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Classification of depression and response to amitriptyline therapy

Published online by Cambridge University Press:  09 July 2009

V. A. Rama Rao  and
Alec Coppen
V. A. Rama Rao*
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Alec Coppen
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
*
1Address for correspondence: Dr V. A, Rama Rao, MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey, KTI9 8PB.
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Synopsis

Fifty-four patients suffering from primary depressive illness were rated on the Newcastle diagnostic scale while taking part in a pharmacokinetic study of amitriptyline therapy, and their clinical response was assessed by the Hamilton Rating Scale for depression. Patients with a Newcastle score of 4−8 showed the best response to amitriptyline. Patients with low Newcastle scores, representing the non-endogenous or neurotic group, responded poorly. Patients with high scores on the Newcastle scale, representing those with marked endogenous features, also responded poorly.

Type
Research Article
Information
Psychological Medicine , Volume 9 , Issue 2 , May 1979 , pp. 321 - 325
Copyright
Copyright © Cambridge University Press 1979

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References

Bielski, R. J. & Friedel, R. O. (1976). Prediction of tricyclic antidepressant response: a critical review. Archives of General Psychiatry 33, 1479–1489.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, R. F. (1965). The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry 111, 659–674.CrossRefGoogle Scholar
Coppen, A., Ghose, K., Montgomery, S., Rama Rao, V. A., Bailey, J., Christiansen, J., Mikkleson, P. L., van Praag, H. M., van de Poel, F., Minsker, E. J., Kozulja, V. G., Mattusek, N., Kungkunz, G. & Jørgensen, A. (1978). Amitriptyline plasma-concentration and clinical effect. A World Health Organization collaborative study. Lancet i, 63–66.CrossRefGoogle Scholar
Glassman, A. J., Kantor, S. J. & Shostak, M. (1975). Depression, delusions and drug response. American Journal of Psychiatry 132, 716–719.Google ScholarPubMed
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56–62.CrossRefGoogle ScholarPubMed
Medical Research Council (1965). Clinical trial of the treatment of depressive illness. Report to the Medical Research Council by its Clinical Psychiatry Committee. British Medical Journal i, 881–886.Google Scholar
Reisby, N., Gram, L. F., Bech, P., Nagy, A., Petersen, G. O., Ortmann, J., Ibsen, I., Dencker, S., Jacobsen, O., Krautwald, O., Søndergaard, I. & Christiansen, J. (1977). Imipramine: clinical effects and pharmacokinetic variability. Psychopharmacology 54, 263–272.CrossRefGoogle ScholarPubMed
Robinson, D. S., Nies, A., Ravaris, C. L., Ives, J. O. & Lamborn, K. R. (1974). Treatment response to MAO inhibitors relation to depressive typology and blood platelet MAO inhibition. In Classification and Prediction of Outcome of Depression, Symposia Medica Hoechst 8 (ed. Angst, J.). Schattauer Verlag: Stuttgart/New York.Google Scholar
Wood, K., Harwood, J., Swade, C. & Coppen, A. (1978). Decreased tryptophan excretion by depressive patients. Clinica Chimica Acta 88, 57–61.CrossRefGoogle ScholarPubMed