). Clinical findings in patients with anorexia nervosa and affective illness in their relatives. American Journal of Psychiatry 141, 1419–1422.Google Scholar
Gwirtsman, H. E., Roy-Byrne, P., Yager, J. & Gerner, R. H. (1983). Neuroendocrine abnormalities in bulimia. American Journal of Psychiatry 140, 559–563.Google ScholarPubMed
Halmi, K. A., Goldberg, S. C., Eckert, E., Casper, R. & Davis, J. M. (1977). Pretreatment evaluation in anorexia nervosa. In Anorexia Nervosa (ed. Vigersky, R. A.), pp. 43–54. Raven Press: New York.Google ScholarPubMed
Herzog, D. B. (1982). Bulimia in the adolescent. American Journal of Diseases of Childhood 136, 985–989.Google ScholarPubMed
Hudson, J. I. & Hudson, M. S. (1984). Endocrine dysfunction in anorexia nervosa and bulimia: comparison with abnormalities in other psychiatric disorders and disturbances due to metabolic factors. Psychiatric Developments 4, 237–272.Google Scholar
Hudson, J. I. & Pope, H. G. Jr, (1987). Depression and eating disorders. In Presentations of Depression (ed. Cameron, O. G.), pp. 33–66. John Wiley: New York.Google Scholar
Hudson, J. I., Pope, H. G. Jr, Jonas, J. M. & Yurgelun-Todd, D. (1983 a). Phenomenologic relationship of eating disorders to major affective disorder. Psychiatry Research 9, 345–354.Google Scholar
Hudson, J. I., Pope, H. G. Jr, Jonas, J. M. & Yurgelun-Todd, D. (1983 b). Family history study of anorexia nervosa and bulimia. British Journal of Psychiatry 142, 133–138; Erratum (1983), British Journal of Psychiatry 142, 428–429.CrossRefGoogle ScholarPubMed
Hudson, J. I., Pope, H. G. Jr, Yurgelun-Todd, D. & Jonas, J. M. (1984). Affective symptoms in bulimia: a controlled study.Presented at the American Psychiatric Association Annual Meeting,Los Angeles,May, 1984.Google Scholar
Hudson, J. I., Hudson, M. S., Pliner, L. F., Goldenberg, D. L. & Pope, H. G. Jr, (1985). Fibromyalgia and major affective disorder: a controlled phenomenology and family history study. American Journal of Psychiatry 142, 441–446.Google Scholar
Lee, N. F., Rush, A. J. & Mitchell, J. E. (1985). Depression and bulimia. Journal of Affective Disorders 9, 231–238.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Fleiss, J. L., Cataldo, M. & Rainer, J. (1975). Accuracy of the family history method in affective illness. Archives of General Psychiatry 32, 309–314.Google Scholar
Mindham, R. H. S., Bagshaw, A., James, S. A. & Swannell, A. J. (1981). Factors associated with the appearance of psychiatric symptoms in rheumatoid arthritis. Journal of Psychosomatic Research 25, 429–435.CrossRefGoogle ScholarPubMed
Mitchell, J. E., Hatsukami, D., Pyle, R. L. & Eckert, E. D. (1986). Bulimia with and without a family history of depressive illness. Comprehensive Psychiatry 27, 215–219.CrossRefGoogle ScholarPubMed
Musisi, S. & Garfinkel, P. E. (1985). Comparative dexamethasone suppression test measurements in bulimia, depression and normal controls. Canadian Journal of Psychiatry 30, 190–194.CrossRefGoogle ScholarPubMed
Pope, H. G. Jr, & Hudson, J. I. (1986). Antidepressant drug treatment of bulimia: current status. Journal of Clinical Psychiatry 47, 339–345.Google ScholarPubMed
Pyle, R. L., Mitchell, J. E. & Eckert, E. D. (1981). Bulimia: a report of 34 cases Journal of Clinical Psychiatry 42, 60–64.Google Scholar
Rivinus, T. M., Biederman, J., Herzog, D. B., Kemper, K., Harper, G. P., Harmatz, J. S. & Houseworth, S. (1984). Anorexia nervosa and affective disorders. a controlled family history study. American Journal of Psychiatry 141, 1414–1418.Google ScholarPubMed
Robins, L. N., Helzer, J. E., Croughan, J., Williams, J. W. & Spitzer, R. L. (1980). NIMH Diagnostic Interview Schedule (2nd edn). National Institute of Mental Health: Rockville, Md.Google Scholar
Robins, L. N., Helzer, J. E., Weissman, M. M., Orvaschel, H., Gruenberg, E., Burke, J. D. & Regier, D. A. (1984). Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry 41, 949–958.CrossRefGoogle ScholarPubMed
Slater, E. & Cowie, V. (1971). The Genetics of Mental Illness. Oxford University Press: London.Google Scholar
Society of Actuaries and Association of Life Insurance Medical Directors of America (1980). 1979 Build Study.Google Scholar
Stern, S. L., Dixon, K. N., Nemzer, E., Lake, M. D., Sansone, R. A., Smeltzer, D. J., Lantz, S. & Schrier, S. S. (1984). Affective disorder in the families of women with normal weight bulimia. American Journal of Psychiatry 141, 1224–1227.Google Scholar
Stern, S. L., Dixon, K. N., Jones, D., Lake, M., Nemzer, E. & Sansone, R. (1986). Substance use disorder in relatives of anorectic and normal weight bulimic women.Presented at the Second International Conference on Eating Disorders, April, 1986New York,April, 1986.Google Scholar
Strober, M. (1981). The significance of bulimia in juvenile anorexia nervosa: an exploration of possible etiologic factors. International Journal of Eating Disorders 1, 28–43.Google Scholar
Strober, M., Salkin, B., Burroughs, J. & Morrell, W. (1982). Validity of the bulimia-restrictor distinction in anorexia nervosa: parental personality characteristics and family psychiatric morbidity. Journal of Nervous and Mental Disease 170, 345–351.CrossRefGoogle ScholarPubMed
Strober, M., Morrell, W., Burroughs, J., Salkin, B. & Jacobs, C. (1985). A controlled family study of anorexia nervosa. Journal of Psychiatric Research 19, 239–246.CrossRefGoogle ScholarPubMed
Strober, M., Salkin, B., Burroughs, J., Morrell, W. & Sadjak, J. (1986). A family study of anorexia nervosa and depression.Presented at the Second International Conference on Eating Disorders,New York,April, 1986.Google Scholar
Theander, S. (1970). Anorexia nervosa. A psychiatric investigation of 94 female patients. Acta Psychiatrica Scandanavica Suppl. 214.Google Scholar
Thompson, W. D., Orvaschel, H., Prusoff, B. A. & Kidd, K. K. (1982). An evaluation of the family history for ascertaining psychiatric disorders. Archives of General Psychiatry 39, 53–58.Google Scholar
Viesselman, J. O. & Roig, M. (1985). Depression and suicidality in eating disorders. Journal of Clinical Psychiatry 46, 118–124.Google ScholarPubMed
Walsh, B. T., Roose, S. P., Glassman, A. H., Gladis, M. & Sadik, C. (1985). Bulimia and depression. Psychosomatic Medicine 47, 123–131.Google Scholar
Winokur, A., March, S. & Mendels, J. (1980). Primary affective disorder in relatives of patients with anorexia nervosa. American Journal of Psychiatry 137, 695–698.Google ScholarPubMed